Motif ID: Hmx2

Z-value: 0.438


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_131548773-0.381.8e-01Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 120 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_8660059 1.183 ENSMUST00000047753.4
 Abcb1a
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
chr12_-_98901478 1.014 ENSMUST00000065716.6
 Eml5
echinoderm microtubule associated protein like 5
chr4_+_90218820 0.874 ENSMUST00000107129.1
 Zfp352
zinc finger protein 352
chr6_-_137169678 0.753 ENSMUST00000119610.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr4_+_145510759 0.612 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr8_-_8690493 0.605 ENSMUST00000048545.8
 Arglu1
arginine and glutamate rich 1
chr6_-_137169710 0.602 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chrM_+_7759 0.588 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr18_+_50051702 0.571 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr4_-_128962420 0.560 ENSMUST00000119354.1
ENSMUST00000106068.1
ENSMUST00000030581.3
 Adc


arginine decarboxylase


chr5_-_28210022 0.559 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr2_+_35132194 0.496 ENSMUST00000113034.1
ENSMUST00000113037.3
ENSMUST00000113033.2
 Cep110


centrosomal protein 110


chr3_+_109573907 0.491 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr10_+_128908907 0.476 ENSMUST00000105229.1
 Cd63
CD63 antigen
chr15_-_42676967 0.468 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr1_-_162866502 0.438 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr5_-_20951769 0.431 ENSMUST00000036489.5
 Rsbn1l
round spermatid basic protein 1-like
chr1_+_173420567 0.420 ENSMUST00000173023.1
 Aim2
absent in melanoma 2
chrX_+_112615301 0.394 ENSMUST00000122805.1
 Zfp711
zinc finger protein 711
chr19_-_58454435 0.383 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.2 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.3 0.8 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.6 GO:0032611 interleukin-1 beta production(GO:0032611)
0.1 0.5 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.0 0.5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1 0.4 GO:0070269 pyroptosis(GO:0070269)
0.1 0.4 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.4 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.3 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.3 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0 0.3 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 0.2 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.1 0.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.2 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.4 GO:0061702 inflammasome complex(GO:0061702)
0.1 0.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.1 GO:0070891 peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)