Motif ID: Hmx2

Z-value: 0.438


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_131548773-0.381.8e-01Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_8660059 1.183 ENSMUST00000047753.4
 Abcb1a
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
chr12_-_98901478 1.014 ENSMUST00000065716.6
 Eml5
echinoderm microtubule associated protein like 5
chr4_+_90218820 0.874 ENSMUST00000107129.1
 Zfp352
zinc finger protein 352
chr6_-_137169678 0.753 ENSMUST00000119610.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr4_+_145510759 0.612 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr8_-_8690493 0.605 ENSMUST00000048545.8
 Arglu1
arginine and glutamate rich 1
chr6_-_137169710 0.602 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chrM_+_7759 0.588 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr18_+_50051702 0.571 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr4_-_128962420 0.560 ENSMUST00000119354.1
ENSMUST00000106068.1
ENSMUST00000030581.3
 Adc


arginine decarboxylase


chr5_-_28210022 0.559 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr2_+_35132194 0.496 ENSMUST00000113034.1
ENSMUST00000113037.3
ENSMUST00000113033.2
 Cep110


centrosomal protein 110


chr3_+_109573907 0.491 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr10_+_128908907 0.476 ENSMUST00000105229.1
 Cd63
CD63 antigen
chr15_-_42676967 0.468 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr1_-_162866502 0.438 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr5_-_20951769 0.431 ENSMUST00000036489.5
 Rsbn1l
round spermatid basic protein 1-like
chr1_+_173420567 0.420 ENSMUST00000173023.1
 Aim2
absent in melanoma 2
chrX_+_112615301 0.394 ENSMUST00000122805.1
 Zfp711
zinc finger protein 711
chr19_-_58454435 0.383 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr5_-_131307848 0.382 ENSMUST00000086023.5
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr1_+_46066738 0.374 ENSMUST00000069293.7
 Dnah7b
dynein, axonemal, heavy chain 7B
chr3_+_106721672 0.369 ENSMUST00000098750.2
ENSMUST00000130105.1
 Lrif1

ligand dependent nuclear receptor interacting factor 1

chr11_-_3931960 0.368 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
 Tcn2




transcobalamin 2




chr14_+_73237891 0.356 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr8_+_34054622 0.353 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr12_-_90969768 0.349 ENSMUST00000181184.1
 4930544I03Rik
RIKEN cDNA 4930544I03 gene
chr3_-_88410295 0.344 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr4_-_62470868 0.331 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr9_-_122310921 0.322 ENSMUST00000180685.1
 Gm26797
predicted gene, 26797
chr1_-_57970067 0.317 ENSMUST00000164963.1
 Kctd18
potassium channel tetramerisation domain containing 18
chr4_+_94739276 0.317 ENSMUST00000073939.6
ENSMUST00000102798.1
 Tek

endothelial-specific receptor tyrosine kinase

chr7_+_45062429 0.311 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
 Nosip



nitric oxide synthase interacting protein



chr6_+_29694204 0.306 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr4_-_26346882 0.305 ENSMUST00000041374.7
ENSMUST00000153813.1
 Manea

mannosidase, endo-alpha

chr10_-_22149270 0.288 ENSMUST00000179054.1
ENSMUST00000069372.6
 E030030I06Rik

RIKEN cDNA E030030I06 gene

chr10_-_127311740 0.287 ENSMUST00000037290.5
ENSMUST00000171564.1
 Mars

methionine-tRNA synthetase

chr3_-_116712644 0.286 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr15_+_85510812 0.284 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr11_-_96977660 0.283 ENSMUST00000107626.1
ENSMUST00000107624.1
 Sp2

Sp2 transcription factor

chr5_-_131308076 0.269 ENSMUST00000160609.1
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr9_-_37552904 0.269 ENSMUST00000065668.5
 Nrgn
neurogranin
chr18_-_34579072 0.262 ENSMUST00000079287.5
 Nme5
NME/NM23 family member 5
chr4_+_145585166 0.242 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr2_+_55411790 0.228 ENSMUST00000155997.1
ENSMUST00000128307.1
 Gm14033

predicted gene 14033

chr11_-_100822525 0.215 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr10_+_63061582 0.200 ENSMUST00000020266.8
ENSMUST00000178684.1
 Pbld1

phenazine biosynthesis-like protein domain containing 1

chr8_-_105568298 0.199 ENSMUST00000005849.5
 Agrp
agouti related protein
chr8_-_123318553 0.193 ENSMUST00000118395.1
ENSMUST00000035495.8
 Fanca

Fanconi anemia, complementation group A

chr5_+_3343893 0.186 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr18_-_88894322 0.183 ENSMUST00000070116.5
ENSMUST00000125362.1
 Socs6

suppressor of cytokine signaling 6

chr9_-_53667429 0.182 ENSMUST00000166367.1
ENSMUST00000034529.7
 Cul5

cullin 5

chr2_+_83644435 0.179 ENSMUST00000081591.6
 Zc3h15
zinc finger CCCH-type containing 15
chr7_-_43505926 0.178 ENSMUST00000013497.1
ENSMUST00000163619.1
 4931406B18Rik

RIKEN cDNA 4931406B18 gene

chr16_-_14291355 0.177 ENSMUST00000090287.3
 Myh11
myosin, heavy polypeptide 11, smooth muscle
chr6_+_40471352 0.176 ENSMUST00000114779.2
ENSMUST00000031971.6
ENSMUST00000121360.1
ENSMUST00000117411.1
ENSMUST00000117830.1
 Ssbp1




single-stranded DNA binding protein 1




chr3_+_19957037 0.175 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
 Cp


ceruloplasmin


chr9_+_92457369 0.175 ENSMUST00000034941.7
 Plscr4
phospholipid scramblase 4
chr17_+_46428930 0.174 ENSMUST00000024764.5
ENSMUST00000165993.1
 Crip3

cysteine-rich protein 3

chr12_+_117843873 0.169 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr1_-_57970104 0.157 ENSMUST00000114410.3
 Kctd18
potassium channel tetramerisation domain containing 18
chr16_+_36934976 0.150 ENSMUST00000023531.8
 Hcls1
hematopoietic cell specific Lyn substrate 1
chr13_-_107022027 0.149 ENSMUST00000117539.1
ENSMUST00000122233.1
ENSMUST00000022204.9
ENSMUST00000159772.1
 Kif2a



kinesin family member 2A



chr4_+_147492417 0.149 ENSMUST00000105721.2
 Gm13152
predicted gene 13152
chr12_-_101913116 0.149 ENSMUST00000177536.1
ENSMUST00000176728.1
ENSMUST00000021605.7
 Trip11


thyroid hormone receptor interactor 11


chrX_-_75578188 0.148 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chrX_-_134111852 0.147 ENSMUST00000033610.6
 Nox1
NADPH oxidase 1
chr3_+_84952146 0.144 ENSMUST00000029727.7
 Fbxw7
F-box and WD-40 domain protein 7
chr2_-_33087169 0.143 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr4_-_56947411 0.140 ENSMUST00000107609.3
ENSMUST00000068792.6
 Tmem245

transmembrane protein 245

chr10_-_37138863 0.125 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr1_-_75142360 0.121 ENSMUST00000041213.5
 Cnppd1
cyclin Pas1/PHO80 domain containing 1
chr15_+_102407144 0.120 ENSMUST00000169619.1
 Sp1
trans-acting transcription factor 1
chr18_+_37819543 0.107 ENSMUST00000055935.5
 Pcdhga9
protocadherin gamma subfamily A, 9
chr3_+_66985947 0.104 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr17_-_53539411 0.099 ENSMUST00000056198.3
 Pp2d1
protein phosphatase 2C-like domain containing 1
chr5_+_8893677 0.098 ENSMUST00000003717.8
 Abcb4
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr2_-_164071089 0.095 ENSMUST00000018466.3
 Tomm34
translocase of outer mitochondrial membrane 34
chr8_+_90828820 0.093 ENSMUST00000109614.2
ENSMUST00000048665.6
 Chd9

chromodomain helicase DNA binding protein 9

chrX_-_164027965 0.092 ENSMUST00000033739.4
 Car5b
carbonic anhydrase 5b, mitochondrial
chr3_-_87748619 0.090 ENSMUST00000023846.4
 Lrrc71
leucine rich repeat containing 71
chr13_+_83732438 0.086 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr6_-_113501818 0.085 ENSMUST00000101059.1
 Prrt3
proline-rich transmembrane protein 3
chr4_-_94603239 0.083 ENSMUST00000107107.2
 Plaa
phospholipase A2, activating protein
chr10_+_121365078 0.080 ENSMUST00000040344.6
 Gns
glucosamine (N-acetyl)-6-sulfatase
chr5_-_140830430 0.080 ENSMUST00000000153.4
 Gna12
guanine nucleotide binding protein, alpha 12
chr6_-_108185552 0.077 ENSMUST00000167338.1
ENSMUST00000172188.1
ENSMUST00000032191.9
 Sumf1


sulfatase modifying factor 1


chr17_+_48346465 0.074 ENSMUST00000113237.3
 Trem2
triggering receptor expressed on myeloid cells 2
chr10_+_69925766 0.073 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chr9_-_54501496 0.071 ENSMUST00000118600.1
ENSMUST00000118163.1
 Dmxl2

Dmx-like 2

chr1_+_91298354 0.068 ENSMUST00000142488.1
ENSMUST00000124832.1
ENSMUST00000147523.1
 Scly


selenocysteine lyase


chr5_-_28210168 0.066 ENSMUST00000117098.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr13_-_71963713 0.058 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr4_+_122836236 0.058 ENSMUST00000030412.4
ENSMUST00000121870.1
ENSMUST00000097902.4
 Ppt1


palmitoyl-protein thioesterase 1


chr7_+_43690418 0.057 ENSMUST00000056329.6
 Klk14
kallikrein related-peptidase 14
chr11_-_115933464 0.056 ENSMUST00000021097.3
 Recql5
RecQ protein-like 5
chr12_+_102128718 0.051 ENSMUST00000159329.1
 Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr2_-_127444524 0.050 ENSMUST00000028848.3
 Fahd2a
fumarylacetoacetate hydrolase domain containing 2A
chr10_-_81001338 0.049 ENSMUST00000099462.1
ENSMUST00000118233.1
 Gng7

guanine nucleotide binding protein (G protein), gamma 7

chr2_-_33086366 0.049 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr1_-_172632931 0.046 ENSMUST00000027826.5
 Dusp23
dual specificity phosphatase 23
chr5_+_146948640 0.040 ENSMUST00000146511.1
ENSMUST00000132102.1
 Gtf3a

general transcription factor III A

chr9_+_86485407 0.038 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chr2_+_167421706 0.037 ENSMUST00000047815.6
ENSMUST00000109218.1
ENSMUST00000073873.3
 Slc9a8


solute carrier family 9 (sodium/hydrogen exchanger), member 8


chr2_-_164071124 0.035 ENSMUST00000109384.3
 Tomm34
translocase of outer mitochondrial membrane 34
chr19_-_41933276 0.035 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr19_-_46969474 0.035 ENSMUST00000086961.7
 Nt5c2
5'-nucleotidase, cytosolic II
chr18_-_43477764 0.028 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr5_+_23850590 0.023 ENSMUST00000181574.1
 2700038G22Rik
RIKEN cDNA 2700038G22 gene
chr13_-_92794809 0.022 ENSMUST00000022213.7
 Thbs4
thrombospondin 4
chr11_-_78080360 0.022 ENSMUST00000021183.3
 Eral1
Era (G-protein)-like 1 (E. coli)
chrX_+_150594420 0.020 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chrX_-_56598069 0.019 ENSMUST00000059899.2
 Mmgt1
membrane magnesium transporter 1
chr8_-_22694061 0.016 ENSMUST00000131767.1
 Ikbkb
inhibitor of kappaB kinase beta
chr9_-_113708209 0.015 ENSMUST00000111861.3
ENSMUST00000035086.6
 Pdcd6ip

programmed cell death 6 interacting protein

chr3_+_10088173 0.014 ENSMUST00000061419.7
 Gm9833
predicted gene 9833
chr2_-_24049389 0.014 ENSMUST00000051416.5
 Hnmt
histamine N-methyltransferase
chr10_+_123264076 0.013 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr4_+_124880899 0.006 ENSMUST00000059343.6
 Epha10
Eph receptor A10
chr7_-_37772868 0.003 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.3 0.8 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.4 GO:0070269 pyroptosis(GO:0070269)
0.1 0.4 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.5 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.1 0.2 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.1 0.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.2 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.4 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.3 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.1 GO:0045472 response to ether(GO:0045472)
0.0 0.2 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.3 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0 0.3 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.0 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.0 0.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.1 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413)
0.0 0.6 GO:0032611 interleukin-1 beta production(GO:0032611)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.5 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 0.4 GO:0061702 inflammasome complex(GO:0061702)
0.1 0.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0070891 peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891)
0.0 0.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)