Motif ID: Foxo6

Z-value: 0.646


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_1202873490.641.4e-02Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_88724667 1.279 ENSMUST00000163271.1
 Mgll
monoglyceride lipase
chr1_-_184883218 1.013 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr11_+_29463735 0.771 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr4_+_102570065 0.727 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr8_+_25911670 0.721 ENSMUST00000120653.1
ENSMUST00000126226.1
 Kcnu1

potassium channel, subfamily U, member 1

chr11_-_12027958 0.645 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr10_-_93310963 0.609 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr6_-_23248264 0.550 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_163761323 0.515 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr8_+_46986913 0.436 ENSMUST00000039840.7
ENSMUST00000119686.1
 Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr19_-_45742873 0.407 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr7_+_62476306 0.392 ENSMUST00000097132.3
 Atp5l-ps1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g, pseudogene 1
chr11_+_87853207 0.370 ENSMUST00000038196.6
 Mks1
Meckel syndrome, type 1
chr3_+_103968110 0.363 ENSMUST00000117150.1
ENSMUST00000063717.7
ENSMUST00000055425.8
ENSMUST00000123611.1
ENSMUST00000090685.4
 Phtf1




putative homeodomain transcription factor 1




chr10_-_93311073 0.351 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chrX_+_106920618 0.314 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr12_-_98577940 0.310 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr1_+_74391479 0.300 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr9_-_22071345 0.292 ENSMUST00000179605.1
ENSMUST00000043922.6
 Zfp653

zinc finger protein 653

chr1_+_171270321 0.280 ENSMUST00000064272.3
ENSMUST00000141999.1
ENSMUST00000111313.3
 B4galt3


UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3


chr7_+_19368498 0.264 ENSMUST00000132655.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr17_-_57839233 0.263 ENSMUST00000095218.3
 Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chr5_-_65391380 0.259 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr3_-_51408925 0.257 ENSMUST00000038108.6
 Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr10_+_79879614 0.255 ENSMUST00000006679.8
 Prtn3
proteinase 3
chr18_-_60648290 0.251 ENSMUST00000143275.2
 Synpo
synaptopodin
chr19_+_8892987 0.244 ENSMUST00000096249.5
 Ints5
integrator complex subunit 5
chr7_+_28440927 0.244 ENSMUST00000078845.6
 Gmfg
glia maturation factor, gamma
chr8_+_36489191 0.233 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr5_-_65391408 0.232 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chrX_-_8193387 0.221 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr1_-_180245927 0.219 ENSMUST00000010753.7
 Psen2
presenilin 2
chr12_-_84617326 0.211 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr15_-_75111684 0.202 ENSMUST00000100542.3
 Ly6c2
lymphocyte antigen 6 complex, locus C2
chr16_+_10812915 0.202 ENSMUST00000115822.1
 Gm11172
predicted gene 11172
chr4_-_139131058 0.195 ENSMUST00000143971.1
 Minos1
mitochondrial inner membrane organizing system 1
chr4_+_62286441 0.183 ENSMUST00000084530.2
 Slc31a2
solute carrier family 31, member 2
chr1_-_180245757 0.176 ENSMUST00000111104.1
 Psen2
presenilin 2
chr5_+_110330697 0.167 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr5_+_7179299 0.163 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr15_-_81843699 0.161 ENSMUST00000092020.2
 Gm8444
predicted gene 8444
chr9_+_6168638 0.156 ENSMUST00000058692.7
 Pdgfd
platelet-derived growth factor, D polypeptide
chr17_-_24696147 0.151 ENSMUST00000046839.8
 Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr5_+_115605642 0.146 ENSMUST00000094427.3
 Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr10_+_39732364 0.145 ENSMUST00000164763.1
 Rev3l
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr16_+_44943737 0.141 ENSMUST00000114622.3
ENSMUST00000166731.1
 Cd200r3

CD200 receptor 3

chr2_-_30194112 0.135 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr14_+_34170640 0.134 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr10_+_39732099 0.128 ENSMUST00000019986.6
 Rev3l
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr2_-_93046053 0.123 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr7_-_123369870 0.121 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
 Arhgap17


Rho GTPase activating protein 17


chr5_+_115279666 0.113 ENSMUST00000040421.4
 Coq5
coenzyme Q5 homolog, methyltransferase (yeast)
chr11_+_85832551 0.106 ENSMUST00000000095.6
 Tbx2
T-box 2
chr2_-_155357392 0.105 ENSMUST00000165234.1
ENSMUST00000077626.6
 Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr5_-_99037035 0.104 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr3_-_34351685 0.100 ENSMUST00000174114.1
 Gm20514
predicted gene 20514
chrX_+_134585644 0.099 ENSMUST00000113211.1
 Rpl36a
ribosomal protein L36A
chr2_+_120977017 0.099 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chr13_-_71963713 0.098 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr7_+_28808795 0.095 ENSMUST00000172529.1
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr4_-_149099802 0.094 ENSMUST00000103217.4
 Pex14
peroxisomal biogenesis factor 14
chr3_-_106167564 0.093 ENSMUST00000063062.8
 Chi3l3
chitinase 3-like 3
chr12_-_102423741 0.093 ENSMUST00000110020.1
 Lgmn
legumain
chr1_-_38664947 0.077 ENSMUST00000039827.7
ENSMUST00000027250.7
 Aff3

AF4/FMR2 family, member 3

chr8_+_83566671 0.076 ENSMUST00000036996.5
 Ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr11_+_54314896 0.073 ENSMUST00000072178.4
ENSMUST00000101211.2
ENSMUST00000101213.2
 Acsl6


acyl-CoA synthetase long-chain family member 6


chr4_+_134510999 0.070 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr1_-_160077918 0.069 ENSMUST00000028061.3
 4930562F07Rik
RIKEN cDNA 4930562F07 gene
chr7_+_140881898 0.063 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr14_-_47418407 0.062 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr11_+_69095217 0.060 ENSMUST00000101004.2
 Per1
period circadian clock 1
chr4_-_46196298 0.055 ENSMUST00000142380.1
ENSMUST00000058232.4
ENSMUST00000030013.5
 Xpa


xeroderma pigmentosum, complementation group A


chr2_+_91650169 0.052 ENSMUST00000090614.4
 Arhgap1
Rho GTPase activating protein 1
chr5_-_117389029 0.050 ENSMUST00000111953.1
ENSMUST00000086461.6
 Rfc5

replication factor C (activator 1) 5

chr15_+_100154379 0.049 ENSMUST00000023768.6
ENSMUST00000108971.2
 Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr7_+_64287665 0.047 ENSMUST00000032736.4
 Mtmr10
myotubularin related protein 10
chr1_-_162898665 0.040 ENSMUST00000111510.1
ENSMUST00000045902.6
 Fmo2

flavin containing monooxygenase 2

chr3_-_49757257 0.035 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr14_+_32166104 0.033 ENSMUST00000164341.1
 Ncoa4
nuclear receptor coactivator 4
chr12_-_113260217 0.026 ENSMUST00000178282.1
 Igha
immunoglobulin heavy constant alpha
chr11_-_89639631 0.026 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr3_-_127780461 0.024 ENSMUST00000029662.5
ENSMUST00000161239.1
 Alpk1

alpha-kinase 1

chr14_-_50924626 0.020 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
 Osgep


O-sialoglycoprotein endopeptidase


chr17_+_25471564 0.019 ENSMUST00000025002.1
 Tekt4
tektin 4
chr17_-_31277327 0.017 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr5_-_52190484 0.012 ENSMUST00000031061.7
 Dhx15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr4_+_48663502 0.009 ENSMUST00000030033.4
 Murc
muscle-related coiled-coil protein
chr19_-_46969474 0.004 ENSMUST00000086961.7
 Nt5c2
5'-nucleotidase, cytosolic II
chr18_-_31911903 0.003 ENSMUST00000054984.6
 Sft2d3
SFT2 domain containing 3
chr9_-_78587968 0.003 ENSMUST00000117645.1
ENSMUST00000119213.1
ENSMUST00000052441.5
 Slc17a5


solute carrier family 17 (anion/sugar transporter), member 5


chr7_-_14562171 0.003 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.4 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.1 0.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.4 GO:0019695 choline metabolic process(GO:0019695)
0.1 0.6 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.4 GO:1903887 motile primary cilium assembly(GO:1903887)
0.1 0.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.2 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.4 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.0 0.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.8 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.2 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.3 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.2 GO:0097421 liver regeneration(GO:0097421)
0.0 0.3 GO:0030574 collagen catabolic process(GO:0030574) negative regulation of phagocytosis(GO:0050765)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0 0.1 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)
0.0 0.0 GO:0072592 oxygen metabolic process(GO:0072592)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0043196 varicosity(GO:0043196)
0.1 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 1.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 1.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.3 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.1 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.8 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.7 GO:0030552 cAMP binding(GO:0030552)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)