Motif ID: Zscan4c

Z-value: 0.679


Transcription factors associated with Zscan4c:

Gene SymbolEntrez IDGene Name
Zscan4c ENSMUSG00000054272.5 Zscan4c



Activity profile for motif Zscan4c.

activity profile for motif Zscan4c


Sorted Z-values histogram for motif Zscan4c

Sorted Z-values for motif Zscan4c



Network of associatons between targets according to the STRING database.



First level regulatory network of Zscan4c

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_118283719 4.131 ENSMUST00000117160.1
Cdh13
cadherin 13
chr2_+_68861564 3.434 ENSMUST00000176018.1
Cers6
ceramide synthase 6
chr7_-_119184374 2.257 ENSMUST00000084650.4
Gpr139
G protein-coupled receptor 139
chr5_-_128953303 2.212 ENSMUST00000111346.1
Rimbp2
RIMS binding protein 2
chr13_+_58807884 1.996 ENSMUST00000079828.5
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr8_-_48555846 1.927 ENSMUST00000110345.1
ENSMUST00000110343.1
Tenm3

teneurin transmembrane protein 3

chr9_+_26733728 1.892 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr2_+_68861433 1.882 ENSMUST00000028426.2
Cers6
ceramide synthase 6
chr14_-_60177482 1.487 ENSMUST00000140924.1
Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr9_+_26733845 1.459 ENSMUST00000115269.2
B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr5_-_44799643 1.399 ENSMUST00000070748.5
Ldb2
LIM domain binding 2
chr3_-_158562199 1.386 ENSMUST00000106044.1
Lrrc7
leucine rich repeat containing 7
chr9_-_50739365 1.318 ENSMUST00000117093.1
ENSMUST00000121634.1
Dixdc1

DIX domain containing 1

chr2_+_102659213 1.299 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr9_-_49798905 1.192 ENSMUST00000114476.2
Ncam1
neural cell adhesion molecule 1
chr15_-_85578070 1.081 ENSMUST00000109424.2
Wnt7b
wingless-related MMTV integration site 7B
chr13_-_56296551 1.008 ENSMUST00000021970.9
Cxcl14
chemokine (C-X-C motif) ligand 14
chr14_-_70627008 0.971 ENSMUST00000110984.2
Dmtn
dematin actin binding protein
chr6_-_55681257 0.965 ENSMUST00000044767.8
Neurod6
neurogenic differentiation 6
chr4_+_123183722 0.960 ENSMUST00000152194.1
Hpcal4
hippocalcin-like 4
chr9_+_89909775 0.931 ENSMUST00000034912.4
ENSMUST00000034909.4
Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr4_+_49059256 0.928 ENSMUST00000076670.2
E130309F12Rik
RIKEN cDNA E130309F12 gene
chr15_-_37458523 0.927 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr9_-_49798729 0.879 ENSMUST00000166811.2
Ncam1
neural cell adhesion molecule 1
chr2_-_166155624 0.784 ENSMUST00000109249.2
Sulf2
sulfatase 2
chr3_+_134236483 0.772 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4

chr15_-_78718113 0.730 ENSMUST00000088592.4
Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr7_+_46841475 0.691 ENSMUST00000147535.1
Ldha
lactate dehydrogenase A
chr4_+_123183456 0.681 ENSMUST00000126995.1
Hpcal4
hippocalcin-like 4
chr5_+_27261916 0.651 ENSMUST00000101471.3
Dpp6
dipeptidylpeptidase 6
chr2_-_166155272 0.560 ENSMUST00000088086.3
Sulf2
sulfatase 2
chr4_-_87806276 0.522 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr19_+_8664005 0.508 ENSMUST00000035444.3
ENSMUST00000163785.1
Chrm1

cholinergic receptor, muscarinic 1, CNS

chr2_-_91182848 0.477 ENSMUST00000111370.2
ENSMUST00000111376.1
ENSMUST00000099723.2
Madd


MAP-kinase activating death domain


chr13_+_42052015 0.465 ENSMUST00000060148.5
Hivep1
human immunodeficiency virus type I enhancer binding protein 1
chr4_-_87806296 0.448 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr7_-_98361275 0.435 ENSMUST00000094161.4
ENSMUST00000164726.1
ENSMUST00000167405.1
Tsku


tsukushi


chr2_+_19909769 0.416 ENSMUST00000114610.1
Etl4
enhancer trap locus 4
chr7_-_98178254 0.410 ENSMUST00000040971.7
Capn5
calpain 5
chr19_-_38819156 0.394 ENSMUST00000025963.7
Noc3l
nucleolar complex associated 3 homolog (S. cerevisiae)
chr6_+_100833606 0.379 ENSMUST00000063854.4
Ppp4r2
protein phosphatase 4, regulatory subunit 2
chr15_+_44619551 0.367 ENSMUST00000022964.7
Ebag9
estrogen receptor-binding fragment-associated gene 9
chr8_+_117257019 0.326 ENSMUST00000166750.1
Cmip
c-Maf inducing protein
chr2_+_106695594 0.304 ENSMUST00000016530.7
Mpped2
metallophosphoesterase domain containing 2
chr16_-_78576649 0.276 ENSMUST00000114220.1
ENSMUST00000114219.1
ENSMUST00000114218.1
D16Ertd472e


DNA segment, Chr 16, ERATO Doi 472, expressed


chr18_-_23041641 0.221 ENSMUST00000097651.3
Nol4
nucleolar protein 4
chr19_-_21472552 0.207 ENSMUST00000087600.3
Gda
guanine deaminase
chrX_-_64276937 0.200 ENSMUST00000114679.1
ENSMUST00000069926.7
Slitrk4

SLIT and NTRK-like family, member 4

chr8_+_62951361 0.193 ENSMUST00000119068.1
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr12_-_69892989 0.176 ENSMUST00000110567.1
ENSMUST00000171211.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr10_+_118860826 0.174 ENSMUST00000059966.4
4932442E05Rik
RIKEN cDNA 4932442E05 gene
chr7_+_144896523 0.165 ENSMUST00000033389.5
Fgf15
fibroblast growth factor 15
chr8_-_116732991 0.161 ENSMUST00000109102.2
Cdyl2
chromodomain protein, Y chromosome-like 2
chr10_-_78295394 0.146 ENSMUST00000105387.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr16_-_9994921 0.139 ENSMUST00000115835.1
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
chr2_+_57238297 0.133 ENSMUST00000112618.2
ENSMUST00000028167.2
Gpd2

glycerol phosphate dehydrogenase 2, mitochondrial

chr5_-_145201829 0.124 ENSMUST00000162220.1
ENSMUST00000031632.8
Zkscan14

zinc finger with KRAB and SCAN domains 14

chr3_+_125404072 0.120 ENSMUST00000173932.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr18_-_79109391 0.119 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1

SET binding protein 1

chr1_-_174921813 0.111 ENSMUST00000055294.3
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr19_+_47228804 0.098 ENSMUST00000111807.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr10_-_128645784 0.080 ENSMUST00000065334.3
Ikzf4
IKAROS family zinc finger 4
chr3_-_101836223 0.068 ENSMUST00000061831.4
Mab21l3
mab-21-like 3 (C. elegans)
chr7_-_47132698 0.059 ENSMUST00000033142.5
Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr10_+_74967164 0.054 ENSMUST00000037813.4
Gnaz
guanine nucleotide binding protein, alpha z subunit
chr15_-_79403248 0.036 ENSMUST00000074991.2
Tmem184b
transmembrane protein 184b
chr9_+_57940104 0.031 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr15_+_80173642 0.002 ENSMUST00000044970.6
Mgat3
mannoside acetylglucosaminyltransferase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.7 2.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.4 1.1 GO:0072070 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
0.3 1.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 1.0 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.3 2.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 1.0 GO:1901731 calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731)
0.2 1.9 GO:0097264 self proteolysis(GO:0097264)
0.2 1.5 GO:0061092 involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2 1.0 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.2 3.4 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.2 0.2 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.2 0.5 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.1 0.7 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 1.3 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 1.0 GO:0007379 segment specification(GO:0007379)
0.1 5.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 0.4 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.2 GO:0046098 guanine metabolic process(GO:0046098)
0.1 1.2 GO:0010669 epithelial structure maintenance(GO:0010669)
0.1 0.9 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.1 1.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 2.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.1 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 0.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.7 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of potassium ion transmembrane transport(GO:1901381)
0.0 0.4 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.1 GO:2001025 positive regulation of response to drug(GO:2001025)
0.0 0.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.1 GO:0048170 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of long-term neuronal synaptic plasticity(GO:0048170)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.4 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 2.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.4 GO:0043194 axon initial segment(GO:0043194)
0.0 5.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 0.5 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0055100 adiponectin binding(GO:0055100)
0.6 5.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.6 3.4 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.4 2.0 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.3 1.1 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.3 1.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 1.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 0.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.4 GO:0030362 protein phosphatase type 4 regulator activity(GO:0030362)
0.1 2.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.2 GO:0030274 LIM domain binding(GO:0030274)
0.1 2.1 GO:0030275 LRR domain binding(GO:0030275)
0.1 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0004368 glycerol-3-phosphate dehydrogenase activity(GO:0004368)
0.0 1.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.0 GO:0008009 chemokine activity(GO:0008009)
0.0 1.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.0 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0036122 BMP binding(GO:0036122)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)