Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.890

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.352.2e-01Click!
Vax1mm10_v2_chr19_-_59170978_591709780.352.2e-01Click!


Activity profile for motif Gsx2_Hoxd3_Vax1.

activity profile for motif Gsx2_Hoxd3_Vax1


Sorted Z-values histogram for motif Gsx2_Hoxd3_Vax1

Sorted Z-values for motif Gsx2_Hoxd3_Vax1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Top targets:


Showing 1 to 20 of 141 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 2.613 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr2_+_116067213 2.330 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr15_-_8710409 2.312 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_66219909 2.268 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr8_+_66386292 1.910 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr15_-_8710734 1.827 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_62766153 1.615 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_+_112760652 1.592 ENSMUST00000063888.3
 Pld4
phospholipase D family, member 4
chr4_-_14621669 1.581 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr2_-_116067391 1.543 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr12_+_38780284 1.509 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr3_-_59220150 1.451 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr8_+_94152607 1.449 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr4_-_14621494 1.398 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr18_+_56432116 1.386 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr5_+_66968559 1.374 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr2_+_109917639 1.359 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr18_+_12741324 1.212 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
 Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr12_+_38780817 1.139 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr5_+_66968416 1.078 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.6 GO:0019532 oxalate transport(GO:0019532)
1.0 4.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 3.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.8 2.3 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0 2.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 1.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.5 1.5 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.5 1.4 GO:0097212 lysosomal membrane organization(GO:0097212)
0.5 1.4 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 1.2 GO:0048240 sperm capacitation(GO:0048240)
0.2 1.1 GO:0030091 protein repair(GO:0030091)
0.0 1.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.3 0.9 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.0 0.9 GO:0019228 neuronal action potential(GO:0019228)
0.2 0.8 GO:0015819 lysine transport(GO:0015819)
0.1 0.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.7 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.2 0.6 GO:1904742 protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742)
0.2 0.6 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.2 0.5 GO:1902498 regulation of protein autoubiquitination(GO:1902498)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 4.1 GO:0043205 fibril(GO:0043205)
0.1 3.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.6 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.8 4.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 3.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 2.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 2.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 1.6 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.2 1.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 1.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.9 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.8 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.8 GO:0042287 MHC protein binding(GO:0042287)
0.1 0.7 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.5 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)