Motif ID: Lef1

Z-value: 1.438


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131112785_131112803-0.146.3e-01Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_22454290 2.877 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr14_-_98169542 2.651 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_+_96318014 2.276 ENSMUST00000135431.1
ENSMUST00000162807.2
 Lrrc4c

leucine rich repeat containing 4C

chr2_+_116067213 1.655 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr2_-_65567465 1.633 ENSMUST00000066432.5
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr15_-_58214882 1.589 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr2_-_65567505 1.549 ENSMUST00000100069.2
 Scn3a
sodium channel, voltage-gated, type III, alpha
chrX_+_109095359 1.501 ENSMUST00000033598.8
 Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr11_-_26210553 1.493 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr3_+_102010138 1.457 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr4_-_82705735 1.402 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr11_+_108920800 1.388 ENSMUST00000140821.1
 Axin2
axin2
chr4_-_91376490 1.369 ENSMUST00000107124.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr12_+_76072016 1.339 ENSMUST00000131480.1
 Syne2
spectrin repeat containing, nuclear envelope 2
chr16_-_91044473 1.279 ENSMUST00000118522.1
 Paxbp1
PAX3 and PAX7 binding protein 1
chr16_+_20097554 1.238 ENSMUST00000023509.3
 Klhl24
kelch-like 24
chr19_-_14598031 1.223 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr3_-_57575907 1.217 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr3_-_57575760 1.208 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr1_+_165788681 1.201 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 3.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.6 2.9 GO:0046684 response to pyrethroid(GO:0046684)
0.9 2.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.3 2.4 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 2.3 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 2.2 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 2.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.4 1.8 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.5 1.6 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.5 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 1.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.5 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.4 1.4 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 1.4 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.3 1.3 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 1.3 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.3 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.1 1.3 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.2 1.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 2.9 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 2.4 GO:0000922 spindle pole(GO:0000922)
0.6 2.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 2.0 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 1.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 1.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.2 GO:0043194 axon initial segment(GO:0043194)
0.0 1.2 GO:0016363 nuclear matrix(GO:0016363)
0.1 1.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.0 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 1.0 GO:0030014 CCR4-NOT complex(GO:0030014)
0.2 0.9 GO:0008623 CHRAC(GO:0008623)
0.1 0.9 GO:0044666 MLL3/4 complex(GO:0044666)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 3.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 3.2 GO:0031402 sodium ion binding(GO:0031402)
0.9 2.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 2.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.9 GO:0042805 actinin binding(GO:0042805)
0.1 1.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.5 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 1.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.3 GO:0004386 helicase activity(GO:0004386)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.1 GO:0001972 retinoic acid binding(GO:0001972)