Motif ID: Prox1

Z-value: 0.439


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.781.1e-03Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 70 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_68954351 1.247 ENSMUST00000030036.5
Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr9_+_118478182 0.791 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr7_-_127449109 0.629 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr2_+_136891501 0.591 ENSMUST00000141463.1
Slx4ip
SLX4 interacting protein
chr7_-_127448993 0.585 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr5_-_37824580 0.552 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr19_+_41911851 0.496 ENSMUST00000011896.6
Pgam1
phosphoglycerate mutase 1
chrX_-_43274786 0.488 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr1_-_169747634 0.449 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr4_+_42950369 0.407 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr12_-_83487708 0.395 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr7_+_24081888 0.389 ENSMUST00000068975.3
Zfp180
zinc finger protein 180
chr9_-_106247730 0.366 ENSMUST00000112524.2
ENSMUST00000074082.6
Alas1

aminolevulinic acid synthase 1

chr4_-_131821516 0.313 ENSMUST00000097860.2
Ptpru
protein tyrosine phosphatase, receptor type, U
chr18_-_20682963 0.312 ENSMUST00000165229.2
Gm10269
predicted gene 10269
chr14_-_55944536 0.308 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr6_+_58640536 0.299 ENSMUST00000145161.1
ENSMUST00000114294.1
Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr2_+_34406845 0.291 ENSMUST00000124443.1
ENSMUST00000113124.1
Mapkap1

mitogen-activated protein kinase associated protein 1

chr2_-_92459709 0.290 ENSMUST00000136718.1
ENSMUST00000067631.6
Slc35c1

solute carrier family 35, member C1

chr2_+_34406949 0.289 ENSMUST00000040459.4
Mapkap1
mitogen-activated protein kinase associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0042711 maternal behavior(GO:0042711)
0.0 1.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.3 0.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.0 0.8 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.2 0.6 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.2 0.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.4 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 0.3 GO:0046618 drug export(GO:0046618)
0.1 0.3 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.2 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.2 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.0 0.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.2 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0010796 regulation of multivesicular body size(GO:0010796)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.4 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:1990023 mitotic spindle midzone(GO:1990023)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0016749 N-succinyltransferase activity(GO:0016749)
0.1 0.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.2 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0 0.2 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)