Motif ID: Prox1

Z-value: 0.439


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.781.1e-03Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_68954351 1.247 ENSMUST00000030036.5
Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr9_+_118478182 0.791 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr7_-_127449109 0.629 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr2_+_136891501 0.591 ENSMUST00000141463.1
Slx4ip
SLX4 interacting protein
chr7_-_127448993 0.585 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr5_-_37824580 0.552 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr19_+_41911851 0.496 ENSMUST00000011896.6
Pgam1
phosphoglycerate mutase 1
chrX_-_43274786 0.488 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr1_-_169747634 0.449 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr4_+_42950369 0.407 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr12_-_83487708 0.395 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr7_+_24081888 0.389 ENSMUST00000068975.3
Zfp180
zinc finger protein 180
chr9_-_106247730 0.366 ENSMUST00000112524.2
ENSMUST00000074082.6
Alas1

aminolevulinic acid synthase 1

chr4_-_131821516 0.313 ENSMUST00000097860.2
Ptpru
protein tyrosine phosphatase, receptor type, U
chr18_-_20682963 0.312 ENSMUST00000165229.2
Gm10269
predicted gene 10269
chr14_-_55944536 0.308 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr6_+_58640536 0.299 ENSMUST00000145161.1
ENSMUST00000114294.1
Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr2_+_34406845 0.291 ENSMUST00000124443.1
ENSMUST00000113124.1
Mapkap1

mitogen-activated protein kinase associated protein 1

chr2_-_92459709 0.290 ENSMUST00000136718.1
ENSMUST00000067631.6
Slc35c1

solute carrier family 35, member C1

chr2_+_34406949 0.289 ENSMUST00000040459.4
Mapkap1
mitogen-activated protein kinase associated protein 1
chr4_-_36951223 0.278 ENSMUST00000108122.1
Lingo2
leucine rich repeat and Ig domain containing 2
chr5_-_138187177 0.266 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr17_+_27839974 0.266 ENSMUST00000071006.7
Snrpc
U1 small nuclear ribonucleoprotein C
chr19_+_46056539 0.253 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr2_+_34406882 0.243 ENSMUST00000113123.1
Mapkap1
mitogen-activated protein kinase associated protein 1
chr6_-_131388417 0.239 ENSMUST00000032309.6
ENSMUST00000087865.2
Ybx3

Y box protein 3

chr6_+_29361410 0.233 ENSMUST00000156163.1
Calu
calumenin
chr17_-_70924958 0.231 ENSMUST00000180468.1
Gm26510
predicted gene, 26510
chr14_-_96519067 0.209 ENSMUST00000022666.7
Klhl1
kelch-like 1
chr2_-_136891363 0.198 ENSMUST00000028730.6
ENSMUST00000110089.2
Mkks

McKusick-Kaufman syndrome

chr17_+_29319183 0.182 ENSMUST00000114699.1
ENSMUST00000155348.1
Pi16

peptidase inhibitor 16

chr17_+_47630690 0.173 ENSMUST00000024779.8
Usp49
ubiquitin specific peptidase 49
chr2_-_136891131 0.172 ENSMUST00000144275.1
Mkks
McKusick-Kaufman syndrome
chr10_-_81025521 0.162 ENSMUST00000144640.1
Diras1
DIRAS family, GTP-binding RAS-like 1
chr19_-_43524462 0.161 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr2_+_27009926 0.161 ENSMUST00000114005.2
ENSMUST00000114004.1
ENSMUST00000114006.1
ENSMUST00000114007.1
Cacfd1



calcium channel flower domain containing 1



chr7_+_127777095 0.156 ENSMUST00000144406.1
Setd1a
SET domain containing 1A
chr13_+_9276477 0.153 ENSMUST00000174552.1
Dip2c
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr1_-_160792908 0.152 ENSMUST00000028049.7
Rabgap1l
RAB GTPase activating protein 1-like
chr9_-_64726583 0.144 ENSMUST00000168366.1
Rab11a
RAB11a, member RAS oncogene family
chr14_-_59440779 0.142 ENSMUST00000111253.2
ENSMUST00000095775.3
ENSMUST00000161459.1
Setdb2


SET domain, bifurcated 2


chr12_+_40222758 0.140 ENSMUST00000038121.4
Gm7008
predicted gene 7008
chr12_-_40223149 0.138 ENSMUST00000171553.1
ENSMUST00000001672.5
Ifrd1

interferon-related developmental regulator 1

chr5_+_139211934 0.126 ENSMUST00000148772.1
ENSMUST00000110882.1
Sun1

Sad1 and UNC84 domain containing 1

chr4_+_140701466 0.120 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr19_+_46152505 0.118 ENSMUST00000026254.7
Gbf1
golgi-specific brefeldin A-resistance factor 1
chr15_-_89149557 0.110 ENSMUST00000088823.3
Mapk11
mitogen-activated protein kinase 11
chr17_-_83514311 0.105 ENSMUST00000167741.1
ENSMUST00000025095.7
Cox7a2l

cytochrome c oxidase subunit VIIa polypeptide 2-like

chr15_-_86186136 0.105 ENSMUST00000044332.9
Cerk
ceramide kinase
chr8_+_31111816 0.101 ENSMUST00000046941.7
Rnf122
ring finger protein 122
chr11_+_19924403 0.095 ENSMUST00000093298.5
Spred2
sprouty-related, EVH1 domain containing 2
chr9_-_110117303 0.091 ENSMUST00000136969.1
Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr7_-_19458494 0.089 ENSMUST00000085715.5
Mark4
MAP/microtubule affinity-regulating kinase 4
chr4_+_99829437 0.087 ENSMUST00000124547.1
ENSMUST00000106994.1
Efcab7

EF-hand calcium binding domain 7

chr11_+_4986824 0.073 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr10_-_81025406 0.063 ENSMUST00000055125.4
Diras1
DIRAS family, GTP-binding RAS-like 1
chr4_+_59003121 0.061 ENSMUST00000095070.3
ENSMUST00000174664.1
Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr11_+_120784257 0.058 ENSMUST00000100134.3
Gps1
G protein pathway suppressor 1
chr9_+_104569671 0.044 ENSMUST00000057742.8
Cpne4
copine IV
chr7_-_126861648 0.043 ENSMUST00000129812.1
ENSMUST00000106342.1
Ino80e

INO80 complex subunit E

chr2_-_167062981 0.040 ENSMUST00000048988.7
Znfx1
zinc finger, NFX1-type containing 1
chr2_-_168734236 0.040 ENSMUST00000109175.2
Atp9a
ATPase, class II, type 9A
chr2_+_27009936 0.038 ENSMUST00000133807.1
Cacfd1
calcium channel flower domain containing 1
chr8_+_85080939 0.035 ENSMUST00000140621.1
BC056474
cDNA sequence BC056474
chr8_-_70476911 0.029 ENSMUST00000066597.5
ENSMUST00000166976.1
Klhl26

kelch-like 26

chr17_+_37045963 0.028 ENSMUST00000025338.9
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr5_+_124112297 0.026 ENSMUST00000024470.6
ENSMUST00000119269.1
Ogfod2

2-oxoglutarate and iron-dependent oxygenase domain containing 2

chr10_-_81496313 0.015 ENSMUST00000118498.1
Ncln
nicalin homolog (zebrafish)
chr11_+_19924354 0.013 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chrX_-_73966329 0.011 ENSMUST00000114372.2
ENSMUST00000033761.6
Hcfc1

host cell factor C1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 0.6 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.2 0.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 1.2 GO:0042711 maternal behavior(GO:0042711)
0.1 0.4 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.1 0.2 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.3 GO:0046618 drug export(GO:0046618)
0.1 0.3 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.2 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.0 0.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0072610 interleukin-12 secretion(GO:0072610) regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 1.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.8 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.8 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:1990023 mitotic spindle midzone(GO:1990023)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.2 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 0.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0016749 N-succinyltransferase activity(GO:0016749)