Motif ID: Irf4

Z-value: 0.690


Transcription factors associated with Irf4:

Gene SymbolEntrez IDGene Name
Irf4 ENSMUSG00000021356.3 Irf4



Activity profile for motif Irf4.

activity profile for motif Irf4


Sorted Z-values histogram for motif Irf4

Sorted Z-values for motif Irf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 132 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_64090241 3.556 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090265 3.188 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr1_+_99772765 1.692 ENSMUST00000086738.3
 Cntnap5b
contactin associated protein-like 5B
chr17_-_81649607 1.049 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr5_-_66514815 0.998 ENSMUST00000161879.1
ENSMUST00000159357.1
 Apbb2

amyloid beta (A4) precursor protein-binding, family B, member 2

chr1_-_84935089 0.964 ENSMUST00000027422.5
 Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
chr6_+_40110251 0.951 ENSMUST00000061740.7
 Tmem178b
transmembrane protein 178B
chr8_-_125492710 0.879 ENSMUST00000108775.1
 Sipa1l2
signal-induced proliferation-associated 1 like 2
chr6_-_49214954 0.841 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr10_-_86022325 0.839 ENSMUST00000181665.1
 A230060F14Rik
RIKEN cDNA A230060F14 gene
chr19_-_57197377 0.838 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197496 0.831 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr13_+_20090538 0.829 ENSMUST00000072519.5
 Elmo1
engulfment and cell motility 1
chr19_-_57197435 0.825 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr13_+_20090500 0.825 ENSMUST00000165249.2
 Elmo1
engulfment and cell motility 1
chr19_+_46623387 0.778 ENSMUST00000111855.4
 Wbp1l
WW domain binding protein 1 like
chr6_+_96115249 0.768 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chrX_+_159303266 0.761 ENSMUST00000112491.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr16_-_55838827 0.749 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr19_+_5568002 0.692 ENSMUST00000096318.3
 Ap5b1
adaptor-related protein complex 5, beta 1 subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.7 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0 2.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.7 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.2 1.0 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.8 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.1 0.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.6 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 0.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.5 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 0.4 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.4 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 0.3 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.1 0.3 GO:0002925 regulation of dendritic cell cytokine production(GO:0002730) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) detection of peptidoglycan(GO:0032499) negative regulation of interleukin-18 production(GO:0032701)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.3 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.3 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.2 GO:0014704 intercalated disc(GO:0014704)
0.0 0.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.7 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.3 GO:0097422 tubular endosome(GO:0097422)
0.0 0.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.7 GO:0017124 SH3 domain binding(GO:0017124)
0.3 1.0 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.0 1.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.7 GO:0050733 RS domain binding(GO:0050733)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.5 GO:0030553 cGMP binding(GO:0030553)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.4 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.3 GO:0042834 peptidoglycan binding(GO:0042834) CARD domain binding(GO:0050700)
0.0 0.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)