Motif ID: Onecut2_Onecut3

Z-value: 1.007

Transcription factors associated with Onecut2_Onecut3:

Gene SymbolEntrez IDGene Name
Onecut2 ENSMUSG00000045991.12 Onecut2
Onecut3 ENSMUSG00000045518.8 Onecut3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut2mm10_v2_chr18_+_64340225_643403640.441.1e-01Click!
Onecut3mm10_v2_chr10_+_80494835_80494873-0.283.4e-01Click!


Activity profile for motif Onecut2_Onecut3.

activity profile for motif Onecut2_Onecut3


Sorted Z-values histogram for motif Onecut2_Onecut3

Sorted Z-values for motif Onecut2_Onecut3



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut2_Onecut3

PNG image of the network

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Top targets:


Showing 1 to 20 of 180 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 4.412 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr7_-_79149042 3.363 ENSMUST00000032825.8
ENSMUST00000107409.3
 Mfge8

milk fat globule-EGF factor 8 protein

chrY_+_897782 3.159 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr18_+_57468478 2.322 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr6_+_141524379 2.282 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr13_-_56895737 2.154 ENSMUST00000022023.6
ENSMUST00000109871.1
 Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr15_-_42676967 2.130 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr11_-_101785252 2.085 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr17_+_79051906 2.065 ENSMUST00000040789.4
 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr4_+_109343029 2.007 ENSMUST00000030281.5
 Eps15
epidermal growth factor receptor pathway substrate 15
chr1_+_167598450 1.878 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr9_+_55326913 1.671 ENSMUST00000085754.3
ENSMUST00000034862.4
 AI118078

expressed sequence AI118078

chr11_+_78499087 1.516 ENSMUST00000017488.4
 Vtn
vitronectin
chr4_+_145510759 1.482 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr14_+_76504185 1.463 ENSMUST00000177207.1
 Tsc22d1
TSC22 domain family, member 1
chr6_+_29694204 1.342 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr3_+_19957037 1.308 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
 Cp


ceruloplasmin


chr3_+_136670076 1.303 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr1_+_167598384 1.247 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr14_+_13454010 1.247 ENSMUST00000112656.2
 Synpr
synaptoporin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0048663 neuron fate commitment(GO:0048663)
0.8 3.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.1 3.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.6 3.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.2 2.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 2.2 GO:0006828 manganese ion transport(GO:0006828)
0.7 2.1 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.7 2.1 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.3 2.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.2 2.0 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.5 1.5 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.2 1.5 GO:0097421 liver regeneration(GO:0097421)
0.1 1.3 GO:0006825 copper ion transport(GO:0006825)
0.0 1.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.2 1.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3 0.9 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.9 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 0.8 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1 0.8 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1 0.7 GO:0048625 myoblast fate commitment(GO:0048625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.9 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 2.5 GO:0005902 microvillus(GO:0005902)
0.0 2.2 GO:0005801 cis-Golgi network(GO:0005801)
0.2 2.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 1.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 1.5 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 1.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.9 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.9 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0030894 replisome(GO:0030894)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.5 3.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.3 3.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.6 2.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 2.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 2.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 2.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 2.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.3 1.5 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 1.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 0.9 GO:0004942 anaphylatoxin receptor activity(GO:0004942)
0.0 0.9 GO:0005179 hormone activity(GO:0005179)
0.2 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.5 GO:0015616 DNA translocase activity(GO:0015616)