Motif ID: Brca1

Z-value: 0.580


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_1015518930.068.4e-01Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Showing 1 to 20 of 197 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 1.313 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chrX_+_169685191 1.017 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr3_+_5218546 0.401 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr8_-_11008458 0.367 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr3_+_5218516 0.366 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr3_-_95882031 0.349 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr6_-_23248264 0.348 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr19_-_24225015 0.313 ENSMUST00000099558.4
 Tjp2
tight junction protein 2
chr3_+_5218589 0.301 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr5_+_66968961 0.300 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr11_-_109472611 0.268 ENSMUST00000168740.1
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr18_-_15063560 0.262 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr10_-_42276744 0.248 ENSMUST00000105502.1
ENSMUST00000105501.1
 Foxo3

forkhead box O3

chr16_-_11066141 0.247 ENSMUST00000162323.1
 Litaf
LPS-induced TN factor
chr3_+_109573907 0.246 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr10_-_42276688 0.246 ENSMUST00000175881.1
ENSMUST00000056974.3
 Foxo3

forkhead box O3

chr5_+_66968559 0.244 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr12_-_24493656 0.235 ENSMUST00000073088.2
 Gm16372
predicted pseudogene 16372
chr11_-_101171302 0.225 ENSMUST00000164474.1
ENSMUST00000043397.7
 Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr17_-_34028044 0.219 ENSMUST00000045467.7
ENSMUST00000114303.3
 H2-Ke6

H2-K region expressed gene 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0048663 neuron fate commitment(GO:0048663)
0.0 1.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.5 GO:1905206 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0 0.4 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.3 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 0.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.3 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.3 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.3 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.3 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.2 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.3 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.3 GO:0005921 gap junction(GO:0005921)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 0.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.0 GO:0005785 signal recognition particle receptor complex(GO:0005785)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.2 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.2 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.1 GO:0015183 sulfur amino acid transmembrane transporter activity(GO:0000099) L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)