Motif ID: Hes1
Z-value: 0.775
Transcription factors associated with Hes1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hes1 | ENSMUSG00000022528.7 | Hes1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hes1 | mm10_v2_chr16_+_30065333_30065351 | 0.21 | 4.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.6 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
0.5 | 1.6 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
0.5 | 4.8 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
0.5 | 1.9 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
0.4 | 1.1 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
0.4 | 1.1 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
0.3 | 3.4 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
0.3 | 1.5 | GO:0019336 | phenol-containing compound catabolic process(GO:0019336) |
0.2 | 0.7 | GO:0043379 | memory T cell differentiation(GO:0043379) |
0.2 | 0.8 | GO:0006680 | glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490) |
0.2 | 0.6 | GO:0014042 | positive regulation of neuron maturation(GO:0014042) |
0.1 | 0.6 | GO:0048133 | NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728) |
0.1 | 0.8 | GO:0001842 | neural fold formation(GO:0001842) |
0.1 | 0.3 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
0.1 | 0.7 | GO:0035087 | siRNA loading onto RISC involved in RNA interference(GO:0035087) |
0.1 | 0.3 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255) |
0.1 | 0.4 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
0.1 | 0.5 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
0.1 | 0.6 | GO:0034350 | regulation of glial cell apoptotic process(GO:0034350) |
0.1 | 1.6 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
0.1 | 0.5 | GO:0060017 | parathyroid gland development(GO:0060017) |
0.1 | 0.4 | GO:0035984 | response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984) |
0.1 | 0.3 | GO:0003360 | brainstem development(GO:0003360) |
0.1 | 0.2 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
0.1 | 0.5 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.1 | 0.6 | GO:0071763 | nuclear membrane organization(GO:0071763) |
0.1 | 0.2 | GO:2000054 | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054) |
0.1 | 0.2 | GO:1903722 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) regulation of centriole elongation(GO:1903722) |
0.1 | 0.2 | GO:0060032 | notochord regression(GO:0060032) |
0.0 | 0.2 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
0.0 | 0.1 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) |
0.0 | 0.2 | GO:0072757 | cellular response to camptothecin(GO:0072757) |
0.0 | 0.1 | GO:0006553 | lysine metabolic process(GO:0006553) |
0.0 | 0.1 | GO:0018008 | N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201) |
0.0 | 0.3 | GO:0015677 | copper ion import(GO:0015677) |
0.0 | 0.8 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
0.0 | 0.2 | GO:0090234 | cellular response to testosterone stimulus(GO:0071394) regulation of kinetochore assembly(GO:0090234) |
0.0 | 1.3 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
0.0 | 0.5 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
0.0 | 0.3 | GO:0061092 | involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
0.0 | 0.4 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
0.0 | 1.5 | GO:0033014 | porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014) |
0.0 | 0.1 | GO:0097167 | circadian regulation of translation(GO:0097167) |
0.0 | 0.4 | GO:0007220 | Notch receptor processing(GO:0007220) |
0.0 | 0.7 | GO:0006415 | translational termination(GO:0006415) |
0.0 | 0.2 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
0.0 | 0.2 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
0.0 | 0.1 | GO:0035622 | intrahepatic bile duct development(GO:0035622) |
0.0 | 0.3 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
0.0 | 0.3 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
0.0 | 0.1 | GO:0060468 | prevention of polyspermy(GO:0060468) |
0.0 | 0.7 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
0.0 | 0.1 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
0.0 | 0.1 | GO:0007603 | phototransduction, visible light(GO:0007603) |
0.0 | 0.3 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
0.0 | 0.3 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
0.0 | 0.1 | GO:0060178 | regulation of exocyst localization(GO:0060178) |
0.0 | 0.4 | GO:0008090 | retrograde axonal transport(GO:0008090) |
0.0 | 0.5 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 0.3 | GO:0006085 | acetyl-CoA biosynthetic process(GO:0006085) |
0.0 | 0.5 | GO:0048148 | behavioral response to cocaine(GO:0048148) |
0.0 | 0.5 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
0.0 | 0.4 | GO:0035855 | megakaryocyte development(GO:0035855) |
0.0 | 0.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.0 | 0.1 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
0.0 | 0.1 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
0.0 | 0.1 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
0.0 | 0.7 | GO:1901381 | positive regulation of potassium ion transmembrane transport(GO:1901381) |
0.0 | 0.5 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
0.0 | 0.2 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.0 | 0.5 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
0.0 | 0.4 | GO:0007020 | microtubule nucleation(GO:0007020) |
0.0 | 0.4 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
0.0 | 0.1 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
0.0 | 1.0 | GO:0015807 | L-amino acid transport(GO:0015807) |
0.0 | 0.2 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
0.0 | 0.3 | GO:0009409 | response to cold(GO:0009409) |
0.0 | 0.1 | GO:0070459 | prolactin secretion(GO:0070459) |
0.0 | 0.1 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.0 | 0.3 | GO:0002446 | neutrophil mediated immunity(GO:0002446) |
0.0 | 0.2 | GO:0034453 | microtubule anchoring(GO:0034453) |
0.0 | 0.2 | GO:0010666 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
0.0 | 0.1 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
0.0 | 0.3 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
0.0 | 0.1 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.0 | 0.1 | GO:0035729 | response to hepatocyte growth factor(GO:0035728) cellular response to hepatocyte growth factor stimulus(GO:0035729) |
0.0 | 0.1 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
0.0 | 0.1 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
0.0 | 0.1 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.7 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
0.2 | 0.7 | GO:0090537 | CERF complex(GO:0090537) |
0.1 | 0.4 | GO:0031673 | H zone(GO:0031673) |
0.1 | 0.3 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
0.1 | 3.4 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.1 | 1.5 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.1 | 0.5 | GO:0044308 | axonal spine(GO:0044308) |
0.1 | 0.2 | GO:1990597 | TRAF2-GSTP1 complex(GO:0097057) AIP1-IRE1 complex(GO:1990597) |
0.1 | 0.2 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
0.1 | 0.4 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
0.1 | 0.3 | GO:0090498 | extrinsic component of Golgi membrane(GO:0090498) |
0.1 | 0.3 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
0.1 | 0.4 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
0.1 | 0.3 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
0.0 | 0.2 | GO:1990130 | Iml1 complex(GO:1990130) |
0.0 | 0.1 | GO:0031417 | NatC complex(GO:0031417) |
0.0 | 0.5 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.0 | 0.3 | GO:0070578 | RISC-loading complex(GO:0070578) |
0.0 | 1.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
0.0 | 0.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 0.1 | GO:0034715 | pICln-Sm protein complex(GO:0034715) |
0.0 | 0.2 | GO:0033391 | chromatoid body(GO:0033391) |
0.0 | 0.2 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.2 | GO:0097542 | ciliary tip(GO:0097542) |
0.0 | 1.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 0.4 | GO:0000242 | pericentriolar material(GO:0000242) |
0.0 | 1.5 | GO:0043198 | dendritic shaft(GO:0043198) |
0.0 | 0.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.0 | 0.1 | GO:0042589 | zymogen granule membrane(GO:0042589) |
0.0 | 0.1 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
0.0 | 0.2 | GO:0035102 | PRC1 complex(GO:0035102) |
0.0 | 0.2 | GO:0043194 | axon initial segment(GO:0043194) |
0.0 | 0.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.0 | 0.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 0.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
0.0 | 0.2 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.6 | GO:0031752 | D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752) |
0.3 | 1.9 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
0.2 | 4.8 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.2 | 0.8 | GO:0070976 | calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976) |
0.2 | 0.6 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
0.2 | 0.7 | GO:0016149 | translation release factor activity, codon specific(GO:0016149) |
0.1 | 0.5 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
0.1 | 0.4 | GO:0035851 | Krueppel-associated box domain binding(GO:0035851) |
0.1 | 0.3 | GO:0004008 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
0.1 | 3.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.1 | 0.3 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
0.1 | 0.8 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
0.1 | 0.6 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
0.1 | 0.4 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) |
0.1 | 0.2 | GO:0009881 | photoreceptor activity(GO:0009881) |
0.1 | 0.5 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.1 | 0.2 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
0.1 | 0.5 | GO:0005451 | monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
0.1 | 0.5 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114) |
0.1 | 0.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.1 | 1.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
0.1 | 0.3 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.1 | 1.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.0 | 0.3 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
0.0 | 0.1 | GO:0004379 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) |
0.0 | 0.2 | GO:0005047 | signal recognition particle binding(GO:0005047) |
0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 0.2 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
0.0 | 1.1 | GO:0008009 | chemokine activity(GO:0008009) |
0.0 | 0.2 | GO:0033142 | progesterone receptor binding(GO:0033142) |
0.0 | 0.2 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
0.0 | 0.1 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
0.0 | 0.3 | GO:0032557 | pyrimidine ribonucleotide binding(GO:0032557) |
0.0 | 0.7 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
0.0 | 0.4 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.0 | 0.5 | GO:0005521 | lamin binding(GO:0005521) |
0.0 | 0.2 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
0.0 | 1.2 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.0 | 0.6 | GO:0043175 | RNA polymerase core enzyme binding(GO:0043175) |
0.0 | 0.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.0 | 1.3 | GO:0015179 | L-amino acid transmembrane transporter activity(GO:0015179) |
0.0 | 0.1 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
0.0 | 0.4 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.0 | 0.4 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
0.0 | 0.5 | GO:0034930 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131) |
0.0 | 0.1 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
0.0 | 0.2 | GO:0070411 | I-SMAD binding(GO:0070411) |
0.0 | 0.1 | GO:0089720 | caspase binding(GO:0089720) |
0.0 | 0.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.0 | 0.1 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
0.0 | 0.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 0.1 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
0.0 | 0.1 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
0.0 | 0.8 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) |
0.0 | 0.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
0.0 | 0.1 | GO:0008193 | tRNA guanylyltransferase activity(GO:0008193) |
0.0 | 0.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 0.1 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.0 | 0.4 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.0 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
0.0 | 0.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
0.0 | 0.2 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.0 | 0.3 | GO:0050681 | androgen receptor binding(GO:0050681) |