Motif ID: Hes1

Z-value: 0.775


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_300653510.214.7e-01Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_153652943 3.420 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr11_-_12026732 2.852 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026237 1.952 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_+_98348404 1.628 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr12_+_110279228 1.536 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr9_+_118478344 1.342 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chrX_-_52165252 1.336 ENSMUST00000033450.2
 Gpc4
glypican 4
chr9_+_118478182 1.238 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr17_-_87282793 1.215 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr9_-_24503127 1.135 ENSMUST00000142064.1
ENSMUST00000170356.1
 Dpy19l1

dpy-19-like 1 (C. elegans)

chr13_-_56296551 1.081 ENSMUST00000021970.9
 Cxcl14
chemokine (C-X-C motif) ligand 14
chr17_-_87282771 1.067 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr8_-_36249292 1.014 ENSMUST00000065297.5
 Lonrf1
LON peptidase N-terminal domain and ring finger 1
chr10_-_127534540 0.963 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr3_+_104638658 0.932 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr3_+_127633134 0.918 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr8_+_23139064 0.858 ENSMUST00000033947.8
 Ank1
ankyrin 1, erythroid
chr14_-_30626196 0.846 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr11_-_66525795 0.803 ENSMUST00000123454.1
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr4_-_58553553 0.790 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 3.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.9 2.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 1.9 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.5 1.6 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 1.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 1.5 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.0 1.5 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.0 1.3 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.4 1.1 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.4 1.1 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.0 1.0 GO:0015807 L-amino acid transport(GO:0015807)
0.2 0.8 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.1 0.8 GO:0001842 neural fold formation(GO:0001842)
0.0 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 0.7 GO:0043379 memory T cell differentiation(GO:0043379)
0.1 0.7 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0 0.7 GO:0006415 translational termination(GO:0006415)
0.0 0.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.7 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 0.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.2 0.7 GO:0090537 CERF complex(GO:0090537)
0.0 0.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.5 GO:0044308 axonal spine(GO:0044308)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.4 GO:0031673 H zone(GO:0031673)
0.1 0.4 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 0.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.4 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 0.3 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 3.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 1.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.5 1.6 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.1 1.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.3 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 1.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.1 GO:0008009 chemokine activity(GO:0008009)
0.2 0.8 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.1 0.8 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576)
0.2 0.7 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2 0.6 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 0.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.6 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.1 0.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)