Motif ID: Nrf1

Z-value: 2.841


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30048062_300480780.283.4e-01Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_93519499 7.129 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr11_+_86544982 4.813 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
 Tubd1



tubulin, delta 1



chr11_-_7213897 4.798 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr12_+_112146187 4.606 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr15_+_88751649 4.393 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr15_-_93595877 3.913 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr16_+_90727490 3.531 ENSMUST00000181232.1
 Gm17518
predicted gene, 17518
chr10_+_79682304 3.228 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr7_-_131362687 3.012 ENSMUST00000059438.9
 2310057M21Rik
RIKEN cDNA 2310057M21 gene
chr12_-_112511136 2.990 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr13_-_115090123 2.953 ENSMUST00000109226.3
 Pelo
pelota homolog (Drosophila)
chr1_+_24005505 2.887 ENSMUST00000181961.1
 Gm26524
predicted gene, 26524
chr8_-_9976294 2.735 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chr4_+_103313806 2.664 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr10_+_79682169 2.502 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr9_+_21616230 2.414 ENSMUST00000174008.1
 Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr8_+_83389878 2.368 ENSMUST00000109831.2
 Clgn
calmegin
chr8_-_124897685 2.355 ENSMUST00000098312.2
 Exoc8
exocyst complex component 8
chr16_-_45158453 2.330 ENSMUST00000181750.1
 Slc35a5
solute carrier family 35, member A5
chr6_-_52012476 2.329 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 525 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 11.0 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
1.1 7.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 6.3 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.8 5.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
1.1 4.6 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
1.1 4.5 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.8 4.5 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.9 3.8 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.4 3.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 3.4 GO:0007020 microtubule nucleation(GO:0007020)
0.1 3.2 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
1.0 3.0 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 3.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.2 2.9 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.2 2.9 GO:0097284 hepatocyte apoptotic process(GO:0097284)
0.0 2.9 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 2.9 GO:0007416 synapse assembly(GO:0007416)
0.7 2.7 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.5 2.7 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.2 2.6 GO:0048484 enteric nervous system development(GO:0048484)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 236 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 26.7 GO:0005739 mitochondrion(GO:0005739)
0.0 10.9 GO:0031965 nuclear membrane(GO:0031965)
0.0 8.6 GO:0005874 microtubule(GO:0005874)
0.5 7.3 GO:0043196 varicosity(GO:0043196)
0.1 7.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 5.4 GO:0016235 aggresome(GO:0016235)
0.0 5.2 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.2 4.8 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0 4.5 GO:0005635 nuclear envelope(GO:0005635)
0.8 4.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 4.2 GO:0000242 pericentriolar material(GO:0000242)
0.5 3.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 3.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 3.1 GO:0000145 exocyst(GO:0000145)
0.0 3.0 GO:0036064 ciliary basal body(GO:0036064)
0.2 2.8 GO:0031932 TORC2 complex(GO:0031932)
0.1 2.8 GO:0016580 Sin3 complex(GO:0016580)
0.1 2.7 GO:0014704 intercalated disc(GO:0014704)
0.0 2.7 GO:0000139 Golgi membrane(GO:0000139)
0.3 2.6 GO:0070688 MLL5-L complex(GO:0070688)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 323 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.0 GO:0008270 zinc ion binding(GO:0008270)
0.0 7.8 GO:0003924 GTPase activity(GO:0003924)
0.6 7.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.6 7.1 GO:0030957 Tat protein binding(GO:0030957)
0.4 6.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 6.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 5.9 GO:0008013 beta-catenin binding(GO:0008013)
0.3 5.8 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.8 4.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.9 4.4 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 4.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 4.2 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.5 3.6 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 3.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 3.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.2 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0 3.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 3.1 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0 3.1 GO:0004222 metalloendopeptidase activity(GO:0004222)