Motif ID: Lhx5_Lmx1b_Lhx1

Z-value: 0.951

Transcription factors associated with Lhx5_Lmx1b_Lhx1:

Gene SymbolEntrez IDGene Name
Lhx1 ENSMUSG00000018698.9 Lhx1
Lhx5 ENSMUSG00000029595.7 Lhx5
Lmx1b ENSMUSG00000038765.7 Lmx1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx5mm10_v2_chr5_+_120431770_1204319050.352.1e-01Click!
Lhx1mm10_v2_chr11_-_84525514_845255420.302.9e-01Click!
Lmx1bmm10_v2_chr2_-_33640480_33640511-0.019.7e-01Click!


Activity profile for motif Lhx5_Lmx1b_Lhx1.

activity profile for motif Lhx5_Lmx1b_Lhx1


Sorted Z-values histogram for motif Lhx5_Lmx1b_Lhx1

Sorted Z-values for motif Lhx5_Lmx1b_Lhx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_93595877 8.558 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr18_-_66860458 4.435 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr4_+_102589687 3.949 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr3_+_121953213 3.697 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr11_-_87359011 2.875 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr15_-_67113909 2.654 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr10_+_37139558 2.174 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr2_-_165368723 2.023 ENSMUST00000141140.1
ENSMUST00000103085.1
 Zfp663

zinc finger protein 663

chrX_-_143933089 1.845 ENSMUST00000087313.3
 Dcx
doublecortin
chr18_-_56975333 1.679 ENSMUST00000139243.2
ENSMUST00000025488.8
 C330018D20Rik

RIKEN cDNA C330018D20 gene

chr7_+_66365905 1.544 ENSMUST00000107486.1
 Gm10974
predicted gene 10974
chr2_+_68104671 1.502 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr15_-_103215285 1.456 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr1_+_72284367 1.426 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr4_+_102421518 1.405 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr1_-_172027269 1.286 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr8_-_67910911 1.251 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3
chr13_+_46502113 1.188 ENSMUST00000119341.1
 Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr13_-_102905740 1.143 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_+_67833235 1.126 ENSMUST00000060609.7
 Gm10037
predicted gene 10037

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 8.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.5 5.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.9 4.4 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.3 2.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 2.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 2.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 1.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.4 1.3 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.2 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.2 1.0 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.3 0.9 GO:0042420 dopamine catabolic process(GO:0042420)
0.3 0.9 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 0.8 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.8 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.7 GO:0080111 DNA demethylation(GO:0080111)
0.2 0.6 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.2 0.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.6 GO:0060046 regulation of acrosome reaction(GO:0060046)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0031965 nuclear membrane(GO:0031965)
0.2 5.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.5 GO:0010369 chromocenter(GO:0010369)
0.3 1.3 GO:0060187 cell pole(GO:0060187)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.1 0.7 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 0.6 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.3 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.1 0.2 GO:0005594 collagen type IX trimer(GO:0005594)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 GO:0043015 gamma-tubulin binding(GO:0043015)
1.5 4.4 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 4.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 2.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.5 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 1.3 GO:0030275 LRR domain binding(GO:0030275)
0.0 1.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.0 GO:0003777 microtubule motor activity(GO:0003777)
0.2 0.9 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.1 0.7 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.7 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.1 0.6 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)