Motif ID: Glis3

Z-value: 1.375


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_286801220.781.1e-03Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 119 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_108660616 9.162 ENSMUST00000032194.4
Bhlhe40
basic helix-loop-helix family, member e40
chr8_+_70501116 5.891 ENSMUST00000127983.1
Crlf1
cytokine receptor-like factor 1
chr4_+_144892813 5.502 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr6_+_17463749 4.724 ENSMUST00000115443.1
Met
met proto-oncogene
chr6_+_108660772 4.421 ENSMUST00000163617.1
Bhlhe40
basic helix-loop-helix family, member e40
chr4_+_144893077 4.351 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_17463927 4.075 ENSMUST00000115442.1
Met
met proto-oncogene
chr6_+_17463826 3.504 ENSMUST00000140070.1
Met
met proto-oncogene
chr4_+_144893127 3.441 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr14_-_55560340 2.307 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr7_-_142657466 2.201 ENSMUST00000097936.2
ENSMUST00000000033.5
Igf2

insulin-like growth factor 2

chr3_+_52268337 2.109 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr13_+_38345716 2.075 ENSMUST00000171970.1
Bmp6
bone morphogenetic protein 6
chr2_+_32646586 1.682 ENSMUST00000009705.7
ENSMUST00000167841.1
Eng

endoglin

chr7_+_45017953 1.598 ENSMUST00000044111.7
Rras
Harvey rat sarcoma oncogene, subgroup R
chr10_-_68278713 1.349 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr13_+_119690462 1.271 ENSMUST00000179869.1
Hmgcs1
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
chr11_+_97663366 1.268 ENSMUST00000044730.5
Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr11_+_5861886 1.218 ENSMUST00000102923.3
Aebp1
AE binding protein 1
chr14_-_62292959 1.166 ENSMUST00000063169.8
Dleu7
deleted in lymphocytic leukemia, 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 13.6 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
1.2 13.3 GO:0042572 retinol metabolic process(GO:0042572)
1.3 12.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
1.0 5.9 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.3 2.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 2.1 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.3 2.1 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.6 1.7 GO:0003032 detection of oxygen(GO:0003032)
0.0 1.6 GO:0060325 face morphogenesis(GO:0060325)
0.1 1.3 GO:0060613 fat pad development(GO:0060613)
0.0 1.3 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 1.1 GO:0016578 histone deubiquitination(GO:0016578)
0.0 1.0 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.9 GO:0043353 enucleate erythrocyte differentiation(GO:0043353) hydrogen sulfide biosynthetic process(GO:0070814)
0.1 0.9 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.1 0.9 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.9 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.3 0.8 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366)
0.0 0.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 0.7 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 12.6 GO:0005730 nucleolus(GO:0005730)
2.0 5.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.1 GO:0000124 SAGA complex(GO:0000124)
0.0 1.0 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 0.9 GO:0071203 WASH complex(GO:0071203)
0.0 0.9 GO:0070469 respiratory chain(GO:0070469)
0.1 0.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.7 GO:0005844 polysome(GO:0005844)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0033503 HULC complex(GO:0033503)
0.0 0.6 GO:0016589 NURF complex(GO:0016589)
0.0 0.6 GO:0001650 fibrillar center(GO:0001650)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.2 GO:0031084 BLOC-2 complex(GO:0031084)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 13.6 GO:0043426 MRF binding(GO:0043426)
1.9 13.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
3.1 12.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.8 5.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 2.6 GO:0019003 GDP binding(GO:0019003)
0.1 2.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 2.1 GO:0070700 BMP receptor binding(GO:0070700)
0.1 2.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.6 1.7 GO:0005534 galactose binding(GO:0005534)
0.2 1.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.9 GO:0015265 urea channel activity(GO:0015265)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.9 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.8 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.2 0.7 GO:2001069 glycogen binding(GO:2001069)
0.1 0.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)