Motif ID: Klf8

Z-value: 0.733


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.869.4e-05Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_32222233 1.724 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr6_+_114131229 1.674 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr3_+_90541146 1.364 ENSMUST00000107333.1
ENSMUST00000107331.1
ENSMUST00000098910.2
 S100a16


S100 calcium binding protein A16


chr7_-_31055594 1.180 ENSMUST00000039909.6
 Fxyd1
FXYD domain-containing ion transport regulator 1
chr7_-_31054815 1.176 ENSMUST00000071697.4
ENSMUST00000108110.3
 Fxyd1

FXYD domain-containing ion transport regulator 1

chr2_-_165473187 1.087 ENSMUST00000029208.8
ENSMUST00000109279.2
 Slc13a3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr9_-_82975475 1.065 ENSMUST00000034787.5
 Phip
pleckstrin homology domain interacting protein
chr1_-_186705980 1.051 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr7_-_142657466 1.014 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr16_+_30599717 0.965 ENSMUST00000059078.3
 Fam43a
family with sequence similarity 43, member A
chr2_-_36105271 0.945 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr7_+_25306085 0.927 ENSMUST00000119703.1
ENSMUST00000108409.1
 Tmem145

transmembrane protein 145

chr7_-_127026479 0.881 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr18_-_78206408 0.816 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr5_+_139423151 0.812 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr11_-_102897146 0.801 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr7_+_126847908 0.782 ENSMUST00000147257.1
ENSMUST00000139174.1
 Doc2a

double C2, alpha

chr16_+_93683184 0.774 ENSMUST00000039620.6
 Cbr3
carbonyl reductase 3
chr7_-_31042078 0.767 ENSMUST00000162116.1
ENSMUST00000159924.1
ENSMUST00000159753.1
ENSMUST00000160689.1
ENSMUST00000162733.1
ENSMUST00000162087.1
ENSMUST00000009831.7
 Fxyd5






FXYD domain-containing ion transport regulator 5






chr17_+_34898931 0.761 ENSMUST00000097342.3
ENSMUST00000013931.5
 Ehmt2

euchromatic histone lysine N-methyltransferase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.4 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.5 2.4 GO:1904426 positive regulation of GTP binding(GO:1904426)
0.0 1.8 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 1.7 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.3 1.5 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 1.4 GO:0051592 response to calcium ion(GO:0051592)
0.4 1.3 GO:0036166 phenotypic switching(GO:0036166)
0.3 1.1 GO:0006842 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746)
0.1 1.1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.2 1.0 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 1.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 0.9 GO:0019236 response to pheromone(GO:0019236)
0.2 0.9 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.2 0.9 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.9 GO:0042182 ketone catabolic process(GO:0042182)
0.1 0.9 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.9 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.2 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.8 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.1 0.8 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.4 GO:0005604 basement membrane(GO:0005604)
0.3 1.3 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 1.0 GO:0031415 NatA complex(GO:0031415)
0.2 0.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 0.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.8 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.0 0.8 GO:0070469 respiratory chain(GO:0070469)
0.0 0.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 0.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.6 GO:0005844 polysome(GO:0005844)
0.1 0.5 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.5 GO:0000407 pre-autophagosomal structure(GO:0000407)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.6 1.7 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.2 1.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 1.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.4 1.1 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.3 1.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 1.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 1.0 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 0.8 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.8 GO:0015265 urea channel activity(GO:0015265)
0.1 0.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.8 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.2 0.7 GO:0005534 galactose binding(GO:0005534)
0.2 0.7 GO:0005118 sevenless binding(GO:0005118)