Motif ID: Sox17

Z-value: 0.592


Transcription factors associated with Sox17:

Gene SymbolEntrez IDGene Name
Sox17 ENSMUSG00000025902.7 Sox17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox17mm10_v2_chr1_-_4496363_4496389-0.612.2e-02Click!


Activity profile for motif Sox17.

activity profile for motif Sox17


Sorted Z-values histogram for motif Sox17

Sorted Z-values for motif Sox17



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox17

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_144209471 3.054 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209448 3.039 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr6_-_144209558 2.927 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr2_-_57113053 2.273 ENSMUST00000112627.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr11_-_110095937 1.666 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
 Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr14_+_68083853 1.397 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr15_+_74721193 1.238 ENSMUST00000070923.1
 Them6
thioesterase superfamily member 6
chr11_-_110095974 1.223 ENSMUST00000100287.2
 Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr1_-_40085823 1.220 ENSMUST00000181756.1
 Gm16894
predicted gene, 16894
chr2_+_52857844 0.958 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr2_+_80617045 0.870 ENSMUST00000028384.4
 Dusp19
dual specificity phosphatase 19
chr11_-_11970540 0.802 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr9_-_75597643 0.798 ENSMUST00000164100.1
 Tmod2
tropomodulin 2
chr13_+_54071815 0.767 ENSMUST00000021930.8
 Sfxn1
sideroflexin 1
chr15_+_85205949 0.766 ENSMUST00000057410.7
ENSMUST00000109432.3
 Fbln1

fibulin 1

chr7_-_98112618 0.744 ENSMUST00000153657.1
 Myo7a
myosin VIIA
chr2_+_102659213 0.678 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr5_+_26817357 0.603 ENSMUST00000071500.6
 Dpp6
dipeptidylpeptidase 6
chr11_+_104282371 0.589 ENSMUST00000106988.1
ENSMUST00000106989.1
 Mapt

microtubule-associated protein tau

chr2_-_15049254 0.545 ENSMUST00000028034.8
ENSMUST00000114713.1
 Nsun6

NOL1/NOP2/Sun domain family member 6

chr14_+_73142591 0.544 ENSMUST00000170368.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr3_-_153725062 0.540 ENSMUST00000064460.5
 St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr6_-_23248264 0.525 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr8_+_69822429 0.518 ENSMUST00000164890.1
ENSMUST00000034325.4
 Lpar2

lysophosphatidic acid receptor 2

chr14_+_31134853 0.484 ENSMUST00000090212.4
 Nt5dc2
5'-nucleotidase domain containing 2
chr14_+_73142490 0.451 ENSMUST00000170370.1
ENSMUST00000164822.1
ENSMUST00000165429.1
 Rcbtb2


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2


chr4_-_119173849 0.443 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
 Zfp691


zinc finger protein 691


chr9_+_57521232 0.404 ENSMUST00000000090.6
 Cox5a
cytochrome c oxidase subunit Va
chr10_-_128176568 0.395 ENSMUST00000092033.2
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr12_+_24708241 0.391 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr4_-_131937165 0.389 ENSMUST00000155990.1
 Epb4.1
erythrocyte protein band 4.1
chr3_+_101377074 0.375 ENSMUST00000043983.5
 Igsf3
immunoglobulin superfamily, member 3
chr7_+_102210335 0.369 ENSMUST00000140631.1
ENSMUST00000120879.1
ENSMUST00000146996.1
 Pgap2


post-GPI attachment to proteins 2


chr7_+_16959714 0.340 ENSMUST00000038163.6
 Pnmal1
PNMA-like 1
chr9_+_108392820 0.331 ENSMUST00000035234.4
 1700102P08Rik
RIKEN cDNA 1700102P08 gene
chr16_-_18413452 0.329 ENSMUST00000165430.1
ENSMUST00000147720.1
 Comt

catechol-O-methyltransferase

chr7_-_141613712 0.320 ENSMUST00000181275.1
 Gm16982
predicted gene, 16982
chr10_+_94575257 0.319 ENSMUST00000121471.1
 Tmcc3
transmembrane and coiled coil domains 3
chr6_-_148944750 0.318 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chrX_+_20703906 0.318 ENSMUST00000033383.2
 Usp11
ubiquitin specific peptidase 11
chr9_+_3335470 0.264 ENSMUST00000053407.5
 Alkbh8
alkB, alkylation repair homolog 8 (E. coli)
chr8_+_107150621 0.242 ENSMUST00000034400.3
 Cyb5b
cytochrome b5 type B
chr4_-_135971894 0.234 ENSMUST00000105852.1
 Lypla2
lysophospholipase 2
chr14_-_121698417 0.228 ENSMUST00000040700.7
 Dock9
dedicator of cytokinesis 9
chr18_-_33213766 0.219 ENSMUST00000119991.1
ENSMUST00000118990.1
 Stard4

StAR-related lipid transfer (START) domain containing 4

chr7_-_102210120 0.218 ENSMUST00000070165.5
 Nup98
nucleoporin 98
chr2_-_4141128 0.215 ENSMUST00000154360.1
ENSMUST00000141488.1
ENSMUST00000155091.1
 1700080N15Rik


RIKEN cDNA 1700080N15 gene


chr5_-_107597577 0.203 ENSMUST00000100949.3
ENSMUST00000078021.6
 Glmn

glomulin, FKBP associated protein

chr17_-_6621267 0.192 ENSMUST00000115772.3
 Tmem181c-ps
transmembrane protein 181C, pseudogene
chr18_+_80255227 0.187 ENSMUST00000123750.1
 Pqlc1
PQ loop repeat containing 1
chr8_-_60954726 0.184 ENSMUST00000110302.1
 Clcn3
chloride channel 3
chr1_+_171503410 0.182 ENSMUST00000081527.1
 Alyref2
Aly/REF export factor 2
chr8_+_71887264 0.176 ENSMUST00000034259.7
 Zfp709
zinc finger protein 709
chr5_-_107597533 0.171 ENSMUST00000124140.1
 Glmn
glomulin, FKBP associated protein
chr11_-_59449913 0.166 ENSMUST00000136436.1
ENSMUST00000150297.1
 Snap47

synaptosomal-associated protein, 47

chr17_-_23564117 0.139 ENSMUST00000095606.3
 Zfp213
zinc finger protein 213
chr10_+_11609256 0.137 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr7_+_126976338 0.137 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr12_-_84970814 0.115 ENSMUST00000165886.1
ENSMUST00000167448.1
ENSMUST00000043169.7
 Arel1


apoptosis resistant E3 ubiquitin protein ligase 1


chr12_-_84400851 0.098 ENSMUST00000117286.1
 Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
chr12_-_84400929 0.094 ENSMUST00000122194.1
 Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
chr8_-_94098811 0.089 ENSMUST00000034206.4
 Bbs2
Bardet-Biedl syndrome 2 (human)
chr11_-_51606840 0.083 ENSMUST00000074669.3
ENSMUST00000101249.2
ENSMUST00000109103.3
 Hnrnpab


heterogeneous nuclear ribonucleoprotein A/B


chr18_+_60560730 0.053 ENSMUST00000025506.6
 Rbm22
RNA binding motif protein 22
chr5_-_115272883 0.052 ENSMUST00000040555.8
ENSMUST00000112096.2
ENSMUST00000112097.1
 Rnf10


ring finger protein 10


chr12_+_51348265 0.048 ENSMUST00000119211.1
 G2e3
G2/M-phase specific E3 ubiquitin ligase
chr10_+_93453382 0.044 ENSMUST00000016033.7
 Lta4h
leukotriene A4 hydrolase
chr18_-_33213832 0.040 ENSMUST00000025236.2
 Stard4
StAR-related lipid transfer (START) domain containing 4
chrX_+_123103546 0.028 ENSMUST00000113348.1
 3110007F17Rik
RIKEN cDNA 3110007F17 gene
chr7_+_29238434 0.020 ENSMUST00000108237.1
 Yif1b
Yip1 interacting factor homolog B (S. cerevisiae)
chr2_-_66410064 0.019 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr2_-_180889660 0.015 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr17_-_55712571 0.014 ENSMUST00000086876.5
 Pot1b
protection of telomeres 1B
chrX_+_123103489 0.009 ENSMUST00000113343.1
 3110007F17Rik
RIKEN cDNA 3110007F17 gene
chr5_-_104021799 0.007 ENSMUST00000119025.1
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr2_-_142901506 0.007 ENSMUST00000043589.7
 Kif16b
kinesin family member 16B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 9.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.6 2.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.5 1.4 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.3 0.8 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.8 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.7 GO:0048563 post-embryonic organ morphogenesis(GO:0048563)
0.1 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.2 GO:0048388 endosomal lumen acidification(GO:0048388) synaptic vesicle lumen acidification(GO:0097401)
0.1 0.9 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.4 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0 0.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.4 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.6 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.2 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) telomere localization(GO:0034397)
0.0 0.3 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.4 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.3 GO:0034433 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.0 0.8 GO:0006826 iron ion transport(GO:0006826)
0.0 0.6 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.2 GO:0050658 nucleic acid transport(GO:0050657) RNA transport(GO:0050658) mRNA transport(GO:0051028) establishment of RNA localization(GO:0051236)
0.0 0.1 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.2 GO:0030813 positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)
0.0 2.9 GO:0006869 lipid transport(GO:0006869)
0.0 0.4 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.3 0.8 GO:0071953 fibrinogen complex(GO:0005577) elastic fiber(GO:0071953)
0.1 0.7 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 0.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.6 GO:0045298 tubulin complex(GO:0045298)
0.1 8.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 0.8 GO:0070051 fibrinogen binding(GO:0070051)
0.1 0.4 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.4 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.5 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 2.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.4 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 2.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 9.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0019992 CDP-alcohol phosphatidyltransferase activity(GO:0017169) diacylglycerol binding(GO:0019992)
0.0 1.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)