Motif ID: Nkx2-4

Z-value: 0.804


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.303.0e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_178798438 5.653 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr4_-_136892867 3.653 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr13_-_66852017 1.874 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr15_+_99055164 1.836 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr3_+_52268337 1.687 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr2_+_169633517 1.191 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr2_+_169632996 1.188 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr15_-_26895049 1.025 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr10_-_26373956 0.929 ENSMUST00000105519.3
ENSMUST00000040219.6
 L3mbtl3

l(3)mbt-like 3 (Drosophila)

chr12_+_38781093 0.878 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr3_-_59220150 0.874 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr13_+_65512678 0.843 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr13_-_105271039 0.842 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr2_+_140170641 0.811 ENSMUST00000044825.4
 Ndufaf5
NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
chr9_-_71896047 0.752 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr5_+_89027959 0.702 ENSMUST00000130041.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr12_+_38780817 0.682 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr2_-_147186389 0.580 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr5_+_89028035 0.516 ENSMUST00000113216.2
ENSMUST00000134303.1
 Slc4a4

solute carrier family 4 (anion exchanger), member 4

chr8_+_31091593 0.469 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr3_+_96696379 0.468 ENSMUST00000107076.3
 Pias3
protein inhibitor of activated STAT 3
chr8_+_66860215 0.408 ENSMUST00000118009.1
 Naf1
nuclear assembly factor 1 homolog (S. cerevisiae)
chr9_+_108560422 0.400 ENSMUST00000081111.8
 Impdh2
inosine 5'-phosphate dehydrogenase 2
chr6_+_123229843 0.367 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
 Clec4n


C-type lectin domain family 4, member n


chr13_+_108316395 0.363 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr6_+_134929089 0.347 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr2_+_156840966 0.310 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr7_-_44670820 0.306 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr18_+_36952621 0.275 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr12_+_69963452 0.274 ENSMUST00000110560.1
 Gm3086
predicted gene 3086
chr18_-_3281036 0.274 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
 Crem


cAMP responsive element modulator


chr6_+_94500313 0.268 ENSMUST00000061118.8
 Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr10_+_42502197 0.265 ENSMUST00000105499.1
 Snx3
sorting nexin 3
chr12_+_105685352 0.261 ENSMUST00000051934.5
 Gskip
GSK3B interacting protein
chr11_+_98863610 0.255 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr9_-_122310921 0.252 ENSMUST00000180685.1
 Gm26797
predicted gene, 26797
chr13_+_3478226 0.251 ENSMUST00000181708.1
ENSMUST00000180836.1
ENSMUST00000180567.1
 2810429I04Rik


RIKEN cDNA 2810429I04 gene


chr2_+_25180737 0.246 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr6_-_122609964 0.236 ENSMUST00000032211.4
 Gdf3
growth differentiation factor 3
chr11_+_110968016 0.235 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr16_+_32419696 0.214 ENSMUST00000014220.8
ENSMUST00000080316.7
 Tctex1d2

Tctex1 domain containing 2

chr19_-_6969746 0.174 ENSMUST00000025912.8
 Plcb3
phospholipase C, beta 3
chr15_-_100669512 0.172 ENSMUST00000182574.1
ENSMUST00000182775.1
 Bin2

bridging integrator 2

chr11_-_103697661 0.168 ENSMUST00000107013.2
 Gosr2
golgi SNAP receptor complex member 2
chr15_-_100669535 0.163 ENSMUST00000183211.1
 Bin2
bridging integrator 2
chr10_+_128232065 0.150 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
 Timeless




timeless circadian clock 1




chr15_-_100669496 0.150 ENSMUST00000182814.1
ENSMUST00000182068.1
 Bin2

bridging integrator 2

chr1_-_118311132 0.136 ENSMUST00000027623.7
 Tsn
translin
chr10_+_4611971 0.134 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr17_+_16972910 0.130 ENSMUST00000071374.5
 BC002059
cDNA sequence BC002059
chr11_+_49247462 0.128 ENSMUST00000109194.1
 Mgat1
mannoside acetylglucosaminyltransferase 1
chr19_+_55741810 0.127 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chrX_+_101383726 0.123 ENSMUST00000119190.1
 Gjb1
gap junction protein, beta 1
chr6_+_29398920 0.122 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr6_+_134929118 0.121 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr8_+_46490968 0.112 ENSMUST00000110372.1
ENSMUST00000130563.1
 Acsl1

acyl-CoA synthetase long-chain family member 1

chr7_-_100932140 0.100 ENSMUST00000107032.1
 Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr8_+_11556061 0.098 ENSMUST00000054399.4
 Ing1
inhibitor of growth family, member 1
chr6_-_97060407 0.094 ENSMUST00000089295.4
 Fam19a4
family with sequence similarity 19, member A4
chr4_-_108848619 0.091 ENSMUST00000164855.1
 A730015C16Rik
RIKEN cDNA A730015C16 gene
chr12_-_105685235 0.089 ENSMUST00000041055.7
 Atg2b
autophagy related 2B
chr17_+_70522149 0.087 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr8_+_77549393 0.086 ENSMUST00000056237.8
ENSMUST00000118622.1
 Prmt10

protein arginine methyltransferase 10 (putative)

chr12_+_88360801 0.081 ENSMUST00000166940.1
 Adck1
aarF domain containing kinase 1
chr7_-_84679346 0.081 ENSMUST00000069537.2
ENSMUST00000178385.1
 Zfand6

zinc finger, AN1-type domain 6

chrX_-_140956675 0.054 ENSMUST00000033805.8
ENSMUST00000112978.1
 Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr14_-_47418407 0.052 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr11_+_70026815 0.051 ENSMUST00000135916.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr19_-_5457397 0.049 ENSMUST00000179549.1
 Ccdc85b
coiled-coil domain containing 85B
chr17_-_51832666 0.045 ENSMUST00000144331.1
 Satb1
special AT-rich sequence binding protein 1
chr17_+_84956718 0.044 ENSMUST00000112305.3
 Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
chr12_-_91746020 0.038 ENSMUST00000166967.1
 Ston2
stonin 2
chr11_+_110968056 0.037 ENSMUST00000125692.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_+_82867327 0.036 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr10_+_20347788 0.032 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr3_+_121291725 0.031 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr1_-_63114516 0.022 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr15_+_21111452 0.008 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr1_+_34439851 0.007 ENSMUST00000027303.7
 Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr17_+_70522083 0.004 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0072092 ureteric bud invasion(GO:0072092)
0.5 3.7 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.3 0.9 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 1.7 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.2 0.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.5 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.3 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.2 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.3 GO:0051182 coenzyme transport(GO:0051182)
0.0 1.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.8 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.6 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.8 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 1.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.5 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.4 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.4 GO:1904872 regulation of telomerase RNA localization to Cajal body(GO:1904872) positive regulation of telomerase RNA localization to Cajal body(GO:1904874)
0.0 0.1 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.4 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.5 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0044299 C-fiber(GO:0044299)
0.1 0.8 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 5.7 GO:0005871 kinesin complex(GO:0005871)
0.1 0.3 GO:0097513 myosin II filament(GO:0097513)
0.1 3.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0032009 early phagosome(GO:0032009)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 5.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 0.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.8 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.5 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)