Motif ID: Nkx2-4

Z-value: 0.804


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.303.0e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Showing 1 to 20 of 80 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_178798438 5.653 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr4_-_136892867 3.653 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr13_-_66852017 1.874 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr15_+_99055164 1.836 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr3_+_52268337 1.687 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr2_+_169633517 1.191 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr2_+_169632996 1.188 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr15_-_26895049 1.025 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr10_-_26373956 0.929 ENSMUST00000105519.3
ENSMUST00000040219.6
 L3mbtl3

l(3)mbt-like 3 (Drosophila)

chr12_+_38781093 0.878 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr3_-_59220150 0.874 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr13_+_65512678 0.843 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr13_-_105271039 0.842 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr2_+_140170641 0.811 ENSMUST00000044825.4
 Ndufaf5
NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
chr9_-_71896047 0.752 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr5_+_89027959 0.702 ENSMUST00000130041.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr12_+_38780817 0.682 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr2_-_147186389 0.580 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr5_+_89028035 0.516 ENSMUST00000113216.2
ENSMUST00000134303.1
 Slc4a4

solute carrier family 4 (anion exchanger), member 4

chr8_+_31091593 0.469 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.7 GO:0072092 ureteric bud invasion(GO:0072092)
0.5 3.7 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 1.8 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.2 1.7 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.0 1.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 1.2 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.3 0.9 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.8 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 0.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.6 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.2 0.5 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.5 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.5 GO:0097320 membrane tubulation(GO:0097320)
0.1 0.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.4 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.4 GO:1904872 regulation of telomerase RNA localization to Cajal body(GO:1904872) positive regulation of telomerase RNA localization to Cajal body(GO:1904874)
0.0 0.4 GO:0071625 vocalization behavior(GO:0071625)
0.1 0.3 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0005871 kinesin complex(GO:0005871)
0.1 3.7 GO:0005581 collagen trimer(GO:0005581)
0.6 1.8 GO:0044299 C-fiber(GO:0044299)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.8 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.1 0.3 GO:0097513 myosin II filament(GO:0097513)
0.0 0.3 GO:0032009 early phagosome(GO:0032009)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.4 1.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.8 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 0.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.5 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)