Motif ID: Mecp2

Z-value: 1.059


Transcription factors associated with Mecp2:

Gene SymbolEntrez IDGene Name
Mecp2 ENSMUSG00000031393.10 Mecp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecp2mm10_v2_chrX_-_74085656_740856900.563.8e-02Click!


Activity profile for motif Mecp2.

activity profile for motif Mecp2


Sorted Z-values histogram for motif Mecp2

Sorted Z-values for motif Mecp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 2.077 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr11_-_63922257 2.031 ENSMUST00000094103.3
 Hs3st3b1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr12_-_108003414 1.925 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr4_-_142239356 1.690 ENSMUST00000036476.3
 Kazn
kazrin, periplakin interacting protein
chr11_+_7063423 1.508 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr16_-_22161450 1.499 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr11_-_4746778 1.455 ENSMUST00000009219.2
 Cabp7
calcium binding protein 7
chr11_-_7213897 1.440 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr17_-_87797994 1.432 ENSMUST00000055221.7
 Kcnk12
potassium channel, subfamily K, member 12
chr15_-_93595877 1.367 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr13_-_56252163 1.325 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr2_+_52857844 1.272 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr12_-_108003594 1.250 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr7_+_121392266 1.236 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr12_-_81333129 1.175 ENSMUST00000085238.6
ENSMUST00000182208.1
 Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr7_-_120982260 1.059 ENSMUST00000033169.8
 Cdr2
cerebellar degeneration-related 2
chr17_-_83631892 1.012 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr14_-_102982630 1.007 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr10_+_100015817 0.998 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr1_-_106714217 0.973 ENSMUST00000112751.1
 Bcl2
B cell leukemia/lymphoma 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 839 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.5 3.1 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.0 2.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.7 2.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.3 2.2 GO:0006477 protein sulfation(GO:0006477)
0.1 2.0 GO:0060749 mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377)
0.4 1.8 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.1 1.8 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.5 1.6 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 1.6 GO:0001842 neural fold formation(GO:0001842)
0.0 1.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 1.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.1 1.5 GO:0007020 microtubule nucleation(GO:0007020)
0.1 1.5 GO:0060074 synapse maturation(GO:0060074)
0.0 1.5 GO:0016601 Rac protein signal transduction(GO:0016601)
0.5 1.4 GO:1990034 calcium ion export from cell(GO:1990034)
0.2 1.4 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.2 1.4 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.2 1.4 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 264 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 3.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.2 GO:0016605 PML body(GO:0016605)
0.1 1.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.9 GO:0031965 nuclear membrane(GO:0031965)
0.1 1.7 GO:0035253 ciliary rootlet(GO:0035253)
0.1 1.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.6 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.6 GO:0030673 axolemma(GO:0030673)
0.1 1.5 GO:0071565 nBAF complex(GO:0071565)
0.0 1.5 GO:0031968 organelle outer membrane(GO:0031968)
0.4 1.4 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.3 1.4 GO:0001533 cornified envelope(GO:0001533)
0.2 1.2 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.1 1.2 GO:0043196 varicosity(GO:0043196)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.1 1.1 GO:1904115 axon cytoplasm(GO:1904115)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 435 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 3.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 2.9 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 2.6 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.4 2.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.2 2.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 2.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 2.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 1.8 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 1.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.7 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 1.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.6 GO:0019905 syntaxin binding(GO:0019905)
0.3 1.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2 1.5 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)