Motif ID: Lhx2_Hoxc5

Z-value: 1.252

Transcription factors associated with Lhx2_Hoxc5:

Gene SymbolEntrez IDGene Name
Hoxc5 ENSMUSG00000022485.3 Hoxc5
Lhx2 ENSMUSG00000000247.5 Lhx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx2mm10_v2_chr2_+_38339258_383392810.732.7e-03Click!


Activity profile for motif Lhx2_Hoxc5.

activity profile for motif Lhx2_Hoxc5


Sorted Z-values histogram for motif Lhx2_Hoxc5

Sorted Z-values for motif Lhx2_Hoxc5



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx2_Hoxc5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_170009892 4.388 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr19_-_11604828 3.766 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr17_+_17316078 3.068 ENSMUST00000105311.3
 Gm6712
predicted gene 6712
chr5_-_43981757 2.982 ENSMUST00000061299.7
 Fgfbp1
fibroblast growth factor binding protein 1
chrM_+_10167 2.850 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chrY_+_90785442 2.759 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chr5_-_106926245 2.721 ENSMUST00000117588.1
 Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr19_-_32196393 2.694 ENSMUST00000151822.1
 Sgms1
sphingomyelin synthase 1
chr6_+_116650674 2.605 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr2_-_180954620 2.487 ENSMUST00000139929.1
 Nkain4
Na+/K+ transporting ATPase interacting 4
chr12_+_16653470 2.375 ENSMUST00000111064.1
 Ntsr2
neurotensin receptor 2
chr10_-_8886033 2.314 ENSMUST00000015449.5
 Sash1
SAM and SH3 domain containing 1
chrM_+_11734 2.294 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr19_+_11518493 2.276 ENSMUST00000025580.3
 Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr7_-_45103747 2.221 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr1_-_24612700 2.212 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr8_+_66386292 2.153 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chrX_-_134111852 2.141 ENSMUST00000033610.6
 Nox1
NADPH oxidase 1
chr8_-_4779513 2.039 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chrX_+_170010744 2.022 ENSMUST00000178789.1
 Gm21887
predicted gene, 21887

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 3.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4 3.0 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.6 2.8 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 2.8 GO:0022900 electron transport chain(GO:0022900)
0.3 2.7 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 2.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.5 2.6 GO:0030091 protein repair(GO:0030091)
0.4 2.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.8 2.3 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 2.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 2.3 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 2.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 2.2 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.5 2.1 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.7 2.0 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.3 2.0 GO:0016584 nucleosome positioning(GO:0016584)
0.6 1.9 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 1.9 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.6 1.8 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.1 GO:0070469 respiratory chain(GO:0070469)
0.0 3.7 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.1 3.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 2.7 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 2.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.5 2.1 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.1 1.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.7 GO:0031513 nonmotile primary cilium(GO:0031513)
0.3 1.6 GO:0044301 climbing fiber(GO:0044301)
0.2 1.6 GO:0001739 sex chromatin(GO:0001739)
0.1 1.6 GO:0005922 connexon complex(GO:0005922)
0.3 1.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 1.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 13.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 4.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.8 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.1 3.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.0 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 2.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.7 2.7 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.3 2.6 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 2.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.5 GO:0004386 helicase activity(GO:0004386)
0.1 2.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 2.3 GO:0042169 SH2 domain binding(GO:0042169)
0.7 2.2 GO:0019770 IgG receptor activity(GO:0019770)
0.1 2.2 GO:0042287 MHC protein binding(GO:0042287)
0.7 2.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.3 2.0 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.2 1.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 1.8 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 1.7 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 1.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)