Motif ID: Snai1_Zeb1_Snai2

Z-value: 1.566

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5593566_55936020.723.8e-03Click!
Snai1mm10_v2_chr2_+_167538192_1675382100.525.9e-02Click!
Snai2mm10_v2_chr16_+_14705832_147058580.293.2e-01Click!


Activity profile for motif Snai1_Zeb1_Snai2.

activity profile for motif Snai1_Zeb1_Snai2


Sorted Z-values histogram for motif Snai1_Zeb1_Snai2

Sorted Z-values for motif Snai1_Zeb1_Snai2



Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_114131229 8.365 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr16_+_91269759 5.023 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr4_-_136892867 3.933 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr7_-_29281977 3.712 ENSMUST00000098604.4
ENSMUST00000108236.3
 Spint2

serine protease inhibitor, Kunitz type 2

chr11_-_101785252 3.442 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr4_-_136898803 3.380 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr2_-_114013619 3.301 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr4_-_64046925 3.117 ENSMUST00000107377.3
 Tnc
tenascin C
chr12_-_76709997 3.005 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr8_+_70493156 2.907 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr17_-_26201363 2.819 ENSMUST00000121959.1
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr15_+_54571358 2.662 ENSMUST00000025356.2
 Mal2
mal, T cell differentiation protein 2
chr13_-_37049203 2.644 ENSMUST00000037491.8
 F13a1
coagulation factor XIII, A1 subunit
chr7_+_35119285 2.610 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr1_+_91179822 2.558 ENSMUST00000097648.4
ENSMUST00000165855.1
 Ramp1

receptor (calcitonin) activity modifying protein 1

chr15_-_54919961 2.517 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr5_+_75075464 2.331 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr18_+_5591860 2.320 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr12_+_85473883 2.254 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr7_-_4789541 2.239 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 837 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.5 5.4 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.7 4.4 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.6 4.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.5 4.3 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.4 4.3 GO:0071635 negative regulation of transforming growth factor beta production(GO:0071635)
0.6 4.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.6 4.1 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.3 4.0 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.6 3.6 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.1 3.6 GO:0009648 photoperiodism(GO:0009648)
1.2 3.5 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.6 3.5 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.3 3.5 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.4 3.4 GO:1903596 regulation of gap junction assembly(GO:1903596)
0.2 3.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 3.4 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.4 3.3 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.3 3.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.8 3.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 291 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.0 GO:0005667 transcription factor complex(GO:0005667)
0.2 10.9 GO:0005581 collagen trimer(GO:0005581)
0.0 7.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.3 5.7 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.4 5.3 GO:0005922 connexon complex(GO:0005922)
0.1 4.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 4.6 GO:0005840 ribosome(GO:0005840)
1.4 4.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 3.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 3.9 GO:0031941 filamentous actin(GO:0031941)
0.2 3.7 GO:0005605 basal lamina(GO:0005605)
0.7 3.6 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
1.2 3.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 3.5 GO:0002080 acrosomal membrane(GO:0002080)
0.1 3.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.8 3.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.3 3.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.0 2.9 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.9 2.8 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.3 2.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 485 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.0 GO:0003924 GTPase activity(GO:0003924)
3.0 9.0 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 7.0 GO:0005080 protein kinase C binding(GO:0005080)
0.8 5.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 5.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 5.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.5 GO:0070888 E-box binding(GO:0070888)
0.1 4.5 GO:0005178 integrin binding(GO:0005178)
0.1 4.4 GO:0071837 HMG box domain binding(GO:0071837)
0.6 4.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 4.3 GO:0005179 hormone activity(GO:0005179)
0.4 4.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 4.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.0 3.9 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 3.8 GO:0005112 Notch binding(GO:0005112)
0.2 3.6 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
1.2 3.5 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 3.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 3.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 3.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)