Motif ID: Wrnip1_Mta3_Rcor1

Z-value: 2.877

Transcription factors associated with Wrnip1_Mta3_Rcor1:

Gene SymbolEntrez IDGene Name
Mta3 ENSMUSG00000055817.11 Mta3
Rcor1 ENSMUSG00000037896.11 Rcor1
Wrnip1 ENSMUSG00000021400.6 Wrnip1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rcor1mm10_v2_chr12_+_111039334_111039400-0.876.2e-05Click!
Mta3mm10_v2_chr17_+_83706137_83706169-0.312.8e-01Click!
Wrnip1mm10_v2_chr13_+_32802007_328021520.283.4e-01Click!


Activity profile for motif Wrnip1_Mta3_Rcor1.

activity profile for motif Wrnip1_Mta3_Rcor1


Sorted Z-values histogram for motif Wrnip1_Mta3_Rcor1

Sorted Z-values for motif Wrnip1_Mta3_Rcor1



Network of associatons between targets according to the STRING database.



First level regulatory network of Wrnip1_Mta3_Rcor1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_34372004 6.017 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chr1_+_42697146 5.909 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3
chr7_-_19699008 5.285 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr2_+_71529085 4.315 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr2_-_25470031 4.244 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr5_+_90772435 4.071 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr18_+_65873478 3.880 ENSMUST00000025395.8
ENSMUST00000173530.1
 Grp

gastrin releasing peptide

chr8_+_12395287 3.837 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr2_-_71546745 3.774 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr16_-_10785525 3.621 ENSMUST00000038099.4
 Socs1
suppressor of cytokine signaling 1
chr7_-_45103747 3.512 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chrX_+_73483602 3.481 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr7_+_30413744 3.474 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr4_-_139092958 3.438 ENSMUST00000042844.6
 Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr10_+_79716588 3.406 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr16_+_91269759 3.367 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr4_-_136892867 3.324 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr4_+_148160613 3.293 ENSMUST00000047951.8
 Fbxo2
F-box protein 2
chr7_-_142657466 3.287 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr16_+_92498122 3.233 ENSMUST00000023670.3
 Clic6
chloride intracellular channel 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,319 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.9 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.6 12.7 GO:0021516 dorsal spinal cord development(GO:0021516)
0.3 11.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.6 10.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.7 9.7 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
3.1 9.3 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
2.9 8.8 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
1.4 8.2 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.2 8.2 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.9 8.0 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
1.6 7.9 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 7.8 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.2 7.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 7.2 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.3 7.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 7.1 GO:0006412 translation(GO:0006412)
0.9 6.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.6 6.2 GO:0072235 distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.8 6.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 6.2 GO:0000387 spliceosomal snRNP assembly(GO:0000387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 424 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 104.4 GO:0005615 extracellular space(GO:0005615)
0.0 97.1 GO:0005576 extracellular region(GO:0005576)
0.1 37.6 GO:0005667 transcription factor complex(GO:0005667)
0.4 32.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 28.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 21.1 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.3 19.0 GO:0005581 collagen trimer(GO:0005581)
0.1 17.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 15.5 GO:0072562 blood microparticle(GO:0072562)
0.1 15.4 GO:0005924 cell-substrate adherens junction(GO:0005924)
0.0 12.1 GO:0005739 mitochondrion(GO:0005739)
0.1 11.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 11.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.4 9.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 9.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
2.9 8.8 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 8.3 GO:0044391 ribosomal subunit(GO:0044391)
0.6 7.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 6.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 6.4 GO:0031231 intrinsic component of peroxisomal membrane(GO:0031231)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 712 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 64.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 21.8 GO:0005080 protein kinase C binding(GO:0005080)
0.2 17.7 GO:0008083 growth factor activity(GO:0008083)
0.4 17.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.5 17.1 GO:0071837 HMG box domain binding(GO:0071837)
0.3 15.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.6 15.3 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 13.0 GO:0051015 actin filament binding(GO:0051015)
0.3 12.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 11.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 11.4 GO:0005178 integrin binding(GO:0005178)
0.3 9.9 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.3 9.5 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.2 9.4 GO:0005125 cytokine activity(GO:0005125)
0.3 9.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
2.9 8.8 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.6 7.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 7.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 7.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 7.5 GO:0019003 GDP binding(GO:0019003)