Motif ID: E2f8

Z-value: 1.251


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.723.5e-03Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 92 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_101785252 7.010 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr1_-_128359610 3.695 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr6_+_21215472 3.660 ENSMUST00000081542.5
 Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr11_+_26387194 2.900 ENSMUST00000109509.1
ENSMUST00000136830.1
 Fancl

Fanconi anemia, complementation group L

chr8_+_40926220 2.864 ENSMUST00000034004.9
 Pdgfrl
platelet-derived growth factor receptor-like
chr2_-_155945282 2.678 ENSMUST00000040162.2
 Gdf5
growth differentiation factor 5
chr10_-_21160925 2.613 ENSMUST00000020158.6
 Myb
myeloblastosis oncogene
chr16_-_46496955 2.223 ENSMUST00000023335.6
ENSMUST00000023334.8
 Pvrl3

poliovirus receptor-related 3

chr11_-_89302545 2.125 ENSMUST00000061728.3
 Nog
noggin
chr16_-_46496772 2.057 ENSMUST00000149901.1
ENSMUST00000096052.2
 Pvrl3

poliovirus receptor-related 3

chr8_+_75109528 1.922 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr15_-_76090013 1.850 ENSMUST00000019516.4
 Nrbp2
nuclear receptor binding protein 2
chr2_-_34913976 1.779 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr2_+_145785980 1.721 ENSMUST00000110005.1
ENSMUST00000094480.4
 Rin2

Ras and Rab interactor 2

chr5_+_137787769 1.639 ENSMUST00000035852.7
 Zcwpw1
zinc finger, CW type with PWWP domain 1
chr4_+_132768325 1.163 ENSMUST00000102561.4
 Rpa2
replication protein A2
chr9_+_100643605 1.097 ENSMUST00000041418.6
 Stag1
stromal antigen 1
chr16_-_18811615 1.092 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr9_-_36726374 1.088 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr16_+_20733104 1.051 ENSMUST00000115423.1
ENSMUST00000007171.6
 Chrd

chordin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.2 3.7 GO:0045475 locomotor rhythm(GO:0045475)
0.0 2.9 GO:0006513 protein monoubiquitination(GO:0006513)
0.5 2.7 GO:0060591 chondroblast differentiation(GO:0060591)
0.2 2.6 GO:0045624 positive regulation of T-helper cell differentiation(GO:0045624)
0.2 2.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 2.4 GO:0006270 DNA replication initiation(GO:0006270)
0.5 2.1 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.7 2.0 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.4 1.9 GO:0002121 inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236)
0.0 1.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.3 1.8 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.5 1.4 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.2 1.4 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 1.2 GO:0030578 PML body organization(GO:0030578)
0.1 1.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.4 1.1 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 1.1 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.2 0.9 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 0.8 GO:0006290 pyrimidine dimer repair(GO:0006290)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.3 GO:0042555 MCM complex(GO:0042555)
0.1 3.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 2.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.9 GO:0032590 dendrite membrane(GO:0032590)
0.3 1.4 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 1.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.2 GO:0001741 XY body(GO:0001741)
0.4 1.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.3 1.0 GO:1990423 RZZ complex(GO:1990423)
0.0 1.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.2 0.8 GO:0031523 Myb complex(GO:0031523)
0.1 0.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.7 GO:0071004 U2-type prespliceosome(GO:0071004)
0.2 0.6 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.6 GO:0030894 replisome(GO:0030894)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.3 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.3 GO:1904115 axon cytoplasm(GO:1904115)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.7 3.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 3.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.4 2.7 GO:0036122 BMP binding(GO:0036122)
0.0 2.7 GO:0019955 cytokine binding(GO:0019955)
0.7 2.6 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 2.6 GO:0035064 methylated histone binding(GO:0035064)
0.3 2.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 1.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 1.2 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.4 1.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.2 1.1 GO:0045545 syndecan binding(GO:0045545)
0.2 0.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 0.7 GO:0005534 galactose binding(GO:0005534)
0.1 0.6 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.1 0.6 GO:0070087 chromo shadow domain binding(GO:0070087)