Motif ID: Pax8

Z-value: 0.960


Transcription factors associated with Pax8:

Gene SymbolEntrez IDGene Name
Pax8 ENSMUSG00000026976.9 Pax8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax8mm10_v2_chr2_-_24475097_24475215-0.117.0e-01Click!


Activity profile for motif Pax8.

activity profile for motif Pax8


Sorted Z-values histogram for motif Pax8

Sorted Z-values for motif Pax8



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_66860458 7.835 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr7_-_42578588 4.485 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr4_+_103313806 2.741 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr1_+_6487231 2.040 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr13_-_62607499 1.788 ENSMUST00000091563.4
 6720489N17Rik
RIKEN cDNA 6720489N17 gene
chrX_-_105391770 1.167 ENSMUST00000136406.1
ENSMUST00000150604.1
 5330434G04Rik

RIKEN cDNA 5330434G04 gene

chr13_-_25270076 0.970 ENSMUST00000057866.6
 Nrsn1
neurensin 1
chr11_-_69801716 0.934 ENSMUST00000011285.4
ENSMUST00000102585.1
 Fgf11

fibroblast growth factor 11

chr7_-_42706369 0.932 ENSMUST00000180131.1
 Gm17067
predicted gene 17067
chr16_-_17125106 0.908 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr9_+_109052828 0.811 ENSMUST00000124432.1
 Shisa5
shisa homolog 5 (Xenopus laevis)
chrX_-_105391726 0.800 ENSMUST00000142109.1
 5330434G04Rik
RIKEN cDNA 5330434G04 gene
chr7_+_6961160 0.774 ENSMUST00000054055.6
 Usp29
ubiquitin specific peptidase 29
chr4_+_6191093 0.695 ENSMUST00000029907.5
 Ubxn2b
UBX domain protein 2B
chr1_+_65186727 0.582 ENSMUST00000097707.4
ENSMUST00000081154.7
 Pikfyve

phosphoinositide kinase, FYVE finger containing

chr5_+_100196611 0.505 ENSMUST00000066813.1
 Gm9932
predicted gene 9932
chr17_+_21691860 0.493 ENSMUST00000072133.4
 Gm10226
predicted gene 10226
chr4_+_156215920 0.456 ENSMUST00000105572.1
 2310042D19Rik
RIKEN cDNA 2310042D19 gene
chr13_-_62520451 0.450 ENSMUST00000082203.6
ENSMUST00000101547.4
 Zfp934

zinc finger protein 934

chr7_+_112742025 0.430 ENSMUST00000164363.1
 Tead1
TEA domain family member 1
chr18_-_12121460 0.393 ENSMUST00000055447.6
ENSMUST00000050228.7
ENSMUST00000092075.4
 Tmem241


transmembrane protein 241


chr7_-_78783026 0.385 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr3_+_135212557 0.375 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr12_+_71048338 0.367 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr7_-_29906087 0.341 ENSMUST00000053521.8
 Zfp27
zinc finger protein 27
chr9_+_32116040 0.323 ENSMUST00000174641.1
 Arhgap32
Rho GTPase activating protein 32
chr1_+_64690443 0.289 ENSMUST00000114077.1
 Ccnyl1
cyclin Y-like 1
chr2_+_128967383 0.150 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr17_+_45555693 0.132 ENSMUST00000024742.7
 Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
chrX_+_82948861 0.131 ENSMUST00000114000.1
 Dmd
dystrophin, muscular dystrophy
chr2_+_143915273 0.080 ENSMUST00000103172.3
 Dstn
destrin
chr9_-_103230415 0.060 ENSMUST00000035158.9
 Trf
transferrin
chr9_-_103230262 0.058 ENSMUST00000165296.1
ENSMUST00000112645.1
ENSMUST00000166836.1
 Trf

Gm20425
transferrin

predicted gene 20425
chr10_+_82378593 0.029 ENSMUST00000165906.1
 Gm4924
predicted gene 4924
chr13_-_62777089 0.019 ENSMUST00000167516.2
 Gm5141
predicted gene 5141

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 10.6 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.1 0.4 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 0.4 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.7 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.1 GO:0008065 establishment of blood-nerve barrier(GO:0008065) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.4 GO:0014883 transition between fast and slow fiber(GO:0014883) positive regulation of stem cell population maintenance(GO:1902459)
0.0 0.6 GO:0032288 myelin assembly(GO:0032288)
0.0 0.1 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.0 0.1 GO:0042940 D-amino acid transport(GO:0042940)
0.0 0.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.4 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778) mitotic spindle midzone(GO:1990023)
0.0 0.1 GO:0097433 dense body(GO:0097433)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.8 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.6 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)