Motif ID: Aire

Z-value: 0.771


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 103 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 19.725 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr13_-_110280103 3.547 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr12_-_78983476 3.331 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr3_-_116968969 3.242 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr16_+_36875119 3.134 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
 Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr19_-_28963863 2.624 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr14_+_76476913 2.393 ENSMUST00000140251.2
 Tsc22d1
TSC22 domain family, member 1
chr10_-_130280218 2.202 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr8_+_69808672 2.190 ENSMUST00000036074.8
ENSMUST00000123453.1
 Gmip

Gem-interacting protein

chr18_+_37400845 2.070 ENSMUST00000057228.1
 Pcdhb9
protocadherin beta 9
chr9_-_97111117 1.678 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr7_-_127895578 1.669 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr2_-_134644079 1.640 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4
chr8_+_64947177 1.577 ENSMUST00000079896.7
ENSMUST00000026595.5
 Tmem192

transmembrane protein 192

chr5_-_84417359 1.518 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr18_+_37725706 1.502 ENSMUST00000066149.6
 Pcdhga9
protocadherin gamma subfamily A, 9
chr10_+_86021961 1.374 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr8_-_4217133 1.264 ENSMUST00000175906.1
 BC068157
cDNA sequence BC068157
chr5_+_43672289 1.216 ENSMUST00000156034.1
 Cc2d2a
coiled-coil and C2 domain containing 2A
chr10_-_81014902 1.205 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
 Gng7


guanine nucleotide binding protein (G protein), gamma 7



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 3.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 2.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 2.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 2.1 GO:0007416 synapse assembly(GO:0007416)
0.0 1.8 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.6 1.7 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.4 1.7 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.2 1.5 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 1.4 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.2 1.2 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 1.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 1.2 GO:0032288 myelin assembly(GO:0032288)
0.3 1.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 1.1 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.2 1.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 1.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 1.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 1.0 GO:0008589 regulation of smoothened signaling pathway(GO:0008589)
0.3 0.9 GO:0006550 isoleucine catabolic process(GO:0006550) acetyl-CoA catabolic process(GO:0046356) ketone body catabolic process(GO:0046952)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.2 GO:0043197 dendritic spine(GO:0043197)
0.1 3.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 1.4 GO:1990037 Lewy body core(GO:1990037)
0.1 1.2 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.2 GO:0036038 MKS complex(GO:0036038)
0.1 1.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 0.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.8 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1 0.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.4 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0031489 myosin V binding(GO:0031489)
0.1 2.9 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.7 GO:0048038 quinone binding(GO:0048038)
0.1 1.7 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 1.6 GO:0070566 adenylyltransferase activity(GO:0070566)
0.2 1.5 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 1.4 GO:0043130 ubiquitin binding(GO:0043130)
0.1 1.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 1.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.2 1.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 1.1 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 0.9 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.2 0.9 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1 0.9 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.8 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.1 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 0.4 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 1.7 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.9 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 0.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol