Motif ID: Alx4

Z-value: 0.567


Transcription factors associated with Alx4:

Gene SymbolEntrez IDGene Name
Alx4 ENSMUSG00000040310.6 Alx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx4mm10_v2_chr2_+_93642307_93642388-0.143.9e-01Click!


Activity profile for motif Alx4.

activity profile for motif Alx4


Sorted Z-values histogram for motif Alx4

Sorted Z-values for motif Alx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Alx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_97479470 2.618 ENSMUST00000105287.3
 Dcn
decorin
chr6_-_136875794 1.930 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr13_-_81710937 1.791 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr13_+_44121167 1.750 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chrM_+_2743 1.689 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr15_+_9436028 1.597 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr7_-_45103747 1.586 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chrM_+_9452 1.547 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chrX_-_134111852 1.512 ENSMUST00000033610.6
 Nox1
NADPH oxidase 1
chr1_-_163725123 1.451 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr8_+_23411490 1.357 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chr7_-_46667375 1.349 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chrX_+_73483602 1.338 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr2_+_91257323 1.287 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr19_+_55895508 1.271 ENSMUST00000111646.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chrM_+_10167 1.202 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr8_+_94152607 1.170 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr10_-_37138863 1.106 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr1_-_152386675 1.084 ENSMUST00000015124.8
 Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
chr2_-_160619971 1.072 ENSMUST00000109473.1
 Gm14221
predicted gene 14221

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.7 2.7 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 2.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 2.3 GO:0022904 respiratory electron transport chain(GO:0022904)
0.3 2.1 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 2.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.2 2.0 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.0 1.9 GO:0030500 regulation of bone mineralization(GO:0030500)
0.1 1.8 GO:0033194 response to hydroperoxide(GO:0033194)
0.1 1.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.5 GO:0051923 sulfation(GO:0051923)
0.5 1.4 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.2 1.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 1.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.3 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.1 1.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3 1.0 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.0 1.0 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 1.0 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.9 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0070469 respiratory chain(GO:0070469)
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 2.6 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 2.6 GO:0005802 trans-Golgi network(GO:0005802)
0.5 2.1 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 1.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 1.5 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 1.1 GO:0042585 germinal vesicle(GO:0042585)
0.1 1.0 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.6 GO:0097422 tubular endosome(GO:0097422)
0.0 0.6 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.5 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 0.5 GO:0070820 tertiary granule(GO:0070820)
0.1 0.5 GO:0005687 U4 snRNP(GO:0005687)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.7 2.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.4 2.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 2.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 2.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 1.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 1.6 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 1.5 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.5 1.5 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 1.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 1.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.3 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 1.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.2 1.2 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 1.1 GO:0005080 protein kinase C binding(GO:0005080)
0.2 1.0 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 1.0 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.9 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.9 PID_P73PATHWAY p73 transcription factor network
0.0 0.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.6 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.4 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 2.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 1.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.1 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.0 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.0 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 0.8 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.4 REACTOME_POL_SWITCHING Genes involved in Polymerase switching