Motif ID: Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.742

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec:

Gene SymbolEntrez IDGene Name
Arntl ENSMUSG00000055116.7 Arntl
Mitf ENSMUSG00000035158.9 Mitf
Mlx ENSMUSG00000017801.9 Mlx
Mlxipl ENSMUSG00000005373.7 Mlxipl
Tfe3 ENSMUSG00000000134.11 Tfe3
Tfec ENSMUSG00000029553.7 Tfec

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Arntlmm10_v2_chr7_+_113207465_113207595-0.453.2e-03Click!
Mlxmm10_v2_chr11_+_101087277_101087323-0.333.8e-02Click!
Tfe3mm10_v2_chrX_+_7762652_7762695-0.305.9e-02Click!
Mitfmm10_v2_chr6_+_97807014_97807067-0.153.4e-01Click!
Mlxiplmm10_v2_chr5_+_135106881_135106918-0.038.6e-01Click!


Activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec.

activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec


Sorted Z-values histogram for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Sorted Z-values for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec



Network of associatons between targets according to the STRING database.



First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_108660616 6.987 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr19_-_4201591 6.724 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr10_+_127063599 6.020 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr10_+_127063527 5.377 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr6_+_108660772 5.062 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr3_+_137864573 4.760 ENSMUST00000174561.1
ENSMUST00000173790.1
 H2afz

H2A histone family, member Z

chr5_-_137314175 4.270 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr11_-_94653964 4.048 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr5_+_99979061 4.028 ENSMUST00000046721.1
 4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr11_+_70000578 3.892 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr2_+_121449362 3.889 ENSMUST00000110615.1
ENSMUST00000099475.5
 Serf2

small EDRK-rich factor 2

chr3_+_137864487 3.887 ENSMUST00000041045.7
 H2afz
H2A histone family, member Z
chr7_-_45466894 3.726 ENSMUST00000033093.8
 Bax
BCL2-associated X protein
chr19_-_10203880 3.647 ENSMUST00000142241.1
ENSMUST00000116542.2
ENSMUST00000025651.5
ENSMUST00000156291.1
 Fen1



flap structure specific endonuclease 1



chr10_-_128923948 3.558 ENSMUST00000131271.1
 Bloc1s1
biogenesis of lysosome-related organelles complex-1, subunit 1
chrY_-_1245685 3.163 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr17_-_12769605 3.093 ENSMUST00000024599.7
 Igf2r
insulin-like growth factor 2 receptor
chr3_+_90052814 3.087 ENSMUST00000160640.1
ENSMUST00000029552.6
ENSMUST00000162114.1
ENSMUST00000068798.6
 4933434E20Rik



RIKEN cDNA 4933434E20 gene



chr17_+_56040350 3.057 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr2_-_71546745 3.049 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 549 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 11.4 GO:0010288 response to lead ion(GO:0010288)
0.4 10.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.8 8.9 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.4 8.6 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.2 7.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 6.9 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.9 5.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.8 5.0 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.1 5.0 GO:0048255 mRNA stabilization(GO:0048255)
0.6 4.9 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 4.4 GO:0032526 response to retinoic acid(GO:0032526)
0.8 4.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
1.3 4.0 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 4.0 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.8 3.9 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.9 3.6 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 3.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.6 3.2 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
1.0 3.0 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.4 3.0 GO:0021847 ventricular zone neuroblast division(GO:0021847)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 237 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.7 GO:0016604 nuclear body(GO:0016604)
0.1 12.3 GO:0022626 cytosolic ribosome(GO:0022626)
2.8 11.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
1.2 8.5 GO:0001740 Barr body(GO:0001740)
1.1 6.7 GO:0030896 checkpoint clamp complex(GO:0030896)
0.4 6.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 5.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.6 4.9 GO:0033186 CAF-1 complex(GO:0033186)
0.0 4.8 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.1 4.7 GO:0031519 PcG protein complex(GO:0031519)
0.8 4.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 4.1 GO:0030914 STAGA complex(GO:0030914)
0.1 4.1 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 4.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.4 4.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 3.6 GO:0016235 aggresome(GO:0016235)
0.1 3.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 3.5 GO:0031012 extracellular matrix(GO:0031012)
0.1 3.3 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 334 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
2.0 12.0 GO:0043426 MRF binding(GO:0043426)
0.1 11.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 11.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 7.2 GO:0003727 single-stranded RNA binding(GO:0003727)
1.7 6.7 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 5.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 5.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.7 4.9 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 4.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 4.6 GO:0050699 WW domain binding(GO:0050699)
0.0 4.6 GO:0003924 GTPase activity(GO:0003924)
0.3 4.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.7 4.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 3.9 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 3.9 GO:0005109 frizzled binding(GO:0005109)
0.5 3.7 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.4 3.7 GO:0051434 BH3 domain binding(GO:0051434)
0.1 3.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 3.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 12.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6 10.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 9.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 8.3 PID_ATR_PATHWAY ATR signaling pathway
0.1 7.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 7.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 5.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 5.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 5.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 5.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 4.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 4.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 2.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 2.4 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 2.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 14.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 11.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 9.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 8.6 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.1 8.3 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.1 8.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 7.7 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 6.4 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.1 5.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.3 5.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 5.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 5.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.4 4.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.3 4.4 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.1 3.7 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 3.1 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 3.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 3.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)