Motif ID: Ascl2

Z-value: 0.667


Transcription factors associated with Ascl2:

Gene SymbolEntrez IDGene Name
Ascl2 ENSMUSG00000009248.5 Ascl2



Activity profile for motif Ascl2.

activity profile for motif Ascl2


Sorted Z-values histogram for motif Ascl2

Sorted Z-values for motif Ascl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ascl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_106458440 3.767 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr8_+_31091593 3.020 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr7_-_28302238 2.722 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr11_+_99864476 2.067 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chr12_-_40037387 1.922 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr3_+_123446913 1.893 ENSMUST00000029603.8
 Prss12
protease, serine, 12 neurotrypsin (motopsin)
chr1_-_84696182 1.800 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr8_+_105518736 1.724 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr12_-_40038025 1.644 ENSMUST00000101472.3
 Arl4a
ADP-ribosylation factor-like 4A
chr6_+_56017489 1.621 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr3_-_116253467 1.618 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr6_+_105677745 1.565 ENSMUST00000113261.2
ENSMUST00000113264.2
 Cntn4

contactin 4

chr3_-_17786834 1.519 ENSMUST00000099198.2
 Gm10742
predicted gene 10742
chr2_+_136052180 1.518 ENSMUST00000144403.1
 Lamp5
lysosomal-associated membrane protein family, member 5
chr7_-_141443314 1.432 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr7_+_142471838 1.415 ENSMUST00000038946.2
 Lsp1
lymphocyte specific 1
chr8_-_105471481 1.364 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr7_+_16875302 1.331 ENSMUST00000108493.1
 Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr13_-_98206151 1.318 ENSMUST00000109426.1
 Arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr5_-_69341699 1.300 ENSMUST00000054095.4
 Kctd8
potassium channel tetramerisation domain containing 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0001709 cell fate determination(GO:0001709)
1.0 3.0 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 2.9 GO:0050873 brown fat cell differentiation(GO:0050873)
0.5 2.7 GO:0007386 compartment pattern specification(GO:0007386)
0.0 2.5 GO:0001764 neuron migration(GO:0001764)
0.1 1.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 1.8 GO:0007220 Notch receptor processing(GO:0007220)
0.1 1.7 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.4 1.6 GO:0061743 motor learning(GO:0061743)
0.1 1.6 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.2 1.5 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 1.5 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 1.5 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 1.4 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 1.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 1.2 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.2 1.2 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.2 1.2 GO:0089718 amino acid import across plasma membrane(GO:0089718) L-glutamate import across plasma membrane(GO:0098712)
0.1 1.2 GO:0046069 cGMP catabolic process(GO:0046069)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 2.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.9 GO:0043083 synaptic cleft(GO:0043083)
0.3 1.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 1.4 GO:0097427 microtubule bundle(GO:0097427)
0.3 1.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 1.1 GO:0043195 terminal bouton(GO:0043195)
0.0 1.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.3 0.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.9 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.2 0.6 GO:0005940 septin ring(GO:0005940)
0.1 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 GO:0003779 actin binding(GO:0003779)
0.0 4.8 GO:0003924 GTPase activity(GO:0003924)
1.0 3.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 2.4 GO:0005112 Notch binding(GO:0005112)
0.1 2.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 1.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 1.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.6 GO:0003774 motor activity(GO:0003774)
0.0 1.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.4 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.3 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.1 1.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 1.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.3 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.5 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 1.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 1.0 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 1.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.0 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases