Motif ID: Atf1_Creb5

Z-value: 0.753

Transcription factors associated with Atf1_Creb5:

Gene SymbolEntrez IDGene Name
Atf1 ENSMUSG00000023027.6 Atf1
Creb5 ENSMUSG00000053007.6 Creb5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb5mm10_v2_chr6_+_53573364_53573394-0.324.0e-02Click!
Atf1mm10_v2_chr15_+_100227871_100227878-0.278.5e-02Click!


Activity profile for motif Atf1_Creb5.

activity profile for motif Atf1_Creb5


Sorted Z-values histogram for motif Atf1_Creb5

Sorted Z-values for motif Atf1_Creb5



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf1_Creb5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_102490418 4.139 ENSMUST00000020040.3
 Nts
neurotensin
chr9_-_96752822 3.432 ENSMUST00000152594.1
 Zbtb38
zinc finger and BTB domain containing 38
chrX_-_21061981 3.112 ENSMUST00000040628.5
ENSMUST00000115333.2
ENSMUST00000115334.1
 Zfp182


zinc finger protein 182


chr7_+_130865756 2.446 ENSMUST00000120441.1
 Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr7_+_130865835 2.438 ENSMUST00000075181.4
ENSMUST00000048180.5
 Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chr12_+_102554966 2.359 ENSMUST00000021610.5
 Chga
chromogranin A
chr2_+_132781278 2.313 ENSMUST00000028826.3
 Chgb
chromogranin B
chr14_-_59597836 2.249 ENSMUST00000167100.1
ENSMUST00000022555.4
ENSMUST00000056997.7
ENSMUST00000171683.1
 Cdadc1



cytidine and dCMP deaminase domain containing 1



chr19_-_61228396 2.168 ENSMUST00000076046.6
 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr7_+_44496588 2.147 ENSMUST00000107927.3
 Fam71e1
family with sequence similarity 71, member E1
chr10_+_29211637 2.003 ENSMUST00000092627.4
 9330159F19Rik
RIKEN cDNA 9330159F19 gene
chrX_-_111697069 1.935 ENSMUST00000113422.2
ENSMUST00000038472.5
 Hdx

highly divergent homeobox

chr11_-_79254663 1.934 ENSMUST00000017821.5
 Wsb1
WD repeat and SOCS box-containing 1
chr6_-_39725448 1.876 ENSMUST00000002487.8
 Braf
Braf transforming gene
chr2_+_155276297 1.847 ENSMUST00000029128.3
 Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr7_-_126949499 1.842 ENSMUST00000106339.1
ENSMUST00000052937.5
 Asphd1

aspartate beta-hydroxylase domain containing 1

chr7_-_138846202 1.827 ENSMUST00000118810.1
ENSMUST00000075667.4
ENSMUST00000119664.1
 Mapk1ip1


mitogen-activated protein kinase 1 interacting protein 1


chr4_-_107810948 1.822 ENSMUST00000097930.1
 B230314M03Rik
RIKEN cDNA B230314M03 gene
chr3_+_145118564 1.757 ENSMUST00000098538.2
ENSMUST00000106192.2
ENSMUST00000029920.8
ENSMUST00000098539.2
 Odf2l



outer dense fiber of sperm tails 2-like



chr13_-_67484225 1.725 ENSMUST00000019572.7
 Zfp874b
zinc finger protein 874b

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.6 GO:0001553 luteinization(GO:0001553)
0.1 3.8 GO:0008542 visual learning(GO:0008542)
0.1 2.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.8 2.4 GO:1901079 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079)
0.3 2.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 2.2 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.1 1.7 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3 1.6 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.1 1.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 1.5 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.3 1.5 GO:0051012 microtubule sliding(GO:0051012)
0.2 1.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.2 1.5 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 1.5 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 1.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 1.5 GO:0009615 response to virus(GO:0009615)
0.2 1.4 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.0 1.4 GO:0007019 microtubule depolymerization(GO:0007019)
0.3 1.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.3 1.3 GO:0021764 amygdala development(GO:0021764)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0032587 ruffle membrane(GO:0032587)
0.5 2.4 GO:0042583 chromaffin granule(GO:0042583)
0.1 2.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.8 GO:0044754 autolysosome(GO:0044754)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 1.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.4 GO:0030141 secretory granule(GO:0030141)
0.2 1.3 GO:0033503 HULC complex(GO:0033503)
0.0 1.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.1 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.1 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 1.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.0 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 4.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 3.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 3.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.3 2.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 2.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.2 GO:0005125 cytokine activity(GO:0005125)
0.0 1.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.8 GO:0051213 dioxygenase activity(GO:0051213)
0.0 1.8 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 1.7 GO:0031489 myosin V binding(GO:0031489)
0.2 1.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 1.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 1.4 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 1.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.4 1.2 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.2 1.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 3.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.8 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.1 1.7 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.2 1.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.5 PID_ARF_3PATHWAY Arf1 pathway
0.1 1.2 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.2 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.2 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 2.2 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.7 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 1.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.1 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.0 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 0.7 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 0.7 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 0.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.7 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity