Motif ID: Atf3

Z-value: 0.835


Transcription factors associated with Atf3:

Gene SymbolEntrez IDGene Name
Atf3 ENSMUSG00000026628.8 Atf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf3mm10_v2_chr1_-_191183244_191183340-0.038.6e-01Click!


Activity profile for motif Atf3.

activity profile for motif Atf3


Sorted Z-values histogram for motif Atf3

Sorted Z-values for motif Atf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_84068766 1.928 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr7_-_137314394 1.614 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr6_-_137169710 1.525 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr11_+_113619318 1.510 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr7_-_38271310 1.246 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr15_-_78544345 1.236 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr1_+_55052770 1.168 ENSMUST00000027125.5
ENSMUST00000087617.4
 Coq10b

coenzyme Q10 homolog B (S. cerevisiae)

chr6_-_137169678 1.159 ENSMUST00000119610.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr11_-_84069179 1.132 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chr7_-_42578588 1.067 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr2_+_67748212 1.062 ENSMUST00000180887.1
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr15_-_91573181 1.061 ENSMUST00000109283.1
 Slc2a13
solute carrier family 2 (facilitated glucose transporter), member 13
chr12_+_102554966 1.013 ENSMUST00000021610.5
 Chga
chromogranin A
chr12_+_55598917 1.012 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr1_-_79440039 0.919 ENSMUST00000049972.4
 Scg2
secretogranin II
chr14_+_122475397 0.918 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr7_-_132317198 0.904 ENSMUST00000080215.5
 Chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr9_-_103222063 0.901 ENSMUST00000170904.1
 Trf
transferrin
chr14_+_13284774 0.850 ENSMUST00000070323.5
 Synpr
synaptoporin
chr5_-_92505518 0.841 ENSMUST00000031377.7
 Scarb2
scavenger receptor class B, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 523 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 2.0 GO:0030308 negative regulation of cell growth(GO:0030308)
0.4 1.7 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.2 1.7 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 1.6 GO:0010225 response to UV-C(GO:0010225)
0.1 1.5 GO:0060174 limb bud formation(GO:0060174)
0.5 1.4 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.1 1.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 1.3 GO:0048733 sebaceous gland development(GO:0048733)
0.1 1.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.4 1.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 1.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 1.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.1 1.1 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 1.1 GO:0030432 peristalsis(GO:0030432)
0.1 1.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 1.1 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 1.1 GO:0006623 protein targeting to vacuole(GO:0006623)
0.3 1.0 GO:1901079 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079)
0.1 1.0 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 1.7 GO:0097433 dense body(GO:0097433)
0.0 1.7 GO:0005776 autophagosome(GO:0005776)
0.0 1.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 1.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.5 GO:0060170 ciliary membrane(GO:0060170)
0.1 1.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 1.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.3 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.2 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.2 GO:0005770 late endosome(GO:0005770)
0.3 1.1 GO:0043202 lysosomal lumen(GO:0043202)
0.2 1.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 1.1 GO:0070187 telosome(GO:0070187)
0.1 1.1 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.1 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 307 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.9 2.7 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 2.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.0 GO:0044325 ion channel binding(GO:0044325)
0.1 1.9 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.9 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 1.7 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 1.7 GO:0005272 sodium channel activity(GO:0005272)
0.0 1.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 1.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 1.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.5 1.4 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
0.2 1.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.3 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.0 1.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 1.3 GO:0051082 unfolded protein binding(GO:0051082)
0.4 1.2 GO:0000171 ribonuclease MRP activity(GO:0000171)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.1 ST_STAT3_PATHWAY STAT3 Pathway
0.1 1.6 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.1 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.1 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.7 PID_ARF_3PATHWAY Arf1 pathway
0.1 0.6 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.6 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 0.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.5 PID_VEGFR1_PATHWAY VEGFR1 specific signals

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 2.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 1.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.2 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.1 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.1 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.8 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation