Motif ID: Atf4

Z-value: 0.707


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.491.3e-03Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.373 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_+_144896523 4.779 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr1_-_71653162 4.184 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr4_+_43957678 3.336 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chrX_+_103422010 3.316 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr2_+_119351222 2.941 ENSMUST00000028780.3
 Chac1
ChaC, cation transport regulator 1
chr13_+_49682191 2.201 ENSMUST00000172254.1
 Iars
isoleucine-tRNA synthetase
chr4_+_46450892 1.881 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr5_+_93093428 1.757 ENSMUST00000074733.7
 Sept11
septin 11
chr4_-_129189600 1.692 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr19_-_12501996 1.624 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr8_+_75093591 1.520 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr19_+_53140430 1.511 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr13_+_49682100 1.436 ENSMUST00000165316.1
ENSMUST00000047363.7
 Iars

isoleucine-tRNA synthetase

chr4_-_129189512 1.419 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr11_+_100320596 1.394 ENSMUST00000152521.1
 Eif1
eukaryotic translation initiation factor 1
chr4_-_129189646 1.387 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chrX_+_106187100 1.386 ENSMUST00000081593.6
 Pgk1
phosphoglycerate kinase 1
chr3_-_138143352 1.338 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein
chr14_+_63436394 1.298 ENSMUST00000121288.1
 Fam167a
family with sequence similarity 167, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.2 4.8 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
1.4 4.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
1.2 3.6 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 3.3 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.7 2.9 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 1.9 GO:0043486 histone exchange(GO:0043486)
0.4 1.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.4 1.5 GO:1904706 heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.3 1.5 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.1 1.4 GO:0031639 plasminogen activation(GO:0031639)
0.1 1.4 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.3 1.3 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 1.3 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.1 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.3 1.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.3 1.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.2 1.0 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 1.0 GO:0010960 magnesium ion homeostasis(GO:0010960)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 GO:0016607 nuclear speck(GO:0016607)
1.4 4.2 GO:0005577 fibrinogen complex(GO:0005577)
0.3 4.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 3.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 1.5 GO:0005901 caveola(GO:0005901)
0.0 1.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 1.3 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 1.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.2 0.8 GO:0070552 BRISC complex(GO:0070552)
0.1 0.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.3 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.1 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 4.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 4.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.7 4.2 GO:0045340 mercury ion binding(GO:0045340)
1.2 3.6 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.6 2.9 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.5 2.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 1.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.4 1.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.2 1.5 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 1.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 1.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.2 GO:0008483 transaminase activity(GO:0008483)
0.4 1.1 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.3 1.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 1.0 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 1.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 1.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.0 GO:0000049 tRNA binding(GO:0000049)
0.3 0.8 GO:0004813 alanine-tRNA ligase activity(GO:0004813)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 4.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 1.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.1 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 1.0 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway