Motif ID: Atf5

Z-value: 0.679


Transcription factors associated with Atf5:

Gene SymbolEntrez IDGene Name
Atf5 ENSMUSG00000038539.8 Atf5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf5mm10_v2_chr7_-_44815658_44815682-0.391.1e-02Click!


Activity profile for motif Atf5.

activity profile for motif Atf5


Sorted Z-values histogram for motif Atf5

Sorted Z-values for motif Atf5



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf5

PNG image of the network

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Top targets:


Showing 1 to 20 of 123 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 3.369 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chrX_+_41401128 3.159 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr16_+_43503607 3.051 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chrX_+_41401304 2.733 ENSMUST00000076349.5
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr1_-_22805994 2.524 ENSMUST00000097808.4
 Rims1
regulating synaptic membrane exocytosis 1
chr4_-_82705735 2.367 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr1_-_158356258 2.350 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr16_+_38089001 2.230 ENSMUST00000023507.6
 Gsk3b
glycogen synthase kinase 3 beta
chr18_+_64254359 2.151 ENSMUST00000025477.7
 St8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chrX_+_41401476 2.092 ENSMUST00000165288.1
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr13_+_104287855 1.901 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr15_-_102529025 1.869 ENSMUST00000096143.1
 Atf7
activating transcription factor 7
chr18_-_23041641 1.714 ENSMUST00000097651.3
 Nol4
nucleolar protein 4
chr15_-_79164477 1.679 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chrX_-_41911877 1.550 ENSMUST00000047037.8
 Thoc2
THO complex 2
chr4_-_91376433 1.543 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr8_+_54954728 1.522 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr10_+_115384951 1.398 ENSMUST00000036044.8
 Zfc3h1
zinc finger, C3H1-type containing
chr10_+_90071095 1.358 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_-_11322109 1.352 ENSMUST00000084892.5
ENSMUST00000128024.1
 Dpy19l4

dpy-19-like 4 (C. elegans)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 3.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 3.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 2.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 2.5 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.3 2.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.6 2.4 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 2.3 GO:0048813 dendrite morphogenesis(GO:0048813)
0.7 2.2 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.5 2.2 GO:1990743 protein sialylation(GO:1990743)
0.0 1.9 GO:0060976 coronary vasculature development(GO:0060976)
0.4 1.8 GO:0034436 glycoprotein transport(GO:0034436)
0.3 1.7 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.2 1.7 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 1.5 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.0 1.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.5 1.4 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 1.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 1.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 1.3 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 3.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.7 GO:0030175 filopodium(GO:0030175)
0.5 2.5 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 2.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 2.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 2.2 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.8 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.2 1.7 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 1.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 1.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 1.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 1.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.0 GO:0032584 growth cone membrane(GO:0032584)
0.0 1.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.9 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.8 GO:0044308 axonal spine(GO:0044308)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 8.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 3.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 3.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 2.5 GO:0030276 clathrin binding(GO:0030276)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 2.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 1.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.6 1.8 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.3 1.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.6 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.3 1.2 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 1.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.0 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.0 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.9 GO:0005246 calcium channel regulator activity(GO:0005246)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.9 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.0 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 0.8 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 2.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.3 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 2.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.0 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.8 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 0.8 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.8 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.4 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling