Motif ID: Atf6

Z-value: 1.361


Transcription factors associated with Atf6:

Gene SymbolEntrez IDGene Name
Atf6 ENSMUSG00000026663.6 Atf6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf6mm10_v2_chr1_-_170867761_1708677840.278.3e-02Click!


Activity profile for motif Atf6.

activity profile for motif Atf6


Sorted Z-values histogram for motif Atf6

Sorted Z-values for motif Atf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_125995102 9.169 ENSMUST00000046765.8
 Kcnk1
potassium channel, subfamily K, member 1
chr3_+_123267445 9.155 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chrX_+_41401128 6.798 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr6_-_101377897 6.457 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr5_+_134986191 6.448 ENSMUST00000094245.2
 Cldn3
claudin 3
chr12_+_82616885 5.375 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr16_-_23988852 5.369 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr10_-_18743691 4.731 ENSMUST00000019999.5
 D10Bwg1379e
DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed
chr4_+_88094599 4.488 ENSMUST00000097992.3
 Focad
focadhesin
chr15_+_77084367 4.351 ENSMUST00000181870.1
 1700109K24Rik
RIKEN cDNA 1700109K24 gene
chr5_+_137288273 4.070 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr5_-_136170634 3.799 ENSMUST00000041048.1
 Orai2
ORAI calcium release-activated calcium modulator 2
chr8_-_70487314 3.731 ENSMUST00000045286.7
 Tmem59l
transmembrane protein 59-like
chr4_-_149774238 3.603 ENSMUST00000105686.2
 Slc25a33
solute carrier family 25, member 33
chr15_-_77956658 3.568 ENSMUST00000117725.1
ENSMUST00000016696.6
 Foxred2

FAD-dependent oxidoreductase domain containing 2

chr5_+_35056813 3.530 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr16_+_41532999 3.443 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr7_+_126950518 3.227 ENSMUST00000106335.1
ENSMUST00000146017.1
 Sez6l2

seizure related 6 homolog like 2

chr6_-_8778439 3.222 ENSMUST00000115520.1
ENSMUST00000038403.5
ENSMUST00000115518.1
 Ica1


islet cell autoantigen 1


chr10_+_29211637 3.195 ENSMUST00000092627.4
 9330159F19Rik
RIKEN cDNA 9330159F19 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 11.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.4 9.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
1.5 8.9 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 6.6 GO:0001919 regulation of receptor recycling(GO:0001919)
0.8 6.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 5.9 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 5.6 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
1.8 5.4 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.6 5.4 GO:0090166 Golgi disassembly(GO:0090166)
0.1 5.3 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.2 5.2 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.6 5.1 GO:0071569 protein ufmylation(GO:0071569)
0.1 5.0 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 4.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.4 4.5 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.7 4.0 GO:0019695 choline metabolic process(GO:0019695)
0.5 3.8 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.4 3.8 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 3.7 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 3.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 13.5 GO:0043083 synaptic cleft(GO:0043083)
0.0 13.5 GO:0005794 Golgi apparatus(GO:0005794)
0.0 11.5 GO:0030426 growth cone(GO:0030426)
0.7 11.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 11.0 GO:0031594 neuromuscular junction(GO:0031594)
2.3 9.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 9.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 7.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 7.0 GO:0031201 SNARE complex(GO:0031201)
0.3 6.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 4.7 GO:0005657 replication fork(GO:0005657)
0.2 4.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 4.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 4.1 GO:0000139 Golgi membrane(GO:0000139)
0.1 4.0 GO:0043034 costamere(GO:0043034)
0.5 3.7 GO:0005827 polar microtubule(GO:0005827)
0.0 3.6 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 3.4 GO:0043209 myelin sheath(GO:0043209)
0.2 3.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 2.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.8 8.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 7.7 GO:0000149 SNARE binding(GO:0000149)
1.0 6.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 6.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 5.5 GO:0005158 insulin receptor binding(GO:0005158)
0.4 5.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 5.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
1.2 4.7 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.4 4.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 4.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 4.1 GO:0030695 GTPase regulator activity(GO:0030695)
1.0 4.0 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.0 3.9 GO:0008565 protein transporter activity(GO:0008565)
0.9 3.8 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.5 3.8 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 3.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 3.6 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 3.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.4 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 5.1 PID_LKB1_PATHWAY LKB1 signaling events
0.1 4.2 PID_ARF_3PATHWAY Arf1 pathway
0.1 3.5 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 3.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 2.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 2.3 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 2.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.3 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 ST_ADRENERGIC Adrenergic Pathway
0.0 0.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID_SHP2_PATHWAY SHP2 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 10.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.3 8.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 8.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 7.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 5.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 4.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 4.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 4.0 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 3.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 2.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.6 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.5 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 2.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 2.4 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 2.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.3 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 2.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets