Motif ID: Atf7_E4f1

Z-value: 1.432

Transcription factors associated with Atf7_E4f1:

Gene SymbolEntrez IDGene Name
Atf7 ENSMUSG00000052414.9 Atf7
Atf7 ENSMUSG00000071584.1 Atf7
E4f1 ENSMUSG00000024137.8 E4f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf7mm10_v2_chr15_-_102529025_102529025-0.462.2e-03Click!
E4f1mm10_v2_chr17_-_24455265_24455345-0.296.4e-02Click!


Activity profile for motif Atf7_E4f1.

activity profile for motif Atf7_E4f1


Sorted Z-values histogram for motif Atf7_E4f1

Sorted Z-values for motif Atf7_E4f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf7_E4f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_59260878 13.511 ENSMUST00000026084.3
 Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr3_-_36571952 10.035 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr3_+_67374116 9.424 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr8_+_116921735 9.372 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr4_+_111720187 8.990 ENSMUST00000084354.3
 Spata6
spermatogenesis associated 6
chr3_+_67374091 8.689 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr9_-_20976762 8.548 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr6_-_23248264 8.509 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_60893430 8.375 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr3_+_135212557 8.256 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr3_+_40800054 8.127 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr17_-_71526819 7.973 ENSMUST00000024851.9
 Ndc80
NDC80 homolog, kinetochore complex component (S. cerevisiae)
chr1_-_71653162 7.676 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr13_+_8885501 7.542 ENSMUST00000169314.2
 Idi1
isopentenyl-diphosphate delta isomerase
chr13_-_23761223 7.226 ENSMUST00000102964.2
 Hist1h4a
histone cluster 1, H4a
chr13_+_23531044 6.976 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr16_-_23890805 6.968 ENSMUST00000004480.3
 Sst
somatostatin
chr3_-_145649970 6.581 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr15_+_99074968 6.580 ENSMUST00000039665.6
 Troap
trophinin associated protein
chrX_+_170009659 6.389 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 200 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 26.1 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
1.6 19.7 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
1.2 14.9 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
2.4 14.6 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.8 14.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.5 14.5 GO:0034508 centromere complex assembly(GO:0034508)
2.3 13.5 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
1.6 11.4 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
1.8 10.6 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.5 10.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 10.2 GO:0008380 RNA splicing(GO:0008380)
0.3 9.4 GO:0016572 histone phosphorylation(GO:0016572)
2.3 9.2 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.4 8.8 GO:0007530 sex determination(GO:0007530)
0.0 8.7 GO:0006412 translation(GO:0006412)
1.7 8.5 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
1.4 8.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.7 8.3 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.7 7.9 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
2.6 7.7 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 22.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 21.9 GO:0000776 kinetochore(GO:0000776)
0.5 20.4 GO:0097546 ciliary base(GO:0097546)
0.2 15.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.1 14.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.9 14.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.4 14.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 14.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.2 12.0 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.7 11.8 GO:0031045 dense core granule(GO:0031045)
0.7 11.6 GO:0030008 TRAPP complex(GO:0030008)
1.9 11.4 GO:0098536 deuterosome(GO:0098536)
1.0 10.6 GO:0005642 annulate lamellae(GO:0005642)
1.4 10.0 GO:0001940 male pronucleus(GO:0001940)
0.0 9.8 GO:0000790 nuclear chromatin(GO:0000790)
3.0 9.1 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.1 9.1 GO:0036126 sperm flagellum(GO:0036126)
2.0 8.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
2.6 7.7 GO:0005577 fibrinogen complex(GO:0005577)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 29.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 14.9 GO:0017160 Ral GTPase binding(GO:0017160)
1.0 14.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.3 14.1 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
1.1 13.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
4.5 13.5 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.1 12.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 10.6 GO:0017070 U6 snRNA binding(GO:0017070)
1.5 9.2 GO:1990932 5.8S rRNA binding(GO:1990932)
1.1 9.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.2 9.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.8 9.0 GO:0032027 myosin light chain binding(GO:0032027)
0.2 8.9 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.5 8.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.7 8.7 GO:0001618 virus receptor activity(GO:0001618)
1.7 8.3 GO:0043515 kinetochore binding(GO:0043515)
0.5 8.3 GO:0003680 AT DNA binding(GO:0003680)
1.3 7.7 GO:0045340 mercury ion binding(GO:0045340)
0.0 7.7 GO:0042393 histone binding(GO:0042393)
0.2 7.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 15.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 15.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.8 14.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 10.7 PID_BARD1_PATHWAY BARD1 signaling events
0.3 8.5 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 7.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 5.8 PID_PLK1_PATHWAY PLK1 signaling events
0.2 5.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.2 5.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 3.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 3.1 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 3.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 3.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.8 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 2.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 26.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.4 22.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.5 18.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 15.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.9 14.9 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 14.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.4 13.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 11.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.4 10.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 10.8 REACTOME_KINESINS Genes involved in Kinesins
0.4 10.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 10.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.6 10.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.6 8.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 8.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 7.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.5 7.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 6.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 6.1 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 4.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)