Motif ID: Atoh1_Bhlhe23

Z-value: 0.674

Transcription factors associated with Atoh1_Bhlhe23:

Gene SymbolEntrez IDGene Name
Atoh1 ENSMUSG00000073043.4 Atoh1
Bhlhe23 ENSMUSG00000045493.3 Bhlhe23

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe23mm10_v2_chr2_-_180776900_1807769000.391.1e-02Click!


Activity profile for motif Atoh1_Bhlhe23.

activity profile for motif Atoh1_Bhlhe23


Sorted Z-values histogram for motif Atoh1_Bhlhe23

Sorted Z-values for motif Atoh1_Bhlhe23



Network of associatons between targets according to the STRING database.



First level regulatory network of Atoh1_Bhlhe23

PNG image of the network

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Top targets:


Showing 1 to 20 of 102 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_43235856 3.870 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr1_+_15287259 3.392 ENSMUST00000175681.1
 Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr1_+_177444653 3.386 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr17_-_6449571 3.342 ENSMUST00000180035.1
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr2_+_62046580 2.611 ENSMUST00000054484.8
 Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr5_-_66618636 2.570 ENSMUST00000162382.1
ENSMUST00000160870.1
ENSMUST00000087256.5
ENSMUST00000160103.1
ENSMUST00000162349.1
 Apbb2




amyloid beta (A4) precursor protein-binding, family B, member 2




chr2_+_62046623 2.569 ENSMUST00000112480.2
 Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr2_-_79456750 2.560 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr9_-_21918089 2.520 ENSMUST00000128442.1
ENSMUST00000119055.1
ENSMUST00000122211.1
ENSMUST00000115351.3
 Rab3d



RAB3D, member RAS oncogene family



chr10_+_69706326 2.386 ENSMUST00000182992.1
 Ank3
ankyrin 3, epithelial
chr2_+_62046462 2.382 ENSMUST00000102735.3
 Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr13_-_97747399 2.340 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr9_+_72985504 2.072 ENSMUST00000156879.1
 Ccpg1
cell cycle progression 1
chr9_+_72985568 2.066 ENSMUST00000150826.2
ENSMUST00000085350.4
ENSMUST00000140675.1
 Ccpg1


cell cycle progression 1


chr5_-_66618772 2.002 ENSMUST00000162994.1
ENSMUST00000159512.1
ENSMUST00000159786.1
 Apbb2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr2_-_29253001 1.934 ENSMUST00000071201.4
 Ntng2
netrin G2
chr5_+_129096740 1.905 ENSMUST00000056617.7
ENSMUST00000156437.1
 Gpr133

G protein-coupled receptor 133

chr11_+_58954675 1.895 ENSMUST00000047697.5
ENSMUST00000108817.3
 Trim17
Hist3h2a
tripartite motif-containing 17
histone cluster 3, H2a
chr15_-_91191733 1.858 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr3_-_84259812 1.763 ENSMUST00000107691.1
 Trim2
tripartite motif-containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.6 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 5.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 4.8 GO:0007050 cell cycle arrest(GO:0007050)
0.1 4.5 GO:0021766 hippocampus development(GO:0021766)
1.0 4.1 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.6 2.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.5 2.5 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.2 2.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.6 1.9 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.2 1.9 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 1.9 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 1.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.4 1.3 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.1 1.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.3 1.1 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.1 1.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 1.0 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097) negative regulation of lymphocyte migration(GO:2000402)
0.2 1.0 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 1.0 GO:0000045 autophagosome assembly(GO:0000045)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.6 GO:0097441 basilar dendrite(GO:0097441)
0.1 4.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 3.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 2.5 GO:0042588 zymogen granule(GO:0042588)
0.1 2.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 2.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.8 GO:0031430 M band(GO:0031430)
0.0 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.0 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.0 GO:0005776 autophagosome(GO:0005776)
0.0 0.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.7 GO:0070938 contractile ring(GO:0070938)
0.0 0.7 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 6.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 5.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.6 GO:0070888 E-box binding(GO:0070888)
0.2 3.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 2.7 GO:0030507 spectrin binding(GO:0030507)
0.0 2.7 GO:0030674 protein binding, bridging(GO:0030674)
0.1 2.5 GO:0031489 myosin V binding(GO:0031489)
0.1 2.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.4 1.3 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 1.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.1 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.1 1.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.0 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.9 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.9 GO:0016208 AMP binding(GO:0016208)
0.0 0.8 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 0.7 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 0.7 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.0 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.5 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.4 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects