Motif ID: Bhlhe40

Z-value: 0.571


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660616_108660682-0.603.0e-05Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Showing 1 to 20 of 92 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148039097 3.803 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_148039035 3.798 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr7_+_121707189 3.575 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr4_-_148038769 3.026 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr16_-_44139630 1.546 ENSMUST00000137557.1
ENSMUST00000147025.1
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr5_-_123572976 1.495 ENSMUST00000031388.8
 Vps33a
vacuolar protein sorting 33A (yeast)
chr7_+_35802593 1.471 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr16_-_44139003 1.462 ENSMUST00000124102.1
 Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr16_+_8830093 1.355 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr5_+_65199691 1.326 ENSMUST00000041892.8
 Wdr19
WD repeat domain 19
chr11_+_97450136 1.194 ENSMUST00000107601.1
 Arhgap23
Rho GTPase activating protein 23
chr11_+_55204319 1.070 ENSMUST00000108872.2
ENSMUST00000147506.1
ENSMUST00000020499.7
 Slc36a1


solute carrier family 36 (proton/amino acid symporter), member 1


chr12_-_3426700 1.050 ENSMUST00000180149.1
 1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr11_-_75454656 1.009 ENSMUST00000173320.1
 Wdr81
WD repeat domain 81
chr16_+_5233615 0.924 ENSMUST00000100196.2
ENSMUST00000049207.8
 Alg1

asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)

chr12_+_86947343 0.902 ENSMUST00000038369.4
 2310044G17Rik
RIKEN cDNA 2310044G17 gene
chr4_-_141790891 0.898 ENSMUST00000038014.4
ENSMUST00000153880.1
 Dnajc16

DnaJ (Hsp40) homolog, subfamily C, member 16

chrX_-_7188713 0.885 ENSMUST00000004428.7
 Clcn5
chloride channel 5
chr1_+_5083105 0.855 ENSMUST00000044369.7
 Atp6v1h
ATPase, H+ transporting, lysosomal V1 subunit H
chr7_-_35802968 0.837 ENSMUST00000061586.4
 Zfp507
zinc finger protein 507

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 7.6 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 3.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 3.7 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 1.5 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.1 1.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.3 1.3 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055)
0.2 1.1 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.2 1.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 1.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.9 GO:0007035 vacuolar acidification(GO:0007035)
0.1 0.8 GO:0030242 pexophagy(GO:0030242)
0.0 0.7 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 0.6 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 0.6 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.6 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.6 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.5 4.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 1.8 GO:0033263 CORVET complex(GO:0033263)
0.1 1.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.2 1.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.6 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.5 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 7.6 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.2 4.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 3.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 1.1 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.2 0.6 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.6 GO:0008373 sialyltransferase activity(GO:0008373)
0.1 0.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.4 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.4 GO:0050681 androgen receptor binding(GO:0050681)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.3 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 0.2 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 4.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.1 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.4 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway