Motif ID: Brca1

Z-value: 0.456


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_1015518930.114.9e-01Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Showing 1 to 20 of 183 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.093 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_44617310 2.073 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr1_-_75278345 1.849 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chr18_-_47333311 1.684 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr7_-_144939823 1.302 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr11_+_97415527 1.181 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr16_-_16829276 1.131 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr8_-_47990535 1.059 ENSMUST00000057561.7
 Wwc2
WW, C2 and coiled-coil domain containing 2
chr11_-_106998483 0.955 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr10_-_33624587 0.871 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr1_+_66386968 0.753 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr6_+_14901344 0.734 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr13_-_49320219 0.689 ENSMUST00000110086.1
 Fgd3
FYVE, RhoGEF and PH domain containing 3
chr9_-_109082372 0.675 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr14_-_67715585 0.660 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr1_+_74791516 0.654 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr16_+_44394771 0.631 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr17_-_70853482 0.630 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr2_-_28916668 0.627 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr11_-_98625661 0.605 ENSMUST00000104933.1
 Gm12355
predicted gene 12355

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.2 1.3 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 1.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 1.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 0.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.2 0.5 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 0.5 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 0.5 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.5 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.8 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 0.6 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 0.5 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.5 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.1 0.4 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 0.4 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.4 GO:0000125 PCAF complex(GO:0000125)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 2.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.1 0.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 0.7 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 0.6 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.5 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.4 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.4 GO:0031419 cobalamin binding(GO:0031419)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID_MYC_PATHWAY C-MYC pathway
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 1.0 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.5 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 0.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.4 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC