Motif ID: Cebpb

Z-value: 0.693


Transcription factors associated with Cebpb:

Gene SymbolEntrez IDGene Name
Cebpb ENSMUSG00000056501.3 Cebpb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cebpbmm10_v2_chr2_+_167688915_1676889730.603.5e-05Click!


Activity profile for motif Cebpb.

activity profile for motif Cebpb


Sorted Z-values histogram for motif Cebpb

Sorted Z-values for motif Cebpb



Network of associatons between targets according to the STRING database.



First level regulatory network of Cebpb

PNG image of the network

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Top targets:


Showing 1 to 20 of 152 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_15924928 3.382 ENSMUST00000025542.3
 Psat1
phosphoserine aminotransferase 1
chr8_+_75093591 2.816 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr12_+_88953399 2.732 ENSMUST00000057634.7
 Nrxn3
neurexin III
chr5_+_75152274 2.696 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr2_+_118111876 2.450 ENSMUST00000039559.8
 Thbs1
thrombospondin 1
chr13_-_49309217 2.356 ENSMUST00000110087.2
 Fgd3
FYVE, RhoGEF and PH domain containing 3
chr2_+_25180737 2.292 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr14_+_65971049 2.155 ENSMUST00000128539.1
 Clu
clusterin
chr1_-_71653162 2.131 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr4_-_148087961 2.100 ENSMUST00000030865.8
 Agtrap
angiotensin II, type I receptor-associated protein
chr15_-_37459327 2.097 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr19_-_50678642 2.078 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr14_+_65971164 2.017 ENSMUST00000144619.1
 Clu
clusterin
chr14_+_65970610 1.956 ENSMUST00000127387.1
 Clu
clusterin
chr12_-_56535047 1.928 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr14_+_65970804 1.910 ENSMUST00000138191.1
 Clu
clusterin
chr3_-_57575760 1.813 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr7_+_126862431 1.598 ENSMUST00000132808.1
 Hirip3
HIRA interacting protein 3
chr18_+_4994600 1.505 ENSMUST00000140448.1
 Svil
supervillin
chr4_+_136172367 1.492 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 8.0 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 3.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.6 3.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.7 2.8 GO:1904706 heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.9 2.7 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 2.7 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.8 2.4 GO:0010752 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752)
0.0 2.4 GO:0046847 filopodium assembly(GO:0046847)
0.2 2.3 GO:0014807 regulation of somitogenesis(GO:0014807)
0.7 2.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.1 2.1 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 2.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.6 1.9 GO:0021759 globus pallidus development(GO:0021759)
0.3 1.9 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.3 1.8 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.2 1.5 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.1 1.5 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.5 1.4 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.3 1.4 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.3 1.4 GO:0072675 osteoclast fusion(GO:0072675)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 8.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 5.6 GO:0005667 transcription factor complex(GO:0005667)
1.5 4.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 2.7 GO:0005902 microvillus(GO:0005902)
0.0 2.7 GO:0005901 caveola(GO:0005901)
0.0 2.1 GO:0043195 terminal bouton(GO:0043195)
0.0 2.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.3 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.2 0.7 GO:0071942 XPC complex(GO:0071942)
0.1 0.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.6 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.5 GO:0001533 cornified envelope(GO:0001533)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.4 GO:0097255 R2TP complex(GO:0097255)
0.1 0.3 GO:0033193 Lsd1/2 complex(GO:0033193)
0.1 0.3 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.0 GO:0051787 misfolded protein binding(GO:0051787)
0.1 3.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 3.4 GO:0008483 transaminase activity(GO:0008483)
0.7 2.8 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.5 2.7 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 2.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 2.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.8 2.4 GO:0070052 collagen V binding(GO:0070052)
0.4 2.1 GO:0045340 mercury ion binding(GO:0045340)
0.0 2.1 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.5 1.9 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 1.7 GO:0005522 profilin binding(GO:0005522)
0.0 1.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 1.4 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.2 1.4 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.3 1.2 GO:0004074 biliverdin reductase activity(GO:0004074)
0.3 1.0 GO:0071723 lipopeptide binding(GO:0071723)
0.0 1.0 GO:0003684 damaged DNA binding(GO:0003684)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.1 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.4 PID_NECTIN_PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 4.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 3.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 3.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 3.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 2.7 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.2 2.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.9 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.5 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.3 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.7 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling