Motif ID: Cenpb

Z-value: 1.362


Transcription factors associated with Cenpb:

Gene SymbolEntrez IDGene Name
Cenpb ENSMUSG00000068267.4 Cenpb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cenpbmm10_v2_chr2_-_131179985_131180092-0.153.7e-01Click!


Activity profile for motif Cenpb.

activity profile for motif Cenpb


Sorted Z-values histogram for motif Cenpb

Sorted Z-values for motif Cenpb



Network of associatons between targets according to the STRING database.



First level regulatory network of Cenpb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_98662227 32.491 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr2_+_172550991 11.052 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr13_+_48261427 7.627 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr8_-_87959560 7.079 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr9_-_8004585 6.570 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr16_-_17125106 6.514 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr6_+_66535418 5.386 ENSMUST00000101343.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr17_+_87282880 5.268 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr14_+_65805832 5.182 ENSMUST00000022612.3
 Pbk
PDZ binding kinase
chr10_+_25359798 5.147 ENSMUST00000053748.8
 Epb4.1l2
erythrocyte protein band 4.1-like 2
chr4_-_68954351 5.146 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr5_-_99037342 4.419 ENSMUST00000161490.1
 Prkg2
protein kinase, cGMP-dependent, type II
chr13_-_23698454 4.311 ENSMUST00000102967.1
 Hist1h4c
histone cluster 1, H4c
chr6_-_94700137 4.235 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr12_-_45074112 4.224 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr10_+_67979709 4.207 ENSMUST00000117086.1
 Rtkn2
rhotekin 2
chr1_+_184034381 4.081 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr8_-_25201349 4.029 ENSMUST00000084512.4
ENSMUST00000084030.4
 Tacc1

transforming, acidic coiled-coil containing protein 1

chr11_+_101316917 4.000 ENSMUST00000151385.1
 Psme3
proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
chr16_-_18811972 3.875 ENSMUST00000000028.7
ENSMUST00000115585.1
 Cdc45

cell division cycle 45


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 11.1 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 8.7 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
1.9 7.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.6 7.6 GO:0051601 exocyst localization(GO:0051601)
1.1 6.6 GO:0060242 contact inhibition(GO:0060242)
0.6 5.4 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 5.3 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.3 5.1 GO:0042711 maternal behavior(GO:0042711)
0.5 4.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 4.4 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.2 4.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 4.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
1.4 4.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.8 4.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.2 4.0 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.3 3.9 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 3.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 3.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.3 3.5 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.9 3.4 GO:0035262 gonad morphogenesis(GO:0035262)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 GO:0005643 nuclear pore(GO:0005643)
0.4 7.6 GO:0000145 exocyst(GO:0000145)
2.2 6.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 4.8 GO:0042555 MCM complex(GO:0042555)
0.4 4.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 4.3 GO:0000788 nuclear nucleosome(GO:0000788)
1.0 4.0 GO:0008537 proteasome activator complex(GO:0008537)
0.0 4.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.3 3.9 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.3 3.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 3.9 GO:0016607 nuclear speck(GO:0016607)
0.6 3.6 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.4 3.3 GO:0005883 neurofilament(GO:0005883)
0.1 3.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 3.3 GO:0005923 bicellular tight junction(GO:0005923)
0.2 3.1 GO:0000800 lateral element(GO:0000800)
0.0 2.8 GO:0005657 replication fork(GO:0005657)
0.2 2.6 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 2.6 GO:0005839 proteasome core complex(GO:0005839)
0.1 2.6 GO:0001741 XY body(GO:0001741)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.5 8.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 6.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 5.0 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 4.9 GO:0003697 single-stranded DNA binding(GO:0003697)
1.1 4.4 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 4.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 4.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.4 4.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 3.9 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 3.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 3.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 3.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 3.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 3.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.4 3.1 GO:0000150 recombinase activity(GO:0000150)
0.1 3.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
1.0 3.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.9 2.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 2.7 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 11.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 6.5 PID_ATR_PATHWAY ATR signaling pathway
0.1 4.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 4.3 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 3.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.9 PID_FGF_PATHWAY FGF signaling pathway
0.3 2.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 2.6 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.6 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 1.4 PID_MYC_PATHWAY C-MYC pathway
0.0 1.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.2 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 SIG_CHEMOTAXIS Genes related to chemotaxis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.8 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.5 8.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 6.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 5.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.3 5.4 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2 5.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 4.4 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 4.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.4 4.2 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 3.9 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 3.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 3.1 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4 2.9 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.3 2.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 2.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 2.1 REACTOME_TRANSLATION Genes involved in Translation
0.0 1.9 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 1.5 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 1.5 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC