Motif ID: Chd1_Pml

Z-value: 4.415

Transcription factors associated with Chd1_Pml:

Gene SymbolEntrez IDGene Name
Chd1 ENSMUSG00000023852.7 Chd1
Pml ENSMUSG00000036986.10 Pml

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Chd1mm10_v2_chr17_+_15704963_157049940.279.1e-02Click!
Pmlmm10_v2_chr9_-_58249660_58249672-0.086.3e-01Click!


Activity profile for motif Chd1_Pml.

activity profile for motif Chd1_Pml


Sorted Z-values histogram for motif Chd1_Pml

Sorted Z-values for motif Chd1_Pml



Network of associatons between targets according to the STRING database.



First level regulatory network of Chd1_Pml

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66286224 32.252 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chrX_+_69360294 31.354 ENSMUST00000033532.6
 Aff2
AF4/FMR2 family, member 2
chr5_-_106458440 21.566 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr2_-_34372004 21.199 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chr6_+_99692679 20.509 ENSMUST00000101122.1
 Gpr27
G protein-coupled receptor 27
chr4_-_123664725 20.017 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1
chr10_-_43174521 19.369 ENSMUST00000040275.7
 Sobp
sine oculis-binding protein homolog (Drosophila)
chr15_+_89499598 18.893 ENSMUST00000109309.1
 Shank3
SH3/ankyrin domain gene 3
chr10_+_39732099 18.242 ENSMUST00000019986.6
 Rev3l
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr16_+_44173271 17.753 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr7_+_57591147 17.496 ENSMUST00000039697.7
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr4_+_124657646 17.453 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr18_+_64340225 17.425 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr11_-_6065737 16.975 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr1_+_167001417 16.935 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr16_+_44173239 16.800 ENSMUST00000119746.1
 Gm608
predicted gene 608
chr8_-_124434323 16.581 ENSMUST00000140012.1
 Pgbd5
piggyBac transposable element derived 5
chr4_-_46991842 16.280 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr6_-_39206782 16.278 ENSMUST00000002305.8
 Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr2_+_145167706 16.216 ENSMUST00000110007.1
 Slc24a3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,079 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 99.8 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.0 69.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
3.6 67.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.6 62.7 GO:0086010 membrane depolarization during action potential(GO:0086010)
4.0 59.6 GO:0060081 membrane hyperpolarization(GO:0060081)
1.3 53.8 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
8.7 52.0 GO:0042276 error-prone translesion synthesis(GO:0042276)
4.4 39.9 GO:0097107 postsynaptic density assembly(GO:0097107)
1.4 39.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.0 36.9 GO:2001222 regulation of neuron migration(GO:2001222)
1.3 34.8 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
11.5 34.5 GO:0060466 activation of meiosis involved in egg activation(GO:0060466)
1.3 32.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
2.3 32.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 32.5 GO:0006813 potassium ion transport(GO:0006813)
3.6 32.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.5 32.0 GO:0007413 axonal fasciculation(GO:0007413)
0.9 31.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
6.3 31.4 GO:0035063 nuclear speck organization(GO:0035063)
2.0 30.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 370 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 355.8 GO:0016021 integral component of membrane(GO:0016021)
1.0 284.0 GO:0099572 postsynaptic specialization(GO:0099572)
0.3 145.6 GO:0005768 endosome(GO:0005768)
0.5 118.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
1.2 109.5 GO:0005905 clathrin-coated pit(GO:0005905)
3.2 101.3 GO:0043194 axon initial segment(GO:0043194)
2.5 100.7 GO:0032809 neuronal cell body membrane(GO:0032809)
2.1 86.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
2.4 76.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 70.0 GO:0000139 Golgi membrane(GO:0000139)
1.1 62.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
8.9 53.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.2 52.2 GO:0031410 cytoplasmic vesicle(GO:0031410)
1.7 45.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.5 43.9 GO:0008021 synaptic vesicle(GO:0008021)
0.8 42.0 GO:0031941 filamentous actin(GO:0031941)
0.7 42.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.5 42.0 GO:0055037 recycling endosome(GO:0055037)
4.1 40.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
3.0 38.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 576 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 169.0 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.9 112.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 112.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.5 102.1 GO:0008017 microtubule binding(GO:0008017)
1.0 99.4 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.5 91.9 GO:0005096 GTPase activator activity(GO:0005096)
1.6 80.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.7 59.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.5 59.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
2.1 59.0 GO:0017075 syntaxin-1 binding(GO:0017075)
3.4 54.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.9 51.6 GO:0030507 spectrin binding(GO:0030507)
0.4 47.9 GO:0017124 SH3 domain binding(GO:0017124)
4.2 46.6 GO:0002151 G-quadruplex RNA binding(GO:0002151)
1.8 44.3 GO:0043274 phospholipase binding(GO:0043274)
0.6 43.3 GO:0000149 SNARE binding(GO:0000149)
1.9 42.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.5 42.2 GO:0019208 phosphatase regulator activity(GO:0019208)
0.3 42.2 GO:0000287 magnesium ion binding(GO:0000287)
2.2 39.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 118.1 PID_REELIN_PATHWAY Reelin signaling pathway
1.8 103.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
1.1 79.3 PID_LKB1_PATHWAY LKB1 signaling events
0.5 59.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
3.2 53.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
2.5 44.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.6 37.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.9 36.5 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.7 35.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
1.5 35.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.6 30.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
1.3 30.3 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.9 30.3 PID_BCR_5PATHWAY BCR signaling pathway
2.2 28.9 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.4 28.4 PID_P53_REGULATION_PATHWAY p53 pathway
0.8 25.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
1.5 24.8 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
1.2 24.4 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.8 23.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.8 21.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 139.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
2.3 81.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
2.8 64.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.8 59.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 57.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.7 53.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
2.2 49.1 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
2.0 47.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.5 45.1 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
1.3 43.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.4 42.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
2.0 41.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
1.8 41.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
3.0 39.0 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
1.8 37.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
2.7 35.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
2.1 34.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.7 34.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
2.2 33.6 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.9 31.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases