Motif ID: Clock

Z-value: 0.417


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_76304548-0.163.2e-01Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Showing 1 to 20 of 161 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 1.655 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr7_-_144939823 1.556 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr5_-_22344690 1.301 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr6_-_49214954 1.237 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr2_+_164769892 1.049 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr1_-_75219245 0.977 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr14_-_20181773 0.941 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr5_+_93093428 0.854 ENSMUST00000074733.7
 Sept11
septin 11
chr15_+_39076885 0.829 ENSMUST00000067072.3
 Cthrc1
collagen triple helix repeat containing 1
chr11_+_101316200 0.825 ENSMUST00000142640.1
ENSMUST00000019470.7
 Psme3

proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)

chr11_+_101316917 0.824 ENSMUST00000151385.1
 Psme3
proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
chr1_-_12991109 0.803 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr4_-_97778042 0.780 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr16_+_32608973 0.701 ENSMUST00000120680.1
 Tfrc
transferrin receptor
chr4_-_133756769 0.689 ENSMUST00000008024.6
 Arid1a
AT rich interactive domain 1A (SWI-like)
chr8_+_58912257 0.665 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr6_-_47813512 0.651 ENSMUST00000077290.7
 Pdia4
protein disulfide isomerase associated 4
chr11_+_94629741 0.632 ENSMUST00000021239.6
 Lrrc59
leucine rich repeat containing 59
chr4_-_57143437 0.623 ENSMUST00000095076.3
ENSMUST00000030142.3
 Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr4_-_97584605 0.623 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.2 1.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 1.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 1.5 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.3 1.3 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.2 1.0 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.3 0.9 GO:1903334 positive regulation of protein folding(GO:1903334)
0.1 0.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 0.8 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.1 0.8 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 0.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.7 GO:0033572 transferrin transport(GO:0033572)
0.1 0.6 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.6 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 0.6 GO:0090209 negative regulation of triglyceride metabolic process(GO:0090209)
0.0 0.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.2 0.5 GO:0070889 platelet alpha granule organization(GO:0070889)
0.1 0.5 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.1 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.5 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.6 GO:0008537 proteasome activator complex(GO:0008537)
0.0 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 0.6 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.6 GO:0000125 PCAF complex(GO:0000125)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.5 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.4 GO:0001651 dense fibrillar component(GO:0001651)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.4 GO:0032797 SMN complex(GO:0032797)
0.1 0.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.3 GO:0043202 lysosomal lumen(GO:0043202)
0.1 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.3 GO:0070552 BRISC complex(GO:0070552)
0.1 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.2 1.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 1.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 1.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.8 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 0.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 0.7 GO:0004998 transferrin receptor activity(GO:0004998)
0.2 0.7 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.1 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.6 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle