Motif ID: Creb1

Z-value: 1.500


Transcription factors associated with Creb1:

Gene SymbolEntrez IDGene Name
Creb1 ENSMUSG00000025958.8 Creb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb1mm10_v2_chr1_+_64532790_64532815-0.324.2e-02Click!


Activity profile for motif Creb1.

activity profile for motif Creb1


Sorted Z-values histogram for motif Creb1

Sorted Z-values for motif Creb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_121033960 5.137 ENSMUST00000020439.4
ENSMUST00000175867.1
 Wif1

Wnt inhibitory factor 1

chr12_+_108334341 4.433 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr4_+_105157339 4.162 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr15_-_76710486 4.140 ENSMUST00000036852.7
 Recql4
RecQ protein-like 4
chr4_-_58553553 4.075 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr14_-_103843685 3.925 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr4_-_58553311 3.747 ENSMUST00000107571.1
ENSMUST00000055018.4
 Lpar1

lysophosphatidic acid receptor 1

chr7_-_38107490 3.729 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr19_+_6084983 3.690 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr10_-_7792795 3.660 ENSMUST00000065124.1
 6530403G13Rik
RIKEN cDNA 6530403G13 gene
chr2_+_156840966 3.621 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr12_-_56535047 3.226 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr2_+_27886416 3.143 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr17_+_46646225 2.980 ENSMUST00000002844.7
ENSMUST00000113429.1
ENSMUST00000113430.1
 Mrpl2


mitochondrial ribosomal protein L2


chr7_-_30664986 2.849 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr10_-_87493651 2.785 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr7_-_118533298 2.753 ENSMUST00000098090.3
ENSMUST00000032887.3
 Coq7

demethyl-Q 7

chr7_-_79715669 2.687 ENSMUST00000184137.1
ENSMUST00000183846.1
 Kif7

kinesin family member 7

chr19_-_10949238 2.643 ENSMUST00000025639.6
 Ccdc86
coiled-coil domain containing 86
chr10_-_30200492 2.595 ENSMUST00000099985.4
 Cenpw
centromere protein W

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 9.9 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.6 7.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 7.0 GO:0007018 microtubule-based movement(GO:0007018)
0.1 5.4 GO:0006270 DNA replication initiation(GO:0006270)
0.1 5.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.4 4.6 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.4 4.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 4.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.7 4.1 GO:0045875 DNA strand renaturation(GO:0000733) negative regulation of sister chromatid cohesion(GO:0045875)
1.3 3.9 GO:0014826 vein smooth muscle contraction(GO:0014826)
1.2 3.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.1 3.6 GO:0032543 mitochondrial translation(GO:0032543)
1.1 3.2 GO:0021759 globus pallidus development(GO:0021759)
0.5 3.2 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.3 3.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
1.0 3.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.5 2.9 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.2 2.9 GO:0015693 magnesium ion transport(GO:0015693)
0.9 2.8 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.7 2.8 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.9 GO:0043198 dendritic shaft(GO:0043198)
0.1 9.0 GO:0005871 kinesin complex(GO:0005871)
0.0 6.5 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 6.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 5.9 GO:0035869 ciliary transition zone(GO:0035869)
0.7 4.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 4.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 4.1 GO:0005811 lipid particle(GO:0005811)
0.1 3.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 3.7 GO:0008278 cohesin complex(GO:0008278)
0.0 3.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.6 3.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.5 3.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 3.2 GO:0000793 condensed chromosome(GO:0000793)
1.0 3.1 GO:0005588 collagen type V trimer(GO:0005588)
0.2 3.1 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 2.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.4 2.8 GO:0070652 HAUS complex(GO:0070652)
0.9 2.6 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 9.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 9.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 5.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 4.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 4.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 4.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 4.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 4.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.8 4.1 GO:0000405 bubble DNA binding(GO:0000405)
0.1 4.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 4.0 GO:0003777 microtubule motor activity(GO:0003777)
1.3 3.9 GO:0004962 endothelin receptor activity(GO:0004962)
0.3 3.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
1.1 3.2 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.3 3.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 3.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 3.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 2.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 2.8 GO:0004497 monooxygenase activity(GO:0004497)
0.1 2.8 GO:0043425 bHLH transcription factor binding(GO:0043425)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.6 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 6.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 5.4 PID_E2F_PATHWAY E2F transcription factor network
0.2 5.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 5.1 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 3.9 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 3.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 3.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.2 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 3.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 1.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 1.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.6 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 7.5 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.5 4.9 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.3 4.9 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.6 4.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.2 4.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 3.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 2.4 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 2.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 2.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 2.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.9 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.9 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.9 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 1.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.9 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.8 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 1.7 REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 1.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis