Motif ID: Creb3

Z-value: 0.759


Transcription factors associated with Creb3:

Gene SymbolEntrez IDGene Name
Creb3 ENSMUSG00000028466.9 Creb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3mm10_v2_chr4_+_43562672_43562947-0.481.6e-03Click!


Activity profile for motif Creb3.

activity profile for motif Creb3


Sorted Z-values histogram for motif Creb3

Sorted Z-values for motif Creb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_71546745 7.586 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr14_-_79301623 6.881 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chrX_-_60893430 6.318 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_-_135251209 6.056 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr15_+_79516396 6.053 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr7_-_45092130 5.312 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45091713 5.285 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr2_-_105399286 4.588 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr7_-_25250720 3.572 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr11_-_94653964 3.475 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr2_-_150668198 3.065 ENSMUST00000028944.3
 Acss1
acyl-CoA synthetase short-chain family member 1
chr4_+_3938888 3.049 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr18_+_84720019 2.879 ENSMUST00000161429.1
ENSMUST00000052501.1
 Fam69c

family with sequence similarity 69, member C

chr3_-_36571952 2.808 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr7_-_45092198 2.649 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
 Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr7_-_144939823 2.556 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr7_+_128523576 2.361 ENSMUST00000033136.7
 Bag3
BCL2-associated athanogene 3
chr2_+_119112793 2.347 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr4_-_117182623 2.324 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr4_+_47474652 2.259 ENSMUST00000065678.5
ENSMUST00000137461.1
ENSMUST00000125622.1
 Sec61b


Sec61 beta subunit



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 7.6 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.0 7.1 GO:0006621 protein retention in ER lumen(GO:0006621)
1.7 6.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.3 6.3 GO:0007530 sex determination(GO:0007530)
2.0 6.1 GO:1990523 bone regeneration(GO:1990523)
0.1 5.2 GO:0032526 response to retinoic acid(GO:0032526)
0.7 3.6 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.7 3.5 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
1.0 3.1 GO:0006083 acetate metabolic process(GO:0006083)
0.2 2.8 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 2.8 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.4 2.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.8 2.5 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.2 2.5 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.3 2.4 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.8 2.3 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.8 2.3 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.5 2.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.5 2.0 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.2 2.0 GO:0002227 innate immune response in mucosa(GO:0002227)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.3 6.1 GO:0031527 filopodium membrane(GO:0031527)
0.1 3.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.7 3.5 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.4 2.8 GO:0001940 male pronucleus(GO:0001940)
0.0 2.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 2.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 2.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.4 GO:0031970 organelle envelope lumen(GO:0031970)
0.0 2.4 GO:0030018 Z disc(GO:0030018)
0.8 2.3 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 2.3 GO:0000800 lateral element(GO:0000800)
0.1 2.3 GO:0035371 microtubule plus-end(GO:0035371)
0.4 2.0 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 2.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 1.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 1.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.2 GO:0005509 calcium ion binding(GO:0005509)
0.1 9.1 GO:0003727 single-stranded RNA binding(GO:0003727)
1.8 7.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.2 6.7 GO:0070412 R-SMAD binding(GO:0070412)
0.3 6.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 6.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 6.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 5.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 3.5 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 3.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.0 3.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 2.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.4 2.5 GO:0008312 7S RNA binding(GO:0008312)
0.1 2.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 2.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.3 2.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 2.3 GO:0048408 epidermal growth factor binding(GO:0048408)
0.5 2.3 GO:0000150 recombinase activity(GO:0000150)
0.1 2.3 GO:0051010 microtubule plus-end binding(GO:0051010)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 5.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.0 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.5 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.5 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 1.4 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.1 0.9 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.1 0.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.6 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 0.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.5 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 6.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.8 3.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 3.0 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 2.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 2.6 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.4 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.3 REACTOME_KINESINS Genes involved in Kinesins
0.0 2.3 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.0 2.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.9 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 1.7 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.6 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 1.3 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.2 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.1 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism