Motif ID: Crem_Jdp2

Z-value: 0.550

Transcription factors associated with Crem_Jdp2:

Gene SymbolEntrez IDGene Name
Crem ENSMUSG00000063889.10 Crem
Jdp2 ENSMUSG00000034271.9 Jdp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cremmm10_v2_chr18_-_3281036_3281132-0.305.8e-02Click!
Jdp2mm10_v2_chr12_+_85599388_85599416-0.278.4e-02Click!


Activity profile for motif Crem_Jdp2.

activity profile for motif Crem_Jdp2


Sorted Z-values histogram for motif Crem_Jdp2

Sorted Z-values for motif Crem_Jdp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Crem_Jdp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.586 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_+_43952999 3.974 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr17_+_43953191 3.854 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr1_-_79440039 3.211 ENSMUST00000049972.4
 Scg2
secretogranin II
chr11_-_84525514 3.038 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr5_-_106458440 2.758 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr1_+_74791516 2.534 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr11_+_84525669 2.403 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene

chr3_+_125404072 2.232 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr11_+_84525647 1.953 ENSMUST00000134800.1
 1500016L03Rik
RIKEN cDNA 1500016L03 gene
chr3_+_125404292 1.951 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr19_-_5085483 1.838 ENSMUST00000140389.1
ENSMUST00000151413.1
ENSMUST00000077066.7
 Tmem151a


transmembrane protein 151A


chr9_-_52679429 1.734 ENSMUST00000098768.2
 AI593442
expressed sequence AI593442
chr7_-_137314394 1.697 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr7_-_142899985 1.633 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr16_-_16829276 1.617 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr12_+_79130777 1.514 ENSMUST00000021550.6
 Arg2
arginase type II
chr5_-_69341699 1.357 ENSMUST00000054095.4
 Kctd8
potassium channel tetramerisation domain containing 8
chr2_+_143546144 1.349 ENSMUST00000028905.9
 Pcsk2
proprotein convertase subtilisin/kexin type 2
chr8_-_24438937 1.334 ENSMUST00000052622.4
 1810011O10Rik
RIKEN cDNA 1810011O10 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.9 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
1.1 6.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 3.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
1.0 3.0 GO:0072284 cervix development(GO:0060067) metanephric S-shaped body morphogenesis(GO:0072284) anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.3 2.5 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.5 2.2 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.0 2.0 GO:0001709 cell fate determination(GO:0001709)
0.0 1.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.4 1.6 GO:0042414 epinephrine metabolic process(GO:0042414)
0.4 1.5 GO:0090467 regulation of amino acid import(GO:0010958) L-arginine import(GO:0043091) arginine import(GO:0090467)
0.1 1.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.4 1.3 GO:0030070 insulin processing(GO:0030070)
0.4 1.3 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1 1.3 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.4 1.2 GO:0035973 aggrephagy(GO:0035973)
0.1 1.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 1.1 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 1.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 1.0 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.1 1.0 GO:0032534 regulation of microvillus assembly(GO:0032534)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0030141 secretory granule(GO:0030141)
0.1 2.4 GO:0031045 dense core granule(GO:0031045)
0.5 1.6 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.4 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 1.3 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 1.3 GO:0097546 ciliary base(GO:0097546)
0.2 1.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.0 1.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 1.0 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.1 1.0 GO:0071437 invadopodium(GO:0071437)
0.0 1.0 GO:0005769 early endosome(GO:0005769)
0.3 0.9 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 0.7 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.7 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 0.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.3 7.9 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.6 4.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 3.2 GO:0042056 chemoattractant activity(GO:0042056)
0.0 2.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.3 2.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 2.2 GO:0005109 frizzled binding(GO:0005109)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.3 1.6 GO:0035240 dopamine binding(GO:0035240)
0.0 1.6 GO:0047485 protein N-terminus binding(GO:0047485)
0.3 1.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 1.5 GO:0005112 Notch binding(GO:0005112)
0.2 1.3 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.4 1.2 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.2 1.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 1.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 1.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 1.1 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0 1.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 3.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.2 ST_STAT3_PATHWAY STAT3 Pathway
0.1 2.0 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.2 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 2.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.0 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.9 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.8 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 0.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.7 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.7 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.5 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing