Motif ID: Crx_Gsc

Z-value: 0.434

Transcription factors associated with Crx_Gsc:

Gene SymbolEntrez IDGene Name
Crx ENSMUSG00000041578.9 Crx
Gsc ENSMUSG00000021095.4 Gsc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Crxmm10_v2_chr7_-_15879844_158799680.314.9e-02Click!


Activity profile for motif Crx_Gsc.

activity profile for motif Crx_Gsc


Sorted Z-values histogram for motif Crx_Gsc

Sorted Z-values for motif Crx_Gsc



Network of associatons between targets according to the STRING database.



First level regulatory network of Crx_Gsc

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_1010543 2.956 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr14_+_65968483 1.763 ENSMUST00000022616.6
 Clu
clusterin
chr4_+_74013442 1.120 ENSMUST00000098006.2
ENSMUST00000084474.5
 Frmd3

FERM domain containing 3

chr14_-_87141206 1.105 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr2_+_69722797 1.039 ENSMUST00000090858.3
 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr1_-_189688074 1.020 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr14_-_87141114 0.991 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr11_+_104231390 0.866 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr11_+_78322965 0.801 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr2_-_164404606 0.753 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
 Matn4


matrilin 4


chr1_+_85575676 0.728 ENSMUST00000178024.1
 G530012D18Rik
RIKEN cDNA G530012D1 gene
chr17_-_25570678 0.714 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr13_+_110395041 0.712 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr7_-_4532419 0.701 ENSMUST00000094897.4
 Dnaaf3
dynein, axonemal assembly factor 3
chr10_-_127341583 0.686 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr5_+_77265454 0.677 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chr12_-_69357120 0.633 ENSMUST00000021368.8
 Nemf
nuclear export mediator factor
chr12_+_118846329 0.579 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr11_-_102579071 0.551 ENSMUST00000107080.1
 Gm11627
predicted gene 11627
chr2_+_163225363 0.548 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0006413 translational initiation(GO:0006413)
0.3 1.8 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 1.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 1.0 GO:0021591 ventricular system development(GO:0021591)
0.1 0.9 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 0.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.8 GO:0048678 response to axon injury(GO:0048678)
0.2 0.7 GO:0072034 renal vesicle induction(GO:0072034)
0.2 0.7 GO:0060032 notochord regression(GO:0060032)
0.2 0.7 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 0.7 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.7 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 0.6 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.6 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.5 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.5 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.1 0.4 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.4 GO:0060242 contact inhibition(GO:0060242)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0005814 centriole(GO:0005814)
0.3 1.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.1 1.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.9 GO:0097418 neurofibrillary tangle(GO:0097418)
0.1 0.7 GO:0097542 ciliary tip(GO:0097542)
0.1 0.6 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0000799 nuclear condensin complex(GO:0000799) germinal vesicle(GO:0042585)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.7 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.5 GO:0070840 dynein complex binding(GO:0070840)
0.0 1.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.9 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 0.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.7 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.4 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 0.3 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0032051 clathrin light chain binding(GO:0032051)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.0 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.9 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.4 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events