Motif ID: Ddit3

Z-value: 0.719


Transcription factors associated with Ddit3:

Gene SymbolEntrez IDGene Name
Ddit3 ENSMUSG00000025408.9 Ddit3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ddit3mm10_v2_chr10_+_127290774_1272908030.517.5e-04Click!


Activity profile for motif Ddit3.

activity profile for motif Ddit3


Sorted Z-values histogram for motif Ddit3

Sorted Z-values for motif Ddit3



Network of associatons between targets according to the STRING database.



First level regulatory network of Ddit3

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_109823585 5.277 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chrX_+_103422010 5.045 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr10_+_112271123 4.473 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr19_-_59076069 3.293 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr15_-_43869993 3.105 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr9_-_121495678 2.914 ENSMUST00000035120.4
 Cck
cholecystokinin
chr5_-_114273702 2.741 ENSMUST00000144050.1
ENSMUST00000044790.5
 Foxn4

forkhead box N4

chr5_+_137288273 2.503 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr6_+_21215472 2.501 ENSMUST00000081542.5
 Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr3_-_127409014 2.477 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
 Ank2


ankyrin 2, brain


chr9_-_44799179 2.397 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr3_+_9403049 2.378 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
 C030034L19Rik


RIKEN cDNA C030034L19 gene


chr8_-_99416397 2.116 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
 Cdh8




cadherin 8




chr3_-_127408937 2.063 ENSMUST00000183095.1
ENSMUST00000182610.1
 Ank2

ankyrin 2, brain

chr8_+_12915879 2.063 ENSMUST00000110876.2
ENSMUST00000110879.2
 Mcf2l

mcf.2 transforming sequence-like

chr5_+_137553517 2.059 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr15_-_59082026 1.991 ENSMUST00000080371.6
 Mtss1
metastasis suppressor 1
chr3_-_49757257 1.970 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr18_+_37421418 1.854 ENSMUST00000053073.4
 Pcdhb11
protocadherin beta 11
chr19_-_4334001 1.775 ENSMUST00000176653.1
 Kdm2a
lysine (K)-specific demethylase 2A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.8 7.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.4 4.5 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.3 2.9 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.1 2.8 GO:0045475 locomotor rhythm(GO:0045475)
0.3 2.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.2 2.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 2.7 GO:0007416 synapse assembly(GO:0007416)
0.4 2.5 GO:0019695 choline metabolic process(GO:0019695)
0.1 2.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.7 2.0 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 1.8 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.0 1.8 GO:0006338 chromatin remodeling(GO:0006338)
0.1 1.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 1.7 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.1 1.6 GO:1990403 embryonic brain development(GO:1990403)
0.2 1.5 GO:0044838 cell quiescence(GO:0044838)
0.1 1.5 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 1.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 1.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 7.1 GO:0031430 M band(GO:0031430)
0.3 4.6 GO:0043083 synaptic cleft(GO:0043083)
0.2 2.9 GO:0043203 axon hillock(GO:0043203)
0.0 2.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.1 GO:0016514 SWI/SNF complex(GO:0016514)
0.2 1.7 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.6 GO:0035869 ciliary transition zone(GO:0035869)
0.1 1.5 GO:1990635 proximal dendrite(GO:1990635)
0.3 1.3 GO:0031673 H zone(GO:0031673)
0.0 1.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 1.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.1 1.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.0 GO:1990037 Lewy body core(GO:1990037)
0.0 1.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.9 GO:0016600 flotillin complex(GO:0016600)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.8 GO:0043196 varicosity(GO:0043196)
0.0 0.8 GO:0030914 STAGA complex(GO:0030914)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.8 GO:0030507 spectrin binding(GO:0030507)
0.0 8.3 GO:0005509 calcium ion binding(GO:0005509)
0.2 4.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.7 2.7 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.6 2.5 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.5 2.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 2.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 2.0 GO:0003785 actin monomer binding(GO:0003785)
0.3 1.8 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.5 1.5 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 1.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 1.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 1.2 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 1.2 GO:0070412 R-SMAD binding(GO:0070412)
0.4 1.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 2.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.2 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.8 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.7 PID_MYC_PATHWAY C-MYC pathway
0.0 0.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 2.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.4 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.0 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 0.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 0.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.4 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation