Motif ID: Dlx1
Z-value: 0.874
Transcription factors associated with Dlx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Dlx1 | ENSMUSG00000041911.3 | Dlx1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dlx1 | mm10_v2_chr2_+_71529085_71529110 | 0.37 | 1.8e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 137 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 8.5 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 1.0 | 4.1 | GO:0032788 | saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789) |
| 0.1 | 3.4 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.6 | 2.9 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 0.9 | 2.6 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
| 0.0 | 2.6 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
| 0.8 | 2.5 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 0.8 | 2.5 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 0.0 | 2.4 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.3 | 2.2 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.2 | 2.2 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.4 | 2.1 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.1 | 2.1 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.1 | 1.6 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 1.6 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.5 | 1.5 | GO:2000040 | regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.1 | 1.4 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.0 | 1.4 | GO:0006821 | chloride transport(GO:0006821) |
| 0.2 | 1.3 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.2 | 1.3 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 51 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.7 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 7.3 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 3.9 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 2.9 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.1 | 2.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.2 | 2.5 | GO:0042581 | specific granule(GO:0042581) |
| 0.1 | 2.2 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 1.3 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 1.2 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 1.2 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 1.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 1.0 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 1.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.0 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 0.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.2 | 0.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 0.6 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.0 | 0.6 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.6 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.6 | GO:0031672 | A band(GO:0031672) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 102 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 7.9 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.2 | 4.0 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.4 | 2.9 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.8 | 2.5 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.6 | 2.5 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 0.1 | 2.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 2.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.3 | 2.1 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.6 | 1.9 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.1 | 1.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 1.6 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.1 | 1.6 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.3 | 1.4 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 1.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 1.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.2 | 1.3 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 1.3 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 1.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.4 | 1.2 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.1 | 1.2 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
Gene overrepresentation in C2:CP category:
Showing 1 to 18 of 18 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 2.5 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.3 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.3 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.2 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.0 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.0 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.8 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.8 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.7 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.5 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 0.5 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.4 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.2 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 35 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 4.5 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.8 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 2.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 2.6 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 2.2 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.6 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 1.5 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 1.5 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.4 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.3 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.1 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 0.8 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 0.8 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.6 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.6 | REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.1 | 0.5 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_SIGNALING_BY_CBL | Genes involved in Regulation of signaling by CBL |
