Motif ID: Dlx5_Dlx4

Z-value: 1.204

Transcription factors associated with Dlx5_Dlx4:

Gene SymbolEntrez IDGene Name
Dlx4 ENSMUSG00000020871.7 Dlx4
Dlx5 ENSMUSG00000029755.9 Dlx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx5mm10_v2_chr6_-_6882068_6882092-0.561.4e-04Click!


Activity profile for motif Dlx5_Dlx4.

activity profile for motif Dlx5_Dlx4


Sorted Z-values histogram for motif Dlx5_Dlx4

Sorted Z-values for motif Dlx5_Dlx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx5_Dlx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 13.094 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr3_+_55782500 9.001 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr9_-_16378231 5.414 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr3_+_146121655 3.642 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr1_-_24612700 3.389 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr1_+_6487231 3.332 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr17_+_29090969 3.286 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr8_-_57653023 3.225 ENSMUST00000034021.5
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chrM_+_9870 3.216 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr12_-_55014329 3.084 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr9_-_66514567 2.915 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr16_+_52031549 2.817 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr2_+_165655237 2.633 ENSMUST00000063433.7
 Eya2
eyes absent 2 homolog (Drosophila)
chr2_-_26246707 2.622 ENSMUST00000166349.1
 C030048H21Rik
RIKEN cDNA C030048H21 gene
chr7_+_38183217 2.613 ENSMUST00000165308.1
 1600014C10Rik
RIKEN cDNA 1600014C10 gene
chr2_-_121235689 2.611 ENSMUST00000142400.1
 Trp53bp1
transformation related protein 53 binding protein 1
chrM_+_10167 2.549 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr6_-_50456085 2.445 ENSMUST00000146341.1
ENSMUST00000071728.4
 Osbpl3

oxysterol binding protein-like 3

chr3_-_19264959 2.413 ENSMUST00000121951.1
 Pde7a
phosphodiesterase 7A
chr8_+_45628176 2.159 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 13.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 6.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 5.9 GO:0010842 retina layer formation(GO:0010842)
0.1 4.5 GO:0008347 glial cell migration(GO:0008347)
0.1 4.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 3.9 GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400)
0.1 3.5 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.3 3.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 3.1 GO:0006338 chromatin remodeling(GO:0006338)
0.7 2.9 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.9 2.8 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 2.8 GO:0043010 camera-type eye development(GO:0043010)
0.2 2.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3 2.6 GO:0016576 histone dephosphorylation(GO:0016576)
0.2 2.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 2.6 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 2.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 2.5 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.1 2.1 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.3 2.0 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 4.4 GO:0005938 cell cortex(GO:0005938)
1.1 3.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 3.2 GO:0070469 respiratory chain(GO:0070469)
0.8 3.1 GO:0008623 CHRAC(GO:0008623)
0.0 3.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.5 2.9 GO:0044305 calyx of Held(GO:0044305)
0.1 2.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.0 GO:0000792 heterochromatin(GO:0000792)
0.1 1.9 GO:0060077 inhibitory synapse(GO:0060077)
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 1.7 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 1.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.7 GO:0005813 centrosome(GO:0005813)
0.3 1.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.4 GO:0031045 dense core granule(GO:0031045)
0.1 1.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.4 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 8.0 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.2 6.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 5.3 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
0.0 4.1 GO:0051015 actin filament binding(GO:0051015)
0.2 3.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 3.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
1.1 3.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 3.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 3.3 GO:0008017 microtubule binding(GO:0008017)
0.2 3.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
1.0 2.9 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 2.7 GO:0015485 cholesterol binding(GO:0015485)
0.4 2.6 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 2.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.5 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 2.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 2.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 2.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 1.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 3.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 3.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 2.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 1.0 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 3.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 3.4 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 3.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 3.2 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 3.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 1.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.9 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.8 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling