Motif ID: E2f1

Z-value: 6.258


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569720_1545697990.851.7e-12Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 119.845 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr15_-_98004634 76.478 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr15_-_98004695 75.465 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr14_-_79301623 70.682 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr13_-_23761223 47.498 ENSMUST00000102964.2
 Hist1h4a
histone cluster 1, H4a
chr1_-_20820213 44.288 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr14_-_103843685 41.044 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr10_-_78591945 40.085 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chrY_+_90784738 39.831 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1
chrX_+_170009892 39.223 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chrX_+_170009659 38.843 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chr19_+_36409719 35.334 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr10_-_120476469 34.878 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr17_+_56303396 33.623 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr2_+_70562007 32.646 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr2_+_71528657 31.815 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr4_-_137796350 30.803 ENSMUST00000030551.4
 Alpl
alkaline phosphatase, liver/bone/kidney
chr17_+_56303321 30.705 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr7_+_65862029 30.607 ENSMUST00000055576.5
ENSMUST00000098391.4
 Pcsk6

proprotein convertase subtilisin/kexin type 6

chr13_-_60177357 30.177 ENSMUST00000065086.4
 Gas1
growth arrest specific 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 468 entries
Log-likelihood per target Total log-likelihoodTermDescription
13.7 163.8 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
4.8 120.1 GO:0006270 DNA replication initiation(GO:0006270)
5.2 109.8 GO:0007530 sex determination(GO:0007530)
5.0 94.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
6.0 90.4 GO:0010216 maintenance of DNA methylation(GO:0010216)
11.7 81.8 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
17.0 68.0 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
3.5 63.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
5.9 58.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.2 57.9 GO:0035019 somatic stem cell population maintenance(GO:0035019)
19.2 57.5 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.1 52.7 GO:0051310 metaphase plate congression(GO:0051310)
2.3 47.4 GO:0040034 regulation of development, heterochronic(GO:0040034)
9.0 45.0 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
3.0 44.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.3 44.1 GO:0006260 DNA replication(GO:0006260)
14.6 43.7 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
14.5 43.4 GO:0014826 vein smooth muscle contraction(GO:0014826)
8.0 40.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
8.0 40.0 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 412.0 GO:0005634 nucleus(GO:0005634)
12.6 151.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
9.1 136.8 GO:0042555 MCM complex(GO:0042555)
0.3 120.1 GO:0000228 nuclear chromosome(GO:0000228)
2.0 116.8 GO:0005657 replication fork(GO:0005657)
3.1 100.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.5 76.2 GO:0000775 chromosome, centromeric region(GO:0000775)
1.8 69.5 GO:0060077 inhibitory synapse(GO:0060077)
0.7 67.9 GO:0005814 centriole(GO:0005814)
0.2 61.8 GO:0009986 cell surface(GO:0009986)
1.7 55.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
10.3 51.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
5.1 51.4 GO:0000796 condensin complex(GO:0000796)
1.9 40.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.8 40.1 GO:0031519 PcG protein complex(GO:0031519)
0.2 39.9 GO:0009897 external side of plasma membrane(GO:0009897)
13.2 39.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
1.9 38.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
6.3 37.7 GO:0098536 deuterosome(GO:0098536)
0.6 35.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 275 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 220.2 GO:0042393 histone binding(GO:0042393)
30.4 151.9 GO:0042289 MHC class II protein binding(GO:0042289)
3.2 119.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.9 100.2 GO:0003678 DNA helicase activity(GO:0003678)
2.9 96.4 GO:0070412 R-SMAD binding(GO:0070412)
0.5 83.3 GO:0001047 core promoter binding(GO:0001047)
11.3 79.4 GO:0004351 glutamate decarboxylase activity(GO:0004351)
18.6 74.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.7 66.5 GO:0004386 helicase activity(GO:0004386)
0.6 62.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
15.0 60.0 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
10.3 51.4 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.3 48.4 GO:0017025 TBP-class protein binding(GO:0017025)
2.9 46.6 GO:0003680 AT DNA binding(GO:0003680)
0.6 41.6 GO:0003697 single-stranded DNA binding(GO:0003697)
13.7 41.0 GO:0004962 endothelin receptor activity(GO:0004962)
3.7 40.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
4.2 37.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.4 32.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
5.2 31.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 202.8 PID_E2F_PATHWAY E2F transcription factor network
3.4 187.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
3.4 156.4 PID_ATR_PATHWAY ATR signaling pathway
2.2 99.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.7 63.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
4.1 57.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 55.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
1.9 46.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
1.4 41.7 PID_FANCONI_PATHWAY Fanconi anemia pathway
1.2 40.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.7 39.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.7 39.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.6 31.6 PID_CMYB_PATHWAY C-MYB transcription factor network
1.1 30.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.7 30.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
1.0 30.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.7 27.8 PID_FGF_PATHWAY FGF signaling pathway
0.7 27.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
1.4 27.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.2 27.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 188.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
3.0 143.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
8.0 128.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
5.6 101.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
3.8 86.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
3.6 81.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
4.6 78.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
5.6 72.7 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.6 52.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.6 46.1 REACTOME_MITOTIC_G2_G2_M_PHASES Genes involved in Mitotic G2-G2/M phases
4.8 43.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.3 36.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.6 34.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.4 33.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.6 33.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.5 32.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
1.3 31.1 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
3.1 28.0 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.7 26.9 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
1.8 25.6 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis