Motif ID: E2f2_E2f5

Z-value: 3.849

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.904.7e-16Click!
E2f5mm10_v2_chr3_+_14578609_145786870.871.4e-13Click!


Activity profile for motif E2f2_E2f5.

activity profile for motif E2f2_E2f5


Sorted Z-values histogram for motif E2f2_E2f5

Sorted Z-values for motif E2f2_E2f5



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 40.889 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr4_+_136172367 39.663 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr3_+_98013503 38.629 ENSMUST00000079812.6
 Notch2
notch 2
chr13_-_24761440 34.342 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr13_-_24761861 33.487 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr2_-_157204483 33.473 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr10_-_69352886 30.727 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr10_-_60219260 29.589 ENSMUST00000135158.2
 Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
chr8_+_75109528 29.210 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr17_+_56304313 29.035 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr1_-_20820213 28.811 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr12_+_24708241 27.408 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr9_+_122951051 26.007 ENSMUST00000040717.5
 Kif15
kinesin family member 15
chr10_+_110745433 25.973 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
 E2f7



E2F transcription factor 7



chr2_+_72476159 25.161 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr13_-_55329723 25.087 ENSMUST00000021941.7
 Mxd3
Max dimerization protein 3
chr2_+_72476225 22.583 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr2_+_119112793 21.720 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr12_-_69228167 20.856 ENSMUST00000021359.5
 Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr4_+_126556935 19.598 ENSMUST00000048391.8
 Clspn
claspin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 107.3 GO:0006270 DNA replication initiation(GO:0006270)
1.2 77.4 GO:0008156 negative regulation of DNA replication(GO:0008156)
8.0 56.3 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
4.0 55.5 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
16.8 50.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
5.4 48.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.7 45.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
5.1 40.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.5 40.3 GO:0006342 chromatin silencing(GO:0006342)
12.9 38.6 GO:0035622 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
3.9 38.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.8 31.9 GO:0043550 regulation of lipid kinase activity(GO:0043550)
3.5 31.7 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
5.7 28.7 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
3.1 27.9 GO:0090166 Golgi disassembly(GO:0090166)
6.8 27.3 GO:0006272 leading strand elongation(GO:0006272)
1.0 25.9 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
2.6 23.6 GO:0033504 floor plate development(GO:0033504)
3.3 23.0 GO:1902969 mitotic DNA replication(GO:1902969)
7.2 21.7 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 179.3 GO:0005634 nucleus(GO:0005634)
7.9 118.5 GO:0042555 MCM complex(GO:0042555)
1.6 88.0 GO:0005657 replication fork(GO:0005657)
0.3 77.9 GO:0005667 transcription factor complex(GO:0005667)
0.4 58.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.7 48.3 GO:0000786 nucleosome(GO:0000786)
9.0 45.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 32.7 GO:0043235 receptor complex(GO:0043235)
0.6 30.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
5.9 29.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
4.1 29.0 GO:0031298 replication fork protection complex(GO:0031298)
3.2 28.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.4 25.7 GO:0005871 kinesin complex(GO:0005871)
1.3 22.9 GO:0000800 lateral element(GO:0000800)
0.0 21.4 GO:0031012 extracellular matrix(GO:0031012)
0.2 21.2 GO:0005814 centriole(GO:0005814)
0.1 21.2 GO:0000139 Golgi membrane(GO:0000139)
0.3 18.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
2.0 18.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
3.5 17.7 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 101.9 GO:0001047 core promoter binding(GO:0001047)
0.1 90.5 GO:0003677 DNA binding(GO:0003677)
0.8 64.0 GO:0070491 repressing transcription factor binding(GO:0070491)
4.4 62.1 GO:0003688 DNA replication origin binding(GO:0003688)
12.3 49.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.9 48.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
9.0 45.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.3 44.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.8 39.7 GO:0003678 DNA helicase activity(GO:0003678)
1.0 38.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 37.5 GO:0004386 helicase activity(GO:0004386)
2.4 36.4 GO:0035173 histone kinase activity(GO:0035173)
5.6 33.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 31.0 GO:0042393 histone binding(GO:0042393)
7.4 29.6 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
2.9 28.7 GO:0008517 folic acid transporter activity(GO:0008517)
3.7 25.8 GO:0000150 recombinase activity(GO:0000150)
0.3 25.7 GO:0003777 microtubule motor activity(GO:0003777)
0.1 22.0 GO:0005096 GTPase activator activity(GO:0005096)
4.8 19.4 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 176.9 PID_E2F_PATHWAY E2F transcription factor network
2.8 124.3 PID_ATR_PATHWAY ATR signaling pathway
0.7 69.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
4.8 67.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
5.7 51.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 41.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.6 32.5 PID_PLK1_PATHWAY PLK1 signaling events
0.9 24.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.8 23.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
1.2 15.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.5 15.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 14.0 PID_FGF_PATHWAY FGF signaling pathway
0.3 13.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.3 13.1 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.3 10.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.4 8.8 PID_CD40_PATHWAY CD40/CD40L signaling
0.3 8.4 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 6.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.4 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 6.2 PID_ERBB4_PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.9 159.8 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
8.6 138.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
9.8 107.5 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
4.1 57.5 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.9 45.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
3.4 37.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
2.1 36.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
2.7 32.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 32.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.6 31.7 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
1.0 26.0 REACTOME_KINESINS Genes involved in Kinesins
2.4 21.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.6 17.5 REACTOME_G1_PHASE Genes involved in G1 Phase
1.3 14.0 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
2.8 11.4 REACTOME_LAGGING_STRAND_SYNTHESIS Genes involved in Lagging Strand Synthesis
0.1 11.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 10.5 REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.9 9.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.8 8.8 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 8.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation