Motif ID: E2f3
Z-value: 0.940
Transcription factors associated with E2f3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2f3 | ENSMUSG00000016477.11 | E2f3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f3 | mm10_v2_chr13_-_29984219_29984353 | 0.28 | 7.9e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 104 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.3 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.2 | 3.7 | GO:0043486 | histone exchange(GO:0043486) |
| 1.1 | 3.2 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 0.1 | 2.8 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.9 | 2.6 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.3 | 2.4 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.2 | 2.4 | GO:0006312 | mitotic recombination(GO:0006312) |
| 0.1 | 2.3 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.4 | 2.1 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.2 | 2.1 | GO:0033504 | floor plate development(GO:0033504) |
| 0.1 | 2.0 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.1 | 2.0 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.0 | 1.9 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.3 | 1.8 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.3 | 1.8 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 0.2 | 1.7 | GO:0051307 | meiotic chromosome separation(GO:0051307) |
| 0.1 | 1.6 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.0 | 1.5 | GO:0033120 | positive regulation of RNA splicing(GO:0033120) |
| 0.0 | 1.4 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 1.4 | GO:0097194 | execution phase of apoptosis(GO:0097194) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 56 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.5 | 3.5 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 2.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.4 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 2.1 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.2 | 2.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 2.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 2.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.4 | 2.0 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.1 | 2.0 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.6 | 1.8 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.2 | 1.8 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.1 | 1.4 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.3 | 1.3 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.0 | 1.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.2 | 1.2 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.0 | 1.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 1.1 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.1 | 1.1 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.2 | 1.0 | GO:0000938 | GARP complex(GO:0000938) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 75 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 7.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 3.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 2.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 2.8 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 2.7 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 2.7 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.4 | 2.6 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 2.1 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 2.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.4 | 2.0 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.0 | 2.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.5 | 1.8 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.3 | 1.8 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.3 | 1.8 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.1 | 1.8 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 1.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.3 | 1.3 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.2 | 1.3 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.4 | 1.2 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
Gene overrepresentation in C2:CP category:
Showing 1 to 17 of 17 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 5.3 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 3.5 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.9 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.9 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 1.6 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.2 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.2 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.2 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 0.9 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 0.7 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 0.7 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.4 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.3 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.2 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.1 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 35 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 3.9 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 3.4 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 3.3 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 3.2 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 2.9 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.6 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 2.1 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 1.5 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.3 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 1.2 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.1 | 1.2 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.2 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 1.2 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.1 | 1.1 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.1 | 1.1 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 1.0 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.9 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 0.8 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
