Motif ID: E2f6

Z-value: 1.160


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.612.6e-05Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 20.253 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr15_-_98004634 13.801 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr15_-_98004695 13.632 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr2_+_71529085 11.839 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr13_+_48261427 9.463 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr6_+_108660616 8.713 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr6_+_108660772 6.753 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr7_+_144838590 6.112 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr2_-_71546745 6.068 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr2_+_71528657 5.122 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr4_+_125490688 5.118 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr7_+_19094594 5.050 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr4_-_137796350 4.763 ENSMUST00000030551.4
 Alpl
alkaline phosphatase, liver/bone/kidney
chr2_+_71389239 4.583 ENSMUST00000028408.2
 Hat1
histone aminotransferase 1
chr7_-_38107490 4.579 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr19_-_45742873 4.565 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chrX_+_142681398 4.462 ENSMUST00000112889.1
ENSMUST00000101198.2
ENSMUST00000112891.1
ENSMUST00000087333.2
 Tmem164



transmembrane protein 164



chr6_+_42350000 4.436 ENSMUST00000164375.1
 Zyx
zyxin
chr2_+_164562579 4.406 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr6_+_6863769 4.337 ENSMUST00000031768.6
 Dlx6
distal-less homeobox 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 391 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 40.5 GO:0071599 otic vesicle development(GO:0071599)
1.1 24.3 GO:0060009 Sertoli cell development(GO:0060009)
7.7 23.0 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.6 17.4 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.4 16.1 GO:0006270 DNA replication initiation(GO:0006270)
1.3 10.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
2.4 9.8 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.6 9.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 8.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
1.9 7.5 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.3 6.6 GO:0046325 negative regulation of glucose import(GO:0046325)
0.1 6.5 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
2.1 6.4 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
1.6 6.3 GO:0003360 brainstem development(GO:0003360)
0.3 6.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.6 5.7 GO:0006348 chromatin silencing at telomere(GO:0006348)
1.8 5.4 GO:0030421 defecation(GO:0030421)
0.7 5.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 5.2 GO:0046677 response to antibiotic(GO:0046677)
1.0 5.1 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 28.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 17.0 GO:0005884 actin filament(GO:0005884)
0.1 15.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 10.5 GO:0001741 XY body(GO:0001741)
1.9 9.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 8.5 GO:0000791 euchromatin(GO:0000791)
0.5 8.1 GO:0042555 MCM complex(GO:0042555)
0.3 6.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 6.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.9 6.2 GO:0001740 Barr body(GO:0001740)
2.0 6.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 5.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 5.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 4.8 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.3 4.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 4.2 GO:0016363 nuclear matrix(GO:0016363)
0.2 4.1 GO:0071564 npBAF complex(GO:0071564)
0.0 4.0 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 3.8 GO:0005925 focal adhesion(GO:0005925)
0.3 3.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 231 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.5 27.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.6 21.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 17.8 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.6 15.5 GO:0043426 MRF binding(GO:0043426)
0.0 12.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.3 10.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
1.9 9.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 9.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 9.0 GO:0042393 histone binding(GO:0042393)
0.2 8.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 8.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 8.1 GO:0005178 integrin binding(GO:0005178)
1.0 7.1 GO:0034056 estrogen response element binding(GO:0034056)
1.3 6.7 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 6.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 6.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.0 6.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.7 5.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
1.0 5.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.9 5.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 30.6 NABA_COLLAGENS Genes encoding collagen proteins
0.3 23.1 PID_E2F_PATHWAY E2F transcription factor network
0.3 21.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.9 17.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 12.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 12.8 PID_ATR_PATHWAY ATR signaling pathway
0.2 11.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 10.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 10.1 PID_FGF_PATHWAY FGF signaling pathway
0.5 9.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.7 9.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 8.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 8.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 8.1 PID_ALK1_PATHWAY ALK1 signaling events
0.2 7.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 7.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 5.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 5.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.6 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 28.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 17.3 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.7 15.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.6 14.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
1.0 13.3 REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2
0.3 11.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 10.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.7 9.0 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.1 7.4 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.5 7.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 7.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 5.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 5.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 5.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 5.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 4.5 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3 4.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 4.0 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.2 3.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
3.7 3.7 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants